Mass production of functional human pancreatic β-cells: why and how? (Q38951189)

7 September 2017

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title

Mass production of functional human pancreatic β-cells: why and how? (English)

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7 September 2017

1

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27615142%20AND%20SRC:MED&resulttype=core&format=json

31 May 2020

author name string

M Didiesheim

2

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27615142%20AND%20SRC:MED&resulttype=core&format=json

31 May 2020

P Richards

3

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31 May 2020

V Chandra

4

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27615142%20AND%20SRC:MED&resulttype=core&format=json

31 May 2020

M Oshima

5

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31 May 2020

O Albagli

6

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31 May 2020

publication date

1 September 2016

1 reference

Diabetes, Obesity and Metabolism

7 September 2017

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27615142%20AND%20SRC:MED&resulttype=core&format=json

31 May 2020

volume

18 Suppl 1

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27615142%20AND%20SRC:MED&resulttype=core&format=json

31 May 2020

page(s)

128-136

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Glucose-sensing mechanisms in pancreatic beta-cells.

31 May 2020

cites work

1 reference

The stunned beta cell: a brief history

21 January 2018

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Pancreatic β-cell imaging in humans: fiction or option?

21 January 2018

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Pancreatic duct cells in human islet cell preparations are a source of angiogenic cytokines interleukin-8 and vascular endothelial growth factor

21 January 2018

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Concise review: in search of unlimited sources of functional human pancreatic beta cells

21 January 2018

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Paracrine and autocrine interactions in the human islet: more than meets the eye

21 January 2018

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Probe-independent and direct quantification of insulin mRNA and growth hormone mRNA in enriched cell preparations.

21 January 2018

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Islet-enriched gene expression and glucose-induced insulin secretion in human and mouse islets

21 January 2018

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Human and rat beta cells differ in glucose transporter but not in glucokinase gene expression

21 January 2018

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Voltage-gated ion channels in human pancreatic beta-cells: electrophysiological characterization and role in insulin secretion.

21 January 2018

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Major species differences between humans and rodents in the susceptibility to pancreatic beta-cell injury

21 January 2018

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Cytokines induce endoplasmic reticulum stress in human, rat and mouse beta cells via different mechanisms

21 January 2018

1 reference

Assessment of human pancreatic islet architecture and composition by laser scanning confocal microscopy

21 January 2018

1 reference

Human Islets Have Fewer Blood Vessels than Mouse Islets and the Density of Islet Vascular Structures Is Increased in Type 2 Diabetes

21 January 2018

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Innervation patterns of autonomic axons in the human endocrine pancreas

21 January 2018

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Insulin resistance alters islet morphology in nondiabetic humans

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Islet amyloid and type 2 diabetes: overproduction or inadequate clearance and detoxification?

21 January 2018

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Summary of the Keystone islet workshop (April 2014): the increasing demand for human islet availability in diabetes research

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Human islet preparations distributed for research exhibit a variety of insulin-secretory profiles.

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Transcriptomes of the major human pancreatic cell types.

21 January 2018

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Autofluorescence-activated cell sorting of pancreatic islet cells: Purification of insulin-containing B-cells according to glucose-induced changes in cellular redox state

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How to make a functional β-cell

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Differentiation of human pluripotent stem cells into β-cells: Potential and challenges

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Production of pancreatic hormone-expressing endocrine cells from human embryonic stem cells

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Pancreatic endoderm derived from human embryonic stem cells generates glucose-responsive insulin-secreting cells in vivo

21 January 2018

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Composition and function of macroencapsulated human embryonic stem cell-derived implants: comparison with clinical human islet cell grafts

21 January 2018

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Generation of functional human pancreatic β cells in vitro

21 January 2018

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Reversal of diabetes with insulin-producing cells derived in vitro from human pluripotent stem cells

21 January 2018

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Controlled induction of human pancreatic progenitors produces functional beta-like cells in vitro

21 January 2018

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Human pancreatic beta-like cells converted from fibroblasts

21 January 2018

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Cell lines derived from pancreatic islets

21 January 2018

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Continuous, clonal, insulin- and somatostatin-secreting cell lines established from a transplantable rat islet cell tumor

21 January 2018

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A transplantable insulinoma in the rat

21 January 2018

1 reference

Insulin synthesis in a clonal cell line of simian virus 40-transformed hamster pancreatic beta cells

21 January 2018

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Establishment of 2-mercaptoethanol-dependent differentiated insulin-secreting cell lines

21 January 2018

1 reference

Beta-cell lines derived from transgenic mice expressing a hybrid insulin gene-oncogene

21 January 2018

1 reference

Establishment of a pancreatic beta cell line that retains glucose-inducible insulin secretion: special reference to expression of glucose transporter isoforms

21 January 2018

1 reference

A human beta-cell line for transplantation therapy to control type 1 diabetes.

21 January 2018

1 reference

Gene transfer by retrovirus vectors occurs only in cells that are actively replicating at the time of infection

21 January 2018

1 reference

A genetically engineered human pancreatic β cell line exhibiting glucose-inducible insulin secretion

21 January 2018

1 reference

Development and functional characterization of insulin-releasing human pancreatic beta cell lines produced by electrofusion

21 January 2018

1 reference

Elevated levels of extracellular heat-shock protein 72 (eHSP72) are positively correlated with insulin resistance in vivo and cause pancreatic β-cell dysfunction and death in vitro

21 January 2018

1 reference

Differential effects of interleukin-13 and interleukin-6 on Jak/STAT signaling and cell viability in pancreatic β-cells

21 January 2018

1 reference

Configuration of electrofusion-derived human insulin-secreting cell line as pseudoislets enhances functionality and therapeutic utility

21 January 2018

1 reference

Effects of lipotoxicity on a novel insulin-secreting human pancreatic β-cell line, 1.1B4.

21 January 2018

1 reference

Mechanisms of toxicity by proinflammatory cytokines in a novel human pancreatic beta cell line, 1.1B4.

21 January 2018

1 reference

Kisspeptin prevention of amyloid-β peptide neurotoxicity in vitro

21 January 2018

1 reference

Isolation and characterization of a cell line from the epithelial cells of the human fetal pancreas

21 January 2018

1 reference

Analysis of a human fetal pancreatic islet cell line

21 January 2018

1 reference

Ex vivo analysis of acinar and endocrine cell development in the human embryonic pancreas.

21 January 2018

1 reference

Blood glucose normalization upon transplantation of human embryonic pancreas into beta-cell-deficient SCID mice.

21 January 2018

1 reference

Mouse muscle as an ectopic permissive site for human pancreatic development.

21 January 2018

1 reference

Efficient restricted gene expression in beta cells by lentivirus-mediated gene transfer into pancreatic stem/progenitor cells.

21 January 2018

1 reference

Beta cells within single human islets originate from multiple progenitors

21 January 2018

1 reference

A new strategy to generate functional insulin-producing cell lines by somatic gene transfer into pancreatic progenitors

21 January 2018

1 reference

Development of a conditionally immortalized human pancreatic β cell line.

21 January 2018

1 reference

Dynamic recruitment of functionally distinct Swi/Snf chromatin remodeling complexes modulates Pdx1 activity in islet β cells

21 January 2018

1 reference

MLL3 and MLL4 Methyltransferases Bind to the MAFA and MAFB Transcription Factors to Regulate Islet β-Cell Function

21 January 2018

1 reference

Genetic fine mapping and genomic annotation defines causal mechanisms at type 2 diabetes susceptibility loci

21 January 2018

1 reference

Loss-of-Function Mutations in the Cell-Cycle Control Gene CDKN2A Impact on Glucose Homeostasis in Humans.

21 January 2018

1 reference

Loss of FFA2 and FFA3 increases insulin secretion and improves glucose tolerance in type 2 diabetes.

21 January 2018

1 reference

Innate and adaptive immunity to human beta cell lines: implications for beta cell therapy

21 January 2018

1 reference

A human beta cell line with drug inducible excision of immortalizing transgenes

21 January 2018

1 reference

Human fucci pancreatic Beta cell lines: new tools to study Beta cell cycle and terminal differentiation.

21 January 2018

1 reference

Xenotropic retrovirus Bxv1 in human pancreatic β cell lines.

21 January 2018

1 reference

High-throughput Functional Genomics Identifies Regulators of Primary Human Beta Cell Proliferation.

21 January 2018

1 reference

Pancreatic agenesis attributable to a single nucleotide deletion in the human IPF1 gene coding sequence

21 January 2018

1 reference

Permanent Neonatal Diabetes and Enteric Anendocrinosis Associated With Biallelic Mutations in NEUROG3.

21 January 2018

1 reference

Activating mutations in the ABCC8 gene in neonatal diabetes mellitus

21 January 2018

1 reference

Rfx6 directs islet formation and insulin production in mice and humans

21 January 2018

1 reference

RFX6 regulates insulin secretion by modulating Ca2+ homeostasis in human β cells

21 January 2018

1 reference

An atlas and functional analysis of G-protein coupled receptors in human islets of Langerhans

21 January 2018

1 reference

The biology of incretin hormones

21 January 2018

1 reference

Proton-sensing G-protein-coupled receptors

21 January 2018

1 reference

Pancreatic islet enhancer clusters enriched in type 2 diabetes risk-associated variants

21 January 2018

1 reference

Imatinib mesilate-induced phosphatidylinositol 3-kinase signalling and improved survival in insulin-producing cells: role of Src homology 2-containing inositol 5'-phosphatase interaction with c-Abl

21 January 2018

1 reference

A combined "omics" approach identifies N-Myc interactor as a novel cytokine-induced regulator of IRE1 protein and c-Jun N-terminal kinase in pancreatic beta cells

21 January 2018

1 reference

IL-17A increases the expression of proinflammatory chemokines in human pancreatic islets

21 January 2018

1 reference

BACH2, a candidate risk gene for type 1 diabetes, regulates apoptosis in pancreatic β-cells via JNK1 modulation and crosstalk with the candidate gene PTPN2.

21 January 2018

1 reference

Imatinib mesylate stimulates low-density lipoprotein receptor-related protein 1-mediated ERK phosphorylation in insulin-producing cells

21 January 2018

1 reference

Role of the AMP kinase in cytokine-induced human EndoC-βH1 cell death

21 January 2018

1 reference

TYK2, a Candidate Gene for Type 1 Diabetes, Modulates Apoptosis and the Innate Immune Response in Human Pancreatic β-Cells

21 January 2018

1 reference

The non-canonical NF-κB pathway is induced by cytokines in pancreatic beta cells and contributes to cell death and proinflammatory responses in vitro

21 January 2018

1 reference

Distinct differences in the responses of the human pancreatic β-cell line EndoC-βH1 and human islets to proinflammatory cytokines

21 January 2018

1 reference

Brusatol inhibits the response of cultured beta-cells to pro-inflammatory cytokines in vitro

21 January 2018

1 reference

Human β cell transcriptome analysis uncovers lncRNAs that are tissue-specific, dynamically regulated, and abnormally expressed in type 2 diabetes

21 January 2018

1 reference

Characterization of stimulus-secretion coupling in the human pancreatic EndoC-βH1 beta cell line.

21 January 2018

1 reference

DNA methylation directs functional maturation of pancreatic β cells

21 January 2018

1 reference

Physiological characterization of the human EndoC-βH1 β-cell line

21 January 2018

1 reference

GPR44 is a pancreatic protein restricted to the human beta cell

21 January 2018

1 reference

Calcium signaling in a genetically engineered human pancreatic β-cell line

21 January 2018

1 reference

Lack of Prox1 Downregulation Disrupts the Expansion and Maturation of Postnatal Murine β-Cells

21 January 2018

1 reference

Analysis artefacts of the INS-IGF2 fusion transcript

21 January 2018

1 reference

MafA-Controlled Nicotinic Receptor Expression Is Essential for Insulin Secretion and Is Impaired in Patients with Type 2 Diabetes

21 January 2018

1 reference

Accelerated Maturation of Human Stem Cell-Derived Pancreatic Progenitor Cells into Insulin-Secreting Cells in Immunodeficient Rats Relative to Mice

21 January 2018

1 reference

Extracellular acidification stimulates GPR68 mediated IL-8 production in human pancreatic β cells.

21 January 2018

1 reference

21 January 2018

Identifiers

DOI

10.1111/DOM.12728

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27615142%20AND%20SRC:MED&resulttype=core&format=json

31 May 2020

1 reference