MAPKs: new targets for neurodegeneration (Q35095136)

6 August 2017

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title

MAPKs: new targets for neurodegeneration (English)

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6 August 2017

Sarah J Harper

1

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6 August 2017

Neil Wilkie

series ordinal

2

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6 August 2017

language of work or name

English

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publication date

1 April 2003

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Expert Opinion on Therapeutic Targets

6 August 2017

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6 August 2017

7

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6 August 2017

187-200

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6 August 2017

2

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Apoptosis. Baiting death inhibitors.

6 August 2017

1 reference

https://api.crossref.org/works/10.1517%2F14728222.7.2.187

IAP proteins: blocking the road to death's door

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.7.2.187

Opposing effects of ERK and JNK-p38 MAP kinases on apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.7.2.187

Mammalian MAP kinase signalling cascades

21 January 2018

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https://api.crossref.org/works/10.1517%2F14728222.7.2.187

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.7.2.187

Mitogen-activated protein kinase pathways

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.7.2.187

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.7.2.187

Neuroprotection by MAPK/ERK kinase inhibition with U0126 against oxidative stress in a mouse neuronal cell line and rat primary cultured cortical neurons

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.7.2.187

Zn2+-induced ERK activation mediated by reactive oxygen species causes cell death in differentiated PC12 cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.7.2.187

PD 098059 is a specific inhibitor of the activation of mitogen-activated protein kinase kinase in vitro and in vivo

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.7.2.187

Differential expression of active, phosphorylation-dependent MAP kinases, MAPK/ERK, SAPK/JNK and p38, and specific transcription factor substrates following quinolinic acid excitotoxicity in the rat.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.7.2.187

MEK1 protein kinase inhibition protects against damage resulting from focal cerebral ischemia

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.7.2.187

Active, phosphorylation-dependent mitogen-activated protein kinase (MAPK/ERK), stress-activated protein kinase/c-Jun N-terminal kinase (SAPK/JNK), and p38 kinase expression in Parkinson's disease and Dementia with Lewy bodies.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.7.2.187

Inhibition of the p44/42 MAP kinase pathway protects hippocampal neurons in a cell-culture model of seizure activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.7.2.187

A MAP kinase targeted by endotoxin and hyperosmolarity in mammalian cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.7.2.187

A protein kinase involved in the regulation of inflammatory cytokine biosynthesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.7.2.187

The primary structure of p38 gamma: a new member of p38 group of MAP kinases

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.7.2.187

Molecular cloning and characterization of a novel p38 mitogen-activated protein kinase

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.7.2.187

The p38 signal transduction pathway: activation and function

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.7.2.187

Bidirectional regulation of p38 kinase and c-Jun N-terminal protein kinase by insulin-like growth factor-I.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.7.2.187

Signalling for survival and death in neurones: the role of stress-activated kinases, JNK and p38

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.7.2.187

JNK and p38 stresskinases--degenerative effectors of signal-transduction-cascades in the nervous system

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.7.2.187

Activity and expression of JNK1, p38 and ERK kinases, c-Jun N-terminal phosphorylation, and c-jun promoter binding in the adult rat brain following kainate-induced seizures

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.7.2.187

Immunolocalization of p38 MAP kinase in mouse brain.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.7.2.187

p38 kinase is activated in the Alzheimer's disease brain.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.7.2.187

The selective p38 inhibitor SB-239063 protects primary neurons from mild to moderate excitotoxic injury

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.7.2.187

SB 239063, a novel p38 inhibitor, attenuates early neuronal injury following ischemia.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.7.2.187

Minocycline blocks nitric oxide-induced neurotoxicity by inhibition p38 MAP kinase in rat cerebellar granule neurons

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.7.2.187

Minocycline prevents nigrostriatal dopaminergic neurodegeneration in the MPTP model of Parkinson's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.7.2.187

Minocycline delays disease onset and mortality in a transgenic model of ALS.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.7.2.187

Minocycline inhibits cytochrome c release and delays progression of amyotrophic lateral sclerosis in mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.7.2.187

Epidermal immunization by a needle-free powder delivery technology: Immunogenicity of influenza vaccine and protection in mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.7.2.187

Tetracyclines inhibit microglial activation and are neuroprotective in global brain ischemia

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.7.2.187

p493F12 kinase: a novel MAP kinase expressed in a subset of neurons in the human nervous system

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.7.2.187

Collaboration of JNKs and ERKs in nerve growth factor regulation of the neurofilament light chain promoter in PC12 cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.7.2.187

JNK3 contributes to c-Jun activation and apoptosis but not oxidative stress in nerve growth factor-deprived sympathetic neurons

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.7.2.187

Absence of excitotoxicity-induced apoptosis in the hippocampus of mice lacking the Jnk3 gene

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.7.2.187

beta-Amyloid-induced neuronal apoptosis requires c-Jun N-terminal kinase activation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.7.2.187

CEP-1347/KT-7515, an inhibitor of SAPK/JNK pathway activation, promotes survival and blocks multiple events associated with Abeta-induced cortical neuron apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.7.2.187

Abeta 17-42 in Alzheimer's disease activates JNK and caspase-8 leading to neuronal apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.7.2.187

A cytoplasmic inhibitor of the JNK signal transduction pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.7.2.187

Jun NH2-terminal kinase (JNK) interacting protein 1 (JIP1) binds the cytoplasmic domain of the Alzheimer's beta-amyloid precursor protein (APP).

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.7.2.187

The gamma secretase-generated carboxyl-terminal domain of the amyloid precursor protein induces apoptosis via Tip60 in H4 cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.7.2.187

Activation and redistribution of c-jun N-terminal kinase/stress activated protein kinase in degenerating neurons in Alzheimer's disease.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.7.2.187

The parkinsonian neurotoxin, MPP+ induces phosphorylated c-Jun in dopaminergric neurons of mesencephalic cultures

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.7.2.187

Dopaminergic cell death induced by MPP(+), oxidant and specific neurotoxicants shares the common molecular mechanism

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.7.2.187

Gene transfer of the JNK interacting protein-1 protects dopaminergic neurons in the MPTP model of Parkinson's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.7.2.187

c-Jun mediates axotomy-induced dopamine neuron death in vivo

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.7.2.187

Expression of polyglutamine-expanded Huntingtin activates the SEK1-JNK pathway and induces apoptosis in a hippocampal neuronal cell line

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.7.2.187

p53 induction by tumor necrosis factor-alpha and involvement of p53 in cell death of human oligodendrocytes.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.7.2.187

Activation of C-jun N-terminal kinase/stress-activated protein kinase in primary glial cultures

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.7.2.187

AMPA receptor-mediated toxicity in oligodendrocyte progenitors involves free radical generation and activation of JNK, calpain and caspase 3.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.7.2.187

Extracellular signal-regulated kinase and c-Jun N-terminal protein kinase in ischemic tolerance.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.7.2.187

c-Jun N-terminal kinase activation in hippocampal CA1 region was involved in ischemic injury

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.7.2.187

Differential effects of ischemia and reperfusion on c-Jun N-terminal kinase isoform protein and activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.7.2.187

Protein kinases--the major drug targets of the twenty-first century?

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.7.2.187

Inhibition of JNK activation through NF-kappaB target genes

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.7.2.187

21 January 2018

Identifiers

DOI

10.1517/14728222.7.2.187

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release_ioqxt2q5mfg5da6h76l7df3jlq

6 August 2017

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Fatcat

https://api.fatcat.wiki/v0/release/ioqxt2q5mfg5da6h76l7df3jlq

mapped directly with Wikidata item

24 November 2022

based on heuristic

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