Domain-Targeted Metabolomics Delineates the Heterocycle Assembly Steps of Colibactin Biosynthesis. (Q48190463)

http://europepmc.org/abstract/PMC/5831107

4 July 2018

title

Domain-Targeted Metabolomics Delineates the Heterocycle Assembly Steps of Colibactin Biosynthesis. (English)

1 reference

http://europepmc.org/abstract/PMC/5831107

4 July 2018

0 references

0 references

0 references

1

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28240912%20AND%20SRC:MED&resulttype=core&format=json

13 June 2020

Alan R Healy

2

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28240912%20AND%20SRC:MED&resulttype=core&format=json

13 June 2020

Seth B. Herzon

4

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28240912%20AND%20SRC:MED&resulttype=core&format=json

13 June 2020

Jason M Crawford

5

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28240912%20AND%20SRC:MED&resulttype=core&format=json

13 June 2020

author name string

Emilee E Shine

3

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28240912%20AND%20SRC:MED&resulttype=core&format=json

13 June 2020

language of work or name

English

0 references

publication date

10 March 2017

1 reference

http://europepmc.org/abstract/PMC/5831107

4 July 2018

number of pages

7

1 reference

based on heuristic

inferred from page(s)

published in

Journal of the American Chemical Society

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28240912%20AND%20SRC:MED&resulttype=core&format=json

13 June 2020

volume

139

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28240912%20AND%20SRC:MED&resulttype=core&format=json

13 June 2020

page(s)

4195-4201

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28240912%20AND%20SRC:MED&resulttype=core&format=json

13 June 2020

issue

11

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28240912%20AND%20SRC:MED&resulttype=core&format=json

Two more pieces of the colibactin genotoxin puzzle from Escherichia coli show incorporation of an unusual 1-aminocyclopropanecarboxylic acid moiety

13 June 2020

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Divergent biosynthesis yields a cytotoxic aminomalonate-containing precolibactin

10 July 2018

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The Enterobacterial Genotoxins: Cytolethal Distending Toxin and Colibactin

10 July 2018

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Convergent and Modular Synthesis of Candidate Precolibactins. Structural Revision of Precolibactin A.

10 July 2018

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10 July 2018

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10 July 2018

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10 July 2018

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10 July 2018

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10 July 2018

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Critical Intermediates Reveal New Biosynthetic Events in the Enigmatic Colibactin Pathway

10 July 2018

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Lumiquinone A, an α-Aminomalonate-Derived Aminobenzoquinone from Photorhabdus luminescens

10 July 2018

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The colibactin warhead crosslinks DNA.

10 July 2018

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Gut symbionts from distinct hosts exhibit genotoxic activity via divergent colibactin biosynthesis pathways.

10 July 2018

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The bacterial genotoxin colibactin promotes colon tumor growth by modifying the tumor microenvironment

10 July 2018

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10 July 2018

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Comparative metabolomics and structural characterizations illuminate colibactin pathway-dependent small molecules.

10 July 2018

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Assembly line polyketide synthases: mechanistic insights and unsolved problems

10 July 2018

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Nonproteinogenic amino acid building blocks for nonribosomal peptide and hybrid polyketide scaffolds

10 July 2018

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Analysis of structure-function relationships in the colibactin-maturating enzyme ClbP

10 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5831107

Intestinal inflammation targets cancer-inducing activity of the microbiota.

10 July 2018

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Genotoxicity of Escherichia coli Nissle 1917 strain cannot be dissociated from its probiotic activity

10 July 2018

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ClbP is a prototype of a peptidase subgroup involved in biosynthesis of nonribosomal peptides

10 July 2018

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Comparative analysis of the biosynthetic gene clusters and pathways for three structurally related antitumor antibiotics: bleomycin, tallysomycin, and zorbamycin

10 July 2018

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5831107

Escherichia coli induces DNA damage in vivo and triggers genomic instability in mammalian cells

10 July 2018

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5831107

Programming cells by multiplex genome engineering and accelerated evolution

10 July 2018

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5831107

Starter unit specificity directs genome mining of polyketide synthase pathways in fungi

10 July 2018

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Identification of a starter unit acyl-carrier protein transacylase domain in an iterative type I polyketide synthase

10 July 2018

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Escherichia coli induces DNA double-strand breaks in eukaryotic cells.

10 July 2018

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10 July 2018

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Ethylene biosynthesis: Identification of 1-aminocyclopropane-1-carboxylic acid as an intermediate in the conversion of methionine to ethylene

10 July 2018

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10 July 2018

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10 July 2018

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10 July 2018

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A Mechanistic Model for Colibactin-Induced Genotoxicity.

10 July 2018

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Characterization of Polyketide Synthase Machinery from the pks Island Facilitates Isolation of a Candidate Precolibactin.

14 August 2018

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5831107

Isolation of a metabolite from the pks island provides insights into colibactin biosynthesis and activity.

14 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5831107

In vivo evidence for a prodrug activation mechanism during colibactin maturation.

14 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5831107

A prodrug resistance mechanism is involved in colibactin biosynthesis and cytotoxicity

14 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5831107

Colibactin biosynthesis and biological activity depend on the rare aminomalonyl polyketide precursor

14 August 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/28240912

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1021/JACS.7B00659

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28240912%20AND%20SRC:MED&resulttype=core&format=json

13 June 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28240912%20AND%20SRC:MED&resulttype=core&format=json

13 June 2020

1 reference