Gemcitabine triggers a pro-survival response in pancreatic cancer cells through activation of the MNK2/eIF4E pathway. (Q39314466)

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7 February 2020

title

Gemcitabine triggers a pro-survival response in pancreatic cancer cells through activation of the MNK2/eIF4E pathway (English)

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7 February 2020

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3

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7 February 2020

Gabriele Capurso

4

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7 February 2020

Raffaele Geremia

6

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7 February 2020

Claudio Sette

8

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7 February 2020

author name string

L Adesso

1

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7 February 2020

S Calabretta

2

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E Pilozzi

5

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G Delle Fave

7

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language of work or name

English

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publication date

16 July 2012

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7 February 2020

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7 February 2020

volume

32

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7 February 2020

page(s)

2848-2857

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7 February 2020

issue

23

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https://scigraph.springernature.com/pub.10.1038/onc.2012.306

7 February 2020

exact match

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cites work

The complexity of pancreatic ductal cancers and multidimensional strategies for therapeutic targeting

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Targeting phosphoinositide 3-kinase pathways in pancreatic cancer--from molecular signalling to clinical trials.

21 January 2018

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Activation of Akt and eIF4E survival pathways by rapamycin-mediated mammalian target of rapamycin inhibition.

21 January 2018

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Inhibition of mammalian target of rapamycin induces phosphatidylinositol 3-kinase-dependent and Mnk-mediated eukaryotic translation initiation factor 4E phosphorylation

21 January 2018

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mTOR: from growth signal integration to cancer, diabetes and ageing

21 January 2018

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eIF4E promotes nuclear export of cyclin D1 mRNAs via an element in the 3'UTR

21 January 2018

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eIF4E--from translation to transformation

21 January 2018

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Mnk2 and Mnk1 are essential for constitutive and inducible phosphorylation of eukaryotic initiation factor 4E but not for cell growth or development

21 January 2018

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The Mnks: MAP kinase-interacting kinases (MAP kinase signal-integrating kinases).

21 January 2018

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Phosphorylation of eIF-4E positively regulates formation of the eIF-4F translation initiation complex following DNA damage

21 January 2018

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Phosphorylation of eIF4E by MNKs supports protein synthesis, cell cycle progression and proliferation in prostate cancer cells

21 January 2018

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Negative regulatory effects of Mnk kinases in the generation of chemotherapy-induced antileukemic responses

21 January 2018

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Dissecting eIF4E action in tumorigenesis

21 January 2018

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eIF4E phosphorylation promotes tumorigenesis and is associated with prostate cancer progression

21 January 2018

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Combined deficiency for MAP kinase-interacting kinase 1 and 2 (Mnk1 and Mnk2) delays tumor development

21 January 2018

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eIF4E activation is commonly elevated in advanced human prostate cancers and significantly related to reduced patient survival.

21 January 2018

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Overexpression of phospho-eIF4E is associated with survival through AKT pathway in non-small cell lung cancer.

21 January 2018

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Loss of MNK function sensitizes fibroblasts to serum-withdrawal induced apoptosis

21 January 2018

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The N and C termini of the splice variants of the human mitogen-activated protein kinase-interacting kinase Mnk2 determine activity and localization

21 January 2018

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The gene encoding the splicing factor SF2/ASF is a proto-oncogene

21 January 2018

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HnRNP proteins controlled by c-Myc deregulate pyruvate kinase mRNA splicing in cancer

21 January 2018

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The RNA-binding protein Sam68 is a multifunctional player in human cancer

21 January 2018

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Molecular targeting of the oncogene eIF4E in acute myeloid leukemia (AML): a proof-of-principle clinical trial with ribavirin.

21 January 2018

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Oral mTOR inhibitor everolimus in patients with gemcitabine-refractory metastatic pancreatic cancer

21 January 2018

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A missense mutation in the APC tumor suppressor gene disrupts an ASF/SF2 splicing enhancer motif and causes pathogenic skipping of exon 14.

21 January 2018

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A high proportion of DNA variants of BRCA1 and BRCA2 is associated with aberrant splicing in breast/ovarian cancer patients.

21 January 2018

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Targeting the RNA splicing machinery as a novel treatment strategy for pancreatic carcinoma

21 January 2018

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The RNA-binding protein Sam68 contributes to proliferation and survival of human prostate cancer cells

21 January 2018

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The splicing regulator Sam68 binds to a novel exonic splicing silencer and functions in SMN2 alternative splicing in spinal muscular atrophy

21 January 2018

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Identification and molecular characterization of Mnk1b, a splice variant of human MAP kinase-interacting kinase Mnk1

21 January 2018

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Therapeutic inhibition of MAP kinase interacting kinase blocks eukaryotic initiation factor 4E phosphorylation and suppresses outgrowth of experimental lung metastases

21 January 2018

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Serine-arginine protein kinase 1 overexpression is associated with tumorigenic imbalance in mitogen-activated protein kinase pathways in breast, colonic, and pancreatic carcinomas

31 March 2020

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31 March 2020

Identifiers

DOI

10.1038/ONC.2012.306

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22797067%20AND%20SRC:MED&resulttype=core&format=json

7 February 2020

1 reference