The EndoC-βH1 cell line is a valid model of human beta cells and applicable for screenings to identify novel drug target candidates. (Q47196030)

7 July 2018

title

The EndoC-βH1 cell line is a valid model of human beta cells and applicable for screenings to identify novel drug target candidates. (English)

1 reference

7 July 2018

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Christine Bruun

10

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Anna Kirstine Ringgaard

Anna Kirstine Ringgaard

5

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Maja Borup Kjær Petersen

Maja Borup Kjær Petersen

28

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Anne Grapin-Botton

Anne Grapin-Botton

29

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Allan Christian Shaw

17

Allan Christian Shaw

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7 July 2018

author name string

Violeta Georgieva Tsonkova

1

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Fredrik Wolfhagen Sand

2

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Xenia Asbæk Wolf

3

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Lars Groth Grunnet

4

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Camilla Ingvorsen

6

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Louise Winkel

7

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Mark Kalisz

8

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Kevin Dalgaard

9

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Johannes Josef Fels

11

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Charlotte Helgstrand

12

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Sven Hastrup

13

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Fredrik Kryh Öberg

14

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Erik Vernet

15

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Michael Paolo Bastner Sandrini

16

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Carsten Jessen

18

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Mads Grønborg

19

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Jacob Hald

20

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Hanni Willenbrock

21

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Dennis Madsen

22

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Rasmus Wernersson

23

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Lena Hansson

24

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Jan Nygaard Jensen

25

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Annette Plesner

26

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Tomas Alanentalo

27

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Christian Honoré

30

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Jonas Ahnfelt-Rønne

31

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Jacob Hecksher-Sørensen

32

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Philippe Ravassard

33

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Ole D Madsen

34

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Claude Rescan

35

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Thomas Frogne

36

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publication date

19 December 2017

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7 July 2018

published in

Molecular Metabolism

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7 July 2018

volume

8

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7 July 2018

page(s)

144-157

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7 July 2018

describes a project that uses

EndoC-betaH1

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cites work

Human beta cell mass and function in diabetes: Recent advances in knowledge and technologies to understand disease pathogenesis

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Single-Cell Gene Expression Analysis of a Human ESC Model of Pancreatic Endocrine Development Reveals Different Paths to β-Cell Differentiation

10 July 2018

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Expression and functional assessment of candidate type 2 diabetes susceptibility genes identify four new genes contributing to human insulin secretion

10 July 2018

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Aggregation of Engineered Human β-Cells Into Pseudoislets: Insulin Secretion and Gene Expression Profile in Normoxic and Hypoxic Milieu

10 July 2018

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A scored human protein-protein interaction network to catalyze genomic interpretation.

10 July 2018

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A Single-Cell Transcriptome Atlas of the Human Pancreas

10 July 2018

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Mass production of functional human pancreatic β-cells: why and how?

10 July 2018

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Single-Cell Transcriptomics of the Human Endocrine Pancreas.

10 July 2018

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Xenotropic retrovirus Bxv1 in human pancreatic β cell lines.

10 July 2018

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SerpinB1 Promotes Pancreatic β Cell Proliferation

10 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5985049

Inhibition of DYRK1A and GSK3B induces human β-cell proliferation.

10 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5985049

Physiological characterization of the human EndoC-βH1 β-cell line

10 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5985049

Calcium signaling in a genetically engineered human pancreatic β-cell line

10 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5985049

Characterization of stimulus-secretion coupling in the human pancreatic EndoC-βH1 beta cell line.

10 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5985049

A recombinant slow-release PACAP-derived peptide alleviates diabetes by promoting both insulin secretion and actions

10 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5985049

Human islet preparations distributed for research exhibit a variety of insulin-secretory profiles.

10 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5985049

STC1 expression is associated with tumor growth and metastasis in breast cancer.

10 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5985049

Integrative genomic analysis identifies that SERPINA6-rs1998056 regulated by FOXA/ERα is associated with female hepatocellular carcinoma

10 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5985049

The transcriptional landscape of mouse beta cells compared to human beta cells reveals notable species differences in long non-coding RNA and protein-coding gene expression.

10 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5985049

Effects of palmitate on genome-wide mRNA expression and DNA methylation patterns in human pancreatic islets

10 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5985049

ADCY5 couples glucose to insulin secretion in human islets

10 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5985049

In vitro formation of β cell pseudoislets using islet-derived endothelial cells

10 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5985049

Anti-caspase-3 preconditioning increases proinsulin secretion and deteriorates posttransplant function of isolated human islets

10 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5985049

Thioredoxin-interacting protein mediates ER stress-induced β cell death through initiation of the inflammasome

10 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5985049

β-cell-specific gene repression: a mechanism to protect against inappropriate or maladjusted insulin secretion?

10 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5985049

Islet-enriched gene expression and glucose-induced insulin secretion in human and mouse islets

10 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5985049

A genetically engineered human pancreatic β cell line exhibiting glucose-inducible insulin secretion

10 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5985049

Endoplasmic reticulum stress and pancreatic β-cell death

10 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5985049

Tissue-specific disallowance of housekeeping genes: the other face of cell differentiation.

10 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5985049

Trophic effects of PACAP on pancreatic islets: a mini-review.

10 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5985049

Glucolipotoxicity of the pancreatic beta cell.

10 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5985049

Glycogen synthase kinase-3 and mammalian target of rapamycin pathways contribute to DNA synthesis, cell cycle progression, and proliferation in human islets

10 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5985049

Initiation and execution of lipotoxic ER stress in pancreatic beta-cells

10 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5985049

Inhibition of GSK3 promotes replication and survival of pancreatic beta cells

10 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5985049

Glucose-induced [Ca2+]i abnormalities in human pancreatic islets: important role of overstimulation

10 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5985049

Glucagon-like peptide-1-(7-36)amide is transformed to glucagon-like peptide-1-(9-36)amide by dipeptidyl peptidase IV in the capillaries supplying the L cells of the porcine intestine.

10 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5985049

Beta-cell deterioration determines the onset and rate of progression of secondary dietary failure in type 2 diabetes mellitus: the 10-year follow-up of the Belfast Diet Study.

10 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5985049

Effect of Bombesin on Plasma Insulin, Pancreatic Glucagon, and Gut Glucagon in Man*

10 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5985049

In vivo action of bombesin on exocrine pancreatic secretion in the rat: independent of cholecystokinin and cholinergic mediation

10 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5985049

Prolonged exposure of human pancreatic islets to high glucose concentrations in vitro impairs the beta-cell function

10 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5985049

Bombesin Stimulates the Release of Insulin and Glucagon, but Not Pancreatic Somatostatin, from the Isolated Perfused Dog Pancreas

10 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5985049

Bombesin inhibits insulin release from isolated pancreatic islets of rats in vitro

10 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5985049

EndoC-βH1 cells display increased sensitivity to sodium palmitate when cultured in DMEM/F12 medium.

10 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5985049

Initial hyperinsulinemia and subsequent β-cell dysfunction is associated with elevated palmitate levels.

14 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5985049

IL-17A increases the expression of proinflammatory chemokines in human pancreatic islets

14 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5985049

SERPINA6, BEX1, AGTR1, SLC26A3, and LAPTM4B are markers of resistance to neoadjuvant chemotherapy in HER2-negative breast cancer.

14 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5985049

Over-expression of pancreatic pituitary adenylate cyclase-activating polypeptide (PACAP) aggravates cerulein-induced acute pancreatitis in mice

14 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5985049

Characterization of endocrine progenitor cells and critical factors for their differentiation in human adult pancreatic cell culture

14 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5985049

Insulin secretory function is impaired in isolated human islets carrying the Gly(972)-->Arg IRS-1 polymorphism

14 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5985049

Bombesin-induced residual stimulation of amylase release from mouse pancreatic acini

14 August 2018

1 reference

12 December 2020

Gastrin releasing peptide (GRP): effects on basal and stimulated insulin and glucagon secretion in the mouse

1 reference

12 December 2020

Pituitary adenylate cyclase-activating polypeptide stimulates insulin and glucagon secretion in humans

1 reference

12 December 2020

Intraperitoneal PACAP administration decreases blood glucose in GK rats, and in normal and high fat diet mice

1 reference

12 December 2020

Glycemic control in diabetes is restored by therapeutic manipulation of cytokines that regulate beta cell stress

1 reference

12 December 2020

10.1016/J.MOLMET.2017.12.007

Identifiers

DOI

1 reference

7 July 2018

PMCID

5985049

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7 July 2018

PubMed ID

29307512

1 reference

7 July 2018