Colibactin: understanding an elusive gut bacterial genotoxin (Q34495096)

2 August 2017

Colibactin: understanding an elusive gut bacterial genotoxin (English)

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2 August 2017

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Emily P Balskus

1

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2 August 2017

22 September 2015

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2 August 2017

Natural Product Reports

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2 August 2017

32

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2 August 2017

11

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2 August 2017

1534-1540

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Specialized metabolites from the microbiome in health and disease

2 August 2017

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https://api.crossref.org/works/10.1039%2FC5NP00091B

HUMAN MICROBIOTA. Small molecules from the human microbiota

21 January 2018

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https://api.crossref.org/works/10.1039%2FC5NP00091B

A systematic analysis of biosynthetic gene clusters in the human microbiome reveals a common family of antibiotics.

21 January 2018

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https://api.crossref.org/works/10.1039%2FC5NP00091B

Human and plant fungal pathogens: the role of secondary metabolites

21 January 2018

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https://api.crossref.org/works/10.1039%2FC5NP00091B

The chemical arsenal of Burkholderia pseudomallei is essential for pathogenicity.

21 January 2018

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https://api.crossref.org/works/10.1039%2FC5NP00091B

Escherichia coli induces DNA double-strand breaks in eukaryotic cells.

21 January 2018

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https://api.crossref.org/works/10.1039%2FC5NP00091B

Molecular epidemiology and phylogenetic distribution of the Escherichia coli pks genomic island

21 January 2018

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https://api.crossref.org/works/10.1039%2FC5NP00091B

Genetic structure and distribution of the colibactin genomic island among members of the family Enterobacteriaceae.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC5NP00091B

Intestinal inflammation targets cancer-inducing activity of the microbiota.

21 January 2018

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https://api.crossref.org/works/10.1039%2FC5NP00091B

Escherichia coli induces DNA damage in vivo and triggers genomic instability in mammalian cells

21 January 2018

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https://api.crossref.org/works/10.1039%2FC5NP00091B

Escherichia coli producing colibactin triggers premature and transmissible senescence in mammalian cells

21 January 2018

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https://api.crossref.org/works/10.1039%2FC5NP00091B

Bacterial genotoxin colibactin promotes colon tumour growth by inducing a senescence-associated secretory phenotype.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC5NP00091B

High prevalence of mucosa-associated E. coli producing cyclomodulin and genotoxin in colon cancer

21 January 2018

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https://api.crossref.org/works/10.1039%2FC5NP00091B

Screening metatranscriptomes for toxin genes as functional drivers of human colorectal cancer.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC5NP00091B

Oral tolerance failure upon neonatal gut colonization with Escherichia coli producing the genotoxin colibactin

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC5NP00091B

Maternally acquired genotoxic Escherichia coli alters offspring's intestinal homeostasis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC5NP00091B

The genotoxin colibactin exacerbates lymphopenia and decreases survival rate in mice infected with septicemic Escherichia coli.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC5NP00091B

The Genotoxin Colibactin Is a Determinant of Virulence in Escherichia coli K1 Experimental Neonatal Systemic Infection

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC5NP00091B

Genotoxicity of Escherichia coli Nissle 1917 strain cannot be dissociated from its probiotic activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC5NP00091B

The genus Pseudovibrio contains metabolically versatile bacteria adapted for symbiosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC5NP00091B

Gut symbionts from distinct hosts exhibit genotoxic activity via divergent colibactin biosynthesis pathways.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC5NP00091B

Expression analysis of the colibactin gene cluster coding for a novel polyketide in Escherichia coli.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC5NP00091B

Characterization of the complete zwittermicin A biosynthesis gene cluster from Bacillus cereus

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC5NP00091B

A new type of pyrrolidine biosynthesis is involved in the late steps of xenocoumacin production in Xenorhabdus nematophila.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC5NP00091B

A natural prodrug activation mechanism in nonribosomal peptide synthesis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC5NP00091B

A prodrug resistance mechanism is involved in colibactin biosynthesis and cytotoxicity

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC5NP00091B

ClbP is a prototype of a peptidase subgroup involved in biosynthesis of nonribosomal peptides

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC5NP00091B

Analysis of structure-function relationships in the colibactin-maturating enzyme ClbP

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC5NP00091B

In vivo evidence for a prodrug activation mechanism during colibactin maturation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC5NP00091B

Comparative metabolomics and structural characterizations illuminate colibactin pathway-dependent small molecules.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC5NP00091B

Isolation of a metabolite from the pks island provides insights into colibactin biosynthesis and activity.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC5NP00091B

Two more pieces of the colibactin genotoxin puzzle from Escherichia coli show incorporation of an unusual 1-aminocyclopropanecarboxylic acid moiety

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC5NP00091B

The colibactin warhead crosslinks DNA.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC5NP00091B

Critical Intermediates Reveal New Biosynthetic Events in the Enigmatic Colibactin Pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC5NP00091B

Chemical and biological explorations of the family of CC-1065 and the duocarmycin natural products.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC5NP00091B

Chemistry and biology of acylfulvenes: sesquiterpene-derived antitumor agents.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC5NP00091B

Bleomycin: new perspectives on the mechanism of action

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC5NP00091B

A natural prodrug activation mechanism in the biosynthesis of nonribosomal peptides.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC5NP00091B

Interplay between siderophores and colibactin genotoxin biosynthetic pathways in Escherichia coli

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC5NP00091B

Small-molecule inhibitors prevent the genotoxic and protumoural effects induced by colibactin-producing bacteria.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC5NP00091B

Insights into secondary metabolism from a global analysis of prokaryotic biosynthetic gene clusters

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC5NP00091B

Microbiology: Microbiome science needs a healthy dose of scepticism

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC5NP00091B

21 January 2018

Identifiers

DOI

10.1039/C5NP00091B

1 reference

release_exhj6vszqzecbiujlji7apji6i

2 August 2017

1 reference

Fatcat

https://api.fatcat.wiki/v0/release/exhj6vszqzecbiujlji7apji6i

mapped directly with Wikidata item

24 November 2022

based on heuristic

PubMed ID

26390983

1 reference

PubMed ID

26390983