Molecular Basis of Gut Microbiome-Associated Colorectal Cancer: A&#160;Synthetic Perspective. (Q48286824)

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31 March 2020

title

Molecular Basis of Gut Microbiome-Associated Colorectal Cancer: A Synthetic Perspective (English)

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31 March 2020

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1

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31 March 2020

Seth B. Herzon

series ordinal

2

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31 March 2020

author name string

Alan R Healy

series ordinal

1

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http://europepmc.org/abstract/MED/28949546

10 February 2018

Seth B Herzon

series ordinal

2

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http://europepmc.org/abstract/MED/28949546

10 February 2018

language of work or name

English

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publication date

12 October 2017

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Journal of the American Chemical Society

31 March 2020

published in

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31 March 2020

volume

139

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31 March 2020

page(s)

14817-14824

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31 March 2020

issue

42

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Genotoxicity of Escherichia coli Nissle 1917 strain cannot be dissociated from its probiotic activity

31 March 2020

cites work

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12 December 2020

MACC1, a newly identified key regulator of HGF-MET signaling, predicts colon cancer metastasis

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12 December 2020

Bacterial genotoxin colibactin promotes colon tumour growth by inducing a senescence-associated secretory phenotype.

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12 December 2020

ClbP is a prototype of a peptidase subgroup involved in biosynthesis of nonribosomal peptides

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12 December 2020

Comparative metabolomics and structural characterizations illuminate colibactin pathway-dependent small molecules.

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12 December 2020

Divergent biosynthesis yields a cytotoxic aminomalonate-containing precolibactin

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12 December 2020

Methyl methanesulfonate (MMS) produces heat-labile DNA damage but no detectable in vivo DNA double-strand breaks

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12 December 2020

A prodrug resistance mechanism is involved in colibactin biosynthesis and cytotoxicity

1 reference

12 December 2020

Antimicrobials Inspired by Nonribosomal Peptide Synthetase Gene Clusters.

1 reference

12 December 2020

Interplay between siderophores and colibactin genotoxin in Escherichia coli

1 reference

12 December 2020

Analysis of structure-function relationships in the colibactin-maturating enzyme ClbP

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12 December 2020

Yatakemycin: total synthesis, DNA alkylation, and biological properties

1 reference

12 December 2020

Convergent and Modular Synthesis of Candidate Precolibactins. Structural Revision of Precolibactin A.

1 reference

12 December 2020

MATE transport of the E. coli-derived genotoxin colibactin.

1 reference

12 December 2020

The Enterobacterial Genotoxins: Cytolethal Distending Toxin and Colibactin

1 reference

12 December 2020

The colibactin warhead crosslinks DNA.

1 reference

12 December 2020

Colibactin: understanding an elusive gut bacterial genotoxin

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12 December 2020

Characterization of Polyketide Synthase Machinery from the pks Island Facilitates Isolation of a Candidate Precolibactin.

1 reference

12 December 2020

Escherichia coli induces DNA damage in vivo and triggers genomic instability in mammalian cells

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12 December 2020

In vivo evidence for a prodrug activation mechanism during colibactin maturation.

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12 December 2020

Prevalence of pks-positive Escherichia coli in Japanese patients with or without colorectal cancer

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12 December 2020

Isolation of a metabolite from the pks island provides insights into colibactin biosynthesis and activity.

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12 December 2020

DNA damage induced by alkylating agents and repair pathways

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12 December 2020

Outer Membrane Vesicles from the Probiotic Escherichia coli Nissle 1917 and the Commensal ECOR12 Enter Intestinal Epithelial Cells via Clathrin-Dependent Endocytosis and Elicit Differential Effects on DNA Damage

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12 December 2020

Locoregional Effects of Microbiota in a Preclinical Model of Colon Carcinogenesis.

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12 December 2020

Role and mechanisms of action of Escherichia coli Nissle 1917 in the maintenance of remission in ulcerative colitis patients: An update

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12 December 2020

Two more pieces of the colibactin genotoxin puzzle from Escherichia coli show incorporation of an unusual 1-aminocyclopropanecarboxylic acid moiety

1 reference

12 December 2020

High prevalence of mucosa-associated E. coli producing cyclomodulin and genotoxin in colon cancer

1 reference

12 December 2020

The Microbes inside Us and the Race for Colibactin

1 reference

12 December 2020

Natural products version 2.0: connecting genes to molecules.

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12 December 2020

Discovery of MRSA active antibiotics using primary sequence from the human microbiome.

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12 December 2020

Mechanism and regulation of incisions during DNA interstrand cross-link repair

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12 December 2020

Small-molecule inhibitors prevent the genotoxic and protumoural effects induced by colibactin-producing bacteria.

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12 December 2020

A Mechanistic Model for Colibactin-Induced Genotoxicity.

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12 December 2020

Microbial metabolites in health and disease: Navigating the unknown in search of function

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12 December 2020

Colibactin biosynthesis and biological activity depend on the rare aminomalonyl polyketide precursor

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12 December 2020

Critical Intermediates Reveal New Biosynthetic Events in the Enigmatic Colibactin Pathway

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12 December 2020

Domain-Targeted Metabolomics Delineates the Heterocycle Assembly Steps of Colibactin Biosynthesis.

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12 December 2020

Intestinal inflammation targets cancer-inducing activity of the microbiota.

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12 December 2020

Escherichia coli induces DNA double-strand breaks in eukaryotic cells.

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12 December 2020

Colonization of the human gut by E. coli and colorectal cancer risk

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12 December 2020

Linking Biosynthetic Gene Clusters to their Metabolites via Pathway- Targeted Molecular Networking

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12 December 2020

Activation of the DNA damage checkpoint and genomic instability in human precancerous lesions

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12 December 2020

Identifiers

DOI

10.1021/JACS.7B07807

1 reference

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31 March 2020

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31 March 2020

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