A genetically engineered human pancreatic β cell line exhibiting glucose-inducible insulin secretion (Q38271856)

1 September 2017

A genetically engineered human pancreatic β cell line exhibiting glucose-inducible insulin secretion (English)

1 reference

1 September 2017

0 references

0 references

0 references

1 reference

Philippe Ravassard

1

0 references

author name string

Yasmine Hazhouz

2

1 reference

1 September 2017

Séverine Pechberty

3

1 reference

1 September 2017

Emilie Bricout-Neveu

4

1 reference

1 September 2017

Mathieu Armanet

5

1 reference

1 September 2017

Paul Czernichow

6

1 reference

1 September 2017

Raphael Scharfmann

7

1 reference

1 September 2017

language of work or name

English

0 references

publication date

25 August 2011

1 reference

Journal of Clinical Investigation

1 September 2017

1 reference

1 September 2017

121

1 reference

1 September 2017

3589-3597

1 reference

1 September 2017

9

1 reference

describes a project that uses

1 September 2017

EndoC-betaH1

0 references

cites work

Induction of human beta-cell proliferation and engraftment using a single G1/S regulatory molecule, cdk6

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3163974

Context-dependent transformation of adult pancreatic cells by oncogenic K-Ras

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3163974

A new strategy to generate functional insulin-producing cell lines by somatic gene transfer into pancreatic progenitors

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3163974

Beta cells within single human islets originate from multiple progenitors

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3163974

Histone deacetylase inhibitors modify pancreatic cell fate determination and amplify endocrine progenitors

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3163974

In Vitro Proliferation of Cells Derived From Adult Human -Cells Revealed By Cell-Lineage Tracing

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3163974

Islet amyloid in type 2 diabetes, and the toxic oligomer hypothesis

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3163974

Pancreatic endoderm derived from human embryonic stem cells generates glucose-responsive insulin-secreting cells in vivo

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3163974

Cell lines derived from pancreatic islets

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3163974

Regulation of insulin gene transcription

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3163974

Beta-cell differentiation from a human pancreatic cell line in vitro and in vivo

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3163974

Glucagon receptors on human islet cells contribute to glucose competence of insulin release

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3163974

Multiply attenuated lentiviral vector achieves efficient gene delivery in vivo

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3163974

Major species differences between humans and rodents in the susceptibility to pancreatic beta-cell injury

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3163974

Human and rat beta cells differ in glucose transporter but not in glucokinase gene expression

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3163974

Pancreatic islet GLUT2 glucose transporter mRNA and protein expression in humans with and without NIDDM.

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3163974

Insulin synthesis in a clonal cell line of simian virus 40-transformed hamster pancreatic beta cells

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3163974

Continuous, clonal, insulin- and somatostatin-secreting cell lines established from a transplantable rat islet cell tumor

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3163974

Cloning and functional expression in bacteria of a novel glucose transporter present in liver, intestine, kidney, and beta-pancreatic islet cells

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3163974

Beta-cell lines derived from transgenic mice expressing a hybrid insulin gene-oncogene

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3163974

Gene transfer by retrovirus vectors occurs only in cells that are actively replicating at the time of infection

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3163974

Establishment of 2-mercaptoethanol-dependent differentiated insulin-secreting cell lines

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3163974

A human beta-cell line for transplantation therapy to control type 1 diabetes.

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3163974

Prolonged exposure of human beta cells to elevated glucose levels results in sustained cellular activation leading to a loss of glucose regulation

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3163974

c-Myc controls proliferation versus differentiation in human pancreatic endocrine cells

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3163974

PDX-1 and cell-cell contact act in synergy to promote delta-cell development in a human pancreatic endocrine precursor cell line

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3163974

Isolation and characterization of a cell line from the epithelial cells of the human fetal pancreas

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3163974

Is GLUT2 required for glucose sensing?

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3163974

Development of a cell line from the human fetal pancreas.

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3163974

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3163974

Sustained proliferation of PDX-1+ cells derived from human islets

23 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3163974

Automated method for isolation of human pancreatic islets

23 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3163974

Establishment of a pancreatic beta cell line that retains glucose-inducible insulin secretion: special reference to expression of glucose transporter isoforms

23 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3163974

Proliferation of sorted human and rat beta cells

23 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3163974

Ex vivo analysis of acinar and endocrine cell development in the human embryonic pancreas.

31 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3163974

Efficient restricted gene expression in beta cells by lentivirus-mediated gene transfer into pancreatic stem/progenitor cells.

31 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3163974

Formation of amyloid in human pancreatic islets transplanted to the liver and spleen of nude mice.

31 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3163974

Blood glucose normalization upon transplantation of human embryonic pancreas into beta-cell-deficient SCID mice.

31 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3163974

Early pattern of differentiation in the human pancreas

31 August 2018

1 reference

12 December 2020

Identification and purification of functional human beta-cells by a new specific zinc-fluorescent probe

1 reference

12 December 2020

Predominance of stimulatory effects of interleukin-1 beta on isolated human pancreatic islets

1 reference

12 December 2020

Assessment of intracellular insulin content during all steps of human islet isolation procedure

1 reference

12 December 2020

The mesenchyme controls the timing of pancreatic beta-cell differentiation

1 reference

12 December 2020

Control of beta-cell differentiation by the pancreatic mesenchyme

1 reference

12 December 2020

Widespread amyloid deposition in transplanted human pancreatic islets

1 reference

12 December 2020

Identifiers

DOI

10.1172/JCI58447

1 reference

1 September 2017

1 reference

1 September 2017

1 reference