Sulforaphane Ameliorates 3-Nitropropionic Acid-Induced Striatal Toxicity by Activating the Keap1-Nrf2-ARE Pathway and Inhibiting the MAPKs and NF-κB Pathways. (Q48117214)

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English	Sulforaphane Ameliorates 3-Nitropropionic Acid-Induced Striatal Toxicity by Activating the Keap1-Nrf2-ARE Pathway and Inhibiting the MAPKs and NF-κB Pathways.	scientific article

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scholarly article

1 reference

Europe PubMed Central

8 February 2018

http://europepmc.org/abstract/MED/26096705

Sulforaphane Ameliorates 3-Nitropropionic Acid-Induced Striatal Toxicity by Activating the Keap1-Nrf2-ARE Pathway and Inhibiting the MAPKs and NF-κB Pathways. (English)

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Europe PubMed Central

8 February 2018

http://europepmc.org/abstract/MED/26096705

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author name string

Minhee Jang

1

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Europe PubMed Central

8 February 2018

http://europepmc.org/abstract/MED/26096705

Ik-Hyun Cho

2

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Europe PubMed Central

8 February 2018

http://europepmc.org/abstract/MED/26096705

publication date

23 June 2015

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Europe PubMed Central

8 February 2018

http://europepmc.org/abstract/MED/26096705

Molecular Neurobiology

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Europe PubMed Central

8 February 2018

http://europepmc.org/abstract/MED/26096705

53

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Europe PubMed Central

8 February 2018

http://europepmc.org/abstract/MED/26096705

4

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Europe PubMed Central

8 February 2018

http://europepmc.org/abstract/MED/26096705

2619-2635

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Europe PubMed Central

8 February 2018

http://europepmc.org/abstract/MED/26096705

https://scigraph.springernature.com/pub.10.1007/s12035-015-9230-2

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Mitochondria in Huntington's disease

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The role of oxidative stress in Huntington's disease: are antioxidants good therapeutic candidates?

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Biochemical abnormalities and excitotoxicity in Huntington's disease brain.

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Increased oxidative damage and mitochondrial abnormalities in the peripheral blood of Huntington's disease patients

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Dopamine determines the vulnerability of striatal neurons to the N-terminal fragment of mutant huntingtin through the regulation of mitochondrial complex II.

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Chronic microglial activation and progressive dopaminergic neurotoxicity.

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Subacute systemic 3-nitropropionic acid intoxication induces a distinct motor disorder in adult C57Bl/6 mice: behavioural and histopathological characterisation

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3-Nitropropionic acid as a tool to study the mechanisms involved in Huntington's disease: past, present and future.

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Pretreatment with Bacopa monnieri extract offsets 3-nitropropionic acid induced mitochondrial oxidative stress and dysfunctions in the striatum of prepubertal mouse brain

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Toward clinical application of the Keap1-Nrf2 pathway

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The Keap1-Nrf2 cell defense pathway--a promising therapeutic target?

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The Nrf2-ARE pathway: a valuable therapeutic target for the treatment of neurodegenerative diseases

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Sulforaphane: translational research from laboratory bench to clinic

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Molecular basis for chemoprevention by sulforaphane: a comprehensive review.

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Sulforaphane as a potential protective phytochemical against neurodegenerative diseases

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Neuroprotective effects of sulforaphane after contusive spinal cord injury.

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Efficacy of fumaric acid esters in the R6/2 and YAC128 models of Huntington's disease

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Fumaric acid esters exert neuroprotective effects in neuroinflammation via activation of the Nrf2 antioxidant pathway.

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In vitro and in vivo characterization of a tunable dual-reactivity probe of the Nrf2-ARE pathway

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Role of microglial IKKbeta in kainic acid-induced hippocampal neuronal cell death

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Microglial Toll-like receptor 2 contributes to kainic acid-induced glial activation and hippocampal neuronal cell death.

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Analysis of Relative Gene Expression Data Using Real-Time Quantitative PCR and the 2−ΔΔCT Method

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The 3-NP Model of Striatal Neurodegeneration

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Mice overexpressing 70-kDa heat shock protein show increased resistance to malonate and 3-nitropropionic acid

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Glial cells as intrinsic components of non-cell-autonomous neurodegenerative disease

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Small molecule activators of the Nrf2-HO-1 antioxidant axis modulate heme metabolism and inflammation in BV2 microglia cells

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The transcription factor Nrf2 is a therapeutic target against brain inflammation

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NADPH oxidase 2-derived reactive oxygen species in spinal cord microglia contribute to peripheral nerve injury-induced neuropathic pain

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Sulforaphane suppresses LPS-induced inflammation in primary rat microglia

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tBHQ inhibits LPS-induced microglial activation via Nrf2-mediated suppression of p38 phosphorylation

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Nrf2 and NF-κB modulation by sulforaphane counteracts multiple manifestations of diabetic neuropathy in rats and high glucose-induced changes

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Possible role of sertraline against 3-nitropropionic acid induced behavioral, oxidative stress and mitochondrial dysfunctions in rat brain

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Substance P exacerbates dopaminergic neurodegeneration through neurokinin-1 receptor-independent activation of microglial NADPH oxidase

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Inducible nitric oxide synthase is key to peroxynitrite-mediated, LPS-induced protein radical formation in murine microglial BV2 cells.

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Microglial activation correlates with severity in Huntington disease: a clinical and PET study.

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Do glial cells play an anti-oxidative role in Huntington's disease?

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Mutant huntingtin activates Nrf2-responsive genes and impairs dopamine synthesis in a PC12 model of Huntington's disease

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Triterpenoids CDDO-ethyl amide and CDDO-trifluoroethyl amide improve the behavioral phenotype and brain pathology in a transgenic mouse model of Huntington's disease

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MAPKs: new targets for neurodegeneration

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Activation of mitogen-activated protein kinases in gerbil hippocampus with ischemic tolerance induced by 3-nitropropionic acid.

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Activation of MLK2-mediated signaling cascades by polyglutamine-expanded huntingtin

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Age-associated changes in SAPK/JNK and p38 MAPK signaling in response to the generation of ROS by 3-nitropropionic acid

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Fas activation of the p38 mitogen-activated protein kinase signalling pathway requires ICE/CED-3 family proteases

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Deranged neuronal calcium signaling and Huntington disease.

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Role of NF-kappaB and MAPKs in light-induced photoreceptor apoptosis

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Activation of the IkappaB kinase complex and nuclear factor-kappaB contributes to mutant huntingtin neurotoxicity.

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Role of LOX/COX pathways in 3-nitropropionic acid-induced Huntington's disease-like symptoms in rats: protective effect of licofelone

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Partial inhibition of brain succinate dehydrogenase by 3-nitropropionic acid is sufficient to initiate striatal degeneration in rat.

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12 December 2020

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Korean Red Ginseng Extract Attenuates 3-Nitropropionic Acid-Induced Huntington's-Like Symptoms

1 reference

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12 December 2020

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Minocycline and sulforaphane inhibited lipopolysaccharide-mediated retinal microglial activation.

1 reference

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1 reference

https://pubmed.ncbi.nlm.nih.gov/26096705

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

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10.1007/S12035-015-9230-2

1 reference

Europe PubMed Central

8 February 2018

http://europepmc.org/abstract/MED/26096705

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Europe PubMed Central

8 February 2018

http://europepmc.org/abstract/MED/26096705

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