Exploiting differential RNA splicing patterns: a potential new group of therapeutic targets in cancer. (Q47784889)

5 February 2018

review article

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title

Exploiting differential RNA splicing patterns: a potential new group of therapeutic targets in cancer. (English)

1 reference

5 February 2018

author name string

Nidhi Jyotsana

series ordinal

1

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5 February 2018

Michael Heuser

series ordinal

2

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5 February 2018

language of work or name

English

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publication date

13 December 2017

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5 February 2018

Expert Opinion on Therapeutic Targets

published in

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5 February 2018

volume

22

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5 February 2018

page(s)

107-121

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5 February 2018

issue

2

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5 February 2018

Deep surveying of alternative splicing complexity in the human transcriptome by high-throughput sequencing

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Alternative splicing of BRAF transcripts and characterization of C-terminally truncated B-Raf isoforms in colorectal cancer

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Alternative splicings on p53, BRCA1 and PTEN genes involved in breast cancer

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HnRNP proteins controlled by c-Myc deregulate pyruvate kinase mRNA splicing in cancer

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The pathogenicity of splicing defects: mechanistic insights into pre-mRNA processing inform novel therapeutic approaches

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RBM5, 6, and 10 differentially regulate NUMB alternative splicing to control cancer cell proliferation

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SF3B1 association with chromatin determines splicing outcomes

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Mutations of the SF3B1 splicing factor in chronic lymphocytic leukemia: association with progression and fludarabine-refractoriness

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SRSF2 Is Essential for Hematopoiesis, and Its Myelodysplastic Syndrome-Related Mutations Dysregulate Alternative Pre-mRNA Splicing

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Disease-associated mutation in SRSF2 misregulates splicing by altering RNA-binding affinities

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The t(1;9)(p34;q34) fusing ABL1 with SFPQ, a pre-mRNA processing gene, is recurrent in acute lymphoblastic leukemias.

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Role of PSF-TFE3 oncoprotein in the development of papillary renal cell carcinomas

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Splicing factor SRP20 is a novel partner of BCL6 in a t(3;6)(q27;p21) translocation in transformed follicular lymphoma.

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The splicing factor SRSF6 is amplified and is an oncoprotein in lung and colon cancers

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Differential expression of the early lung cancer detection marker, heterogeneous nuclear ribonucleoprotein-A2/B1 (hnRNP-A2/B1) in normal breast and neoplastic breast cancer.

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The gene encoding the splicing factor SF2/ASF is a proto-oncogene

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Cell motility is controlled by SF2/ASF through alternative splicing of the Ron protooncogene

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Pharmacology of Modulators of Alternative Splicing

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The Akt-SRPK-SR axis constitutes a major pathway in transducing EGF signaling to regulate alternative splicing in the nucleus

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CD44 Isoform Status Predicts Response to Treatment with Anti-CD44 Antibody in Cancer Patients

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Gemcitabine triggers a pro-survival response in pancreatic cancer cells through activation of the MNK2/eIF4E pathway.

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Convergence of Acquired Mutations and Alternative Splicing of CD19 Enables Resistance to CART-19 Immunotherapy

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BCLAF1 and its splicing regulator SRSF10 regulate the tumorigenic potential of colon cancer cells

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M2 isoform of pyruvate kinase is dispensable for tumor maintenance and growth

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Lineage-specific splicing of a brain-enriched alternative exon promotes glioblastoma progression

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Cell type-restricted activity of hnRNPM promotes breast cancer metastasis via regulating alternative splicing

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Phosphorylation switches the general splicing repressor SRp38 to a sequence-specific activator.

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Protein kinase A phosphorylation modulates transport of the polypyrimidine tract-binding protein

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Differential effects of hyperphosphorylation on splicing factor SRp55

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Exon identity crisis: disease-causing mutations that disrupt the splicing code

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RNA splicing. The human splicing code reveals new insights into the genetic determinants of disease

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Aberrant and alternative splicing in cancer

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Inhibition of Mutated, Activated BRAF in Metastatic Melanoma

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The UPF1 RNA surveillance gene is commonly mutated in pancreatic adenosquamous carcinoma

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Inactivating mutations of the histone methyltransferase gene EZH2 in myeloid disorders

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Changes of telomerase activity by alternative splicing of full-length and beta variants of hTERT in breast cancer patients.

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Changes of the alternative splicing variants of human telomerase reverse transcriptase during gastric carcinogenesis.

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Patterns of missplicing caused by RB1 gene mutations in patients with retinoblastoma and association with phenotypic expression

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Coupling mRNA processing with transcription in time and space.

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The human SWI/SNF subunit Brm is a regulator of alternative splicing

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Hallmarks of alternative splicing in cancer

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Induction of endogenous Bcl-xS through the control of Bcl-x pre-mRNA splicing by antisense oligonucleotides

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Manipulation of PK-M mutually exclusive alternative splicing by antisense oligonucleotides

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Modulation of PKM alternative splicing by PTBP1 promotes gemcitabine resistance in pancreatic cancer cells.

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Exon skipping and dystrophin restoration in patients with Duchenne muscular dystrophy after systemic phosphorodiamidate morpholino oligomer treatment: an open-label, phase 2, dose-escalation study

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Exon-specific RNAi: a tool for dissecting the functional relevance of alternative splicing

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Systemically delivered antisense oligomers upregulate gene expression in mouse tissues

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Directing HER4 mRNA expression towards the CYT2 isoform by antisense oligonucleotide decreases growth of breast cancer cells in vitro and in vivo

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Antisense oligonucleotide-mediated MDM4 exon 6 skipping impairs tumor growth

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Spliceostatin A targets SF3b and inhibits both splicing and nuclear retention of pre-mRNA.

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Bifunctional antisense oligonucleotides provide a trans-acting splicing enhancer that stimulates SMN2 gene expression in patient fibroblasts

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Bifunctional RNAs targeting the intronic splicing silencer N1 increase SMN levels and reduce disease severity in an animal model of spinal muscular atrophy

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Correction of disease-associated exon skipping by synthetic exon-specific activators

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Synthetic oligonucleotides recruit ILF2/3 to RNA transcripts to modulate splicing

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Selective modification of alternative splicing by indole derivatives that target serine-arginine-rich protein splicing factors

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The development and application of small molecule modulators of SF3b as therapeutic agents for cancer.

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Sudemycins, novel small molecule analogues of FR901464, induce alternative gene splicing

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RNA Splicing Modulation Selectively Impairs Leukemia Stem Cell Maintenance in Secondary Human AML

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Biological validation that SF3b is a target of the antitumor macrolide pladienolide

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Reduced fidelity of branch point recognition and alternative splicing induced by the anti-tumor drug spliceostatin A

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The anti-tumor drug E7107 reveals an essential role for SF3b in remodeling U2 snRNP to expose the branch point-binding region

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Modulation of splicing catalysis for therapeutic targeting of leukemia with mutations in genes encoding spliceosomal proteins

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Manipulation of alternative splicing by a newly developed inhibitor of Clks

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Topical antiangiogenic SRPK1 inhibitors reduce choroidal neovascularization in rodent models of exudative AMD

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Serine-arginine protein kinase 1 (SRPK1) inhibition as a potential novel targeted therapeutic strategy in prostate cancer

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Utilization of host SR protein kinases and RNA-splicing machinery during viral replication

21 January 2018

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Spliceosome-mediated trans-splicing: the therapeutic cut and paste

21 January 2018

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Phenotype correction of hemophilia A mice by spliceosome-mediated RNA trans-splicing

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Ribozyme-mediated repair of sickle beta-globin mRNAs in erythrocyte precursors

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Induction of wild-type p53 activity in human cancer cells by ribozymes that repair mutant p53 transcripts

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In vivo reprogramming of hTERT by trans-splicing ribozyme to target tumor cells

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Splice variants as cancer biomarkers

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Splice isoforms as therapeutic targets for colorectal cancer

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Inhibition of vemurafenib-resistant melanoma by interference with pre-mRNA splicing

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The spliceosome is a therapeutic vulnerability in MYC-driven cancer

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Oncogenic splicing factor SRSF1 is a critical transcriptional target of MYC.

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MYC regulates the core pre-mRNA splicing machinery as an essential step in lymphomagenesis

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Morpholino-mediated increase in soluble Flt-1 expression results in decreased ocular and tumor neovascularization

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F14728222.2018.1417390

Antitumorigenic potential of STAT3 alternative splicing modulation

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F14728222.2018.1417390

Modification of HER2 pre-mRNA alternative splicing and its effects on breast cancer cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F14728222.2018.1417390

RNA interference efficiently targets human leukemia driven by a fusion oncogene in vivo.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F14728222.2018.1417390

The MKK(3/6)-p38-signaling cascade alters the subcellular distribution of hnRNP A1 and modulates alternative splicing regulation

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F14728222.2018.1417390

Signal-dependent regulation of splicing via phosphorylation of Sam68

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F14728222.2018.1417390

Evaluation of PacBio sequencing for full-length bacterial 16S rRNA gene classification

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F14728222.2018.1417390

Miniaturized Nanopore DNA Sequencing: Accelerating the Path to Precision Medicine.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F14728222.2018.1417390

Distinct splicing signatures affect converged pathways in myelodysplastic syndrome patients carrying mutations in different splicing regulators

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F14728222.2018.1417390

Distinct splice variants and pathway enrichment in the cell-line models of aggressive human breast cancer subtypes

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F14728222.2018.1417390

A new class of protein cancer biomarker candidates: differentially expressed splice variants of ERBB2 (HER2/neu) and ERBB1 (EGFR) in breast cancer cell lines

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F14728222.2018.1417390

CDKN2A germline splicing mutation affecting both p16ink4 and p14arf RNA processing in a melanoma/neurofibroma kindred

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F14728222.2018.1417390

The Extra-domain A of Fibronectin Is a Vascular Marker of Solid Tumors and Metastases

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F14728222.2018.1417390

The EWS gene, involved in Ewing family of tumors, malignant melanoma of soft parts and desmoplastic small round cell tumors, codes for an RNA binding protein with novel regulatory domains

21 January 2018

1 reference

12 December 2020

The Clk/Sty protein kinase phosphorylates SR splicing factors and regulates their intranuclear distribution

1 reference

12 December 2020

The EWS-WT1 translocation product induces PDGFA in desmoplastic small round-cell tumour

1 reference

12 December 2020

RNA polymerase II targets pre-mRNA splicing factors to transcription sites in vivo

1 reference

12 December 2020

Heterogeneous nuclear ribonucleoprotein A2/B1 up-regulation in bronchial lavage specimens: a clinical marker of early lung cancer detection

1 reference

12 December 2020

Phase I therapy study with (186)Re-labeled humanized monoclonal antibody BIWA 4 (bivatuzumab) in patients with head and neck squamous cell carcinoma.

1 reference

12 December 2020

Making antisense of splicing.

1 reference

12 December 2020

Concerted regulation of nuclear and cytoplasmic activities of SR proteins by AKT

1 reference

12 December 2020

Efficient and persistent splice switching by systemically delivered LNA oligonucleotides in mice

1 reference

12 December 2020

RNA therapeutics: beyond RNA interference and antisense oligonucleotides

1 reference

12 December 2020

CD44v6 expression is related to mesenchymal phenotype and poor prognosis in patients with colorectal cancer

1 reference

12 December 2020

Uncovering the role of p53 splice variants in human malignancy: a clinical perspective

1 reference

12 December 2020

Mutations in the Spliceosomal Machinery Genes SRSF2, U2AF1, and ZRSR2 and Response to Decitabine in Myelodysplastic Syndrome.

1 reference

12 December 2020

Clonal hematopoiesis of indeterminate potential

1 reference

12 December 2020

10.1080/14728222.2018.1417390

Identifiers

DOI

1 reference

5 February 2018

release_ghrd62w5evdu7lbdhfpxonkr7e

Fatcat ID

1 reference

Fatcat

https://api.fatcat.wiki/v0/release/ghrd62w5evdu7lbdhfpxonkr7e

24 November 2022

mapped directly with Wikidata item

PubMed ID

29235382

1 reference

5 February 2018