ADCY5 couples glucose to insulin secretion in human islets (Q24294837)

GOA release 2020-03-11

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Vanessa Lavallard

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David J Hodson

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Lorenzo Piemonti

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Piero Marchetti

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Lorella Marselli

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Timothy J Pullen

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Katy L Everett

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Marco Bugliani

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Domenico Bosco

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Guy A. Rutter

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14 June 2020

author name string

Silvia Gimeno Brias

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Francesca Semplici

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Dermot M F Cooper

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Paul R Johnson

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Stephen J Hughes

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Daliang Li

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Wen-Hong Li

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A M James Shapiro

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14 June 2020

language of work or name

English

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publication date

September 2014

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published in

Diabetes

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volume

63

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issue

9

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14 June 2020

page(s)

3009-3021

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The mitochondrial Ca2+ uniporter MCU is essential for glucose-induced ATP increases in pancreatic β-cells

14 June 2020

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Effects of 16 genetic variants on fasting glucose and type 2 diabetes in South Asians: ADCY5 and GLIS3 variants may predispose to type 2 diabetes

19 March 2017

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Adenylyl cyclase 8 is central to glucagon-like peptide 1 signalling and effects of chronically elevated glucose in rat and human pancreatic beta cells

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Genetic variation in GIPR influences the glucose and insulin responses to an oral glucose challenge

19 March 2017

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An improved targeted cAMP sensor to study the regulation of adenylyl cyclase 8 by Ca2+ entry through voltage-gated channels.

6 April 2017

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Lipotoxicity disrupts incretin-regulated human β cell connectivity

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Epigenomic plasticity enables human pancreatic α to β cell reprogramming.

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A local glucagon-like peptide 1 (GLP-1) system in human pancreatic islets.

27 September 2017

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The human pancreatic islet transcriptome: expression of candidate genes for type 1 diabetes and the impact of pro-inflammatory cytokines

27 September 2017

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GLUT2 (SLC2A2) is not the principal glucose transporter in human pancreatic beta cells: implications for understanding genetic association signals at this locus

27 September 2017

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Glucose-raising genetic variants in MADD and ADCY5 impair conversion of proinsulin to insulin

27 September 2017

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Effects of genetic variants in ADCY5, GIPR, GCKR and VPS13C on early impairment of glucose and insulin metabolism in children

27 September 2017

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27 September 2017

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27 September 2017

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27 September 2017

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27 September 2017

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27 September 2017

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27 September 2017

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27 September 2017

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27 September 2017

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27 September 2017

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Limited role for SREBP-1c in defective glucose-induced insulin secretion from Zucker diabetic fatty rat islets: a functional and gene profiling analysis

27 September 2017

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27 September 2017

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Glucose or insulin, but not zinc ions, inhibit glucagon secretion from mouse pancreatic alpha-cells.

27 September 2017

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27 September 2017

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ATP-sensitive K+ channels: a link between B-cell metabolism and insulin secretion

27 September 2017

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Insulin secretion. Interrelationships of glucose, cyclic adenosine 3:5-monophosphate, and calcium

27 September 2017

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Over-expression of sterol-regulatory-element-binding protein-1c (SREBP1c) in rat pancreatic islets induces lipogenesis and decreases glucose-stimulated insulin release: modulation by 5-aminoimidazole-4-carboxamide ribonucleoside (AICAR).

27 September 2017

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Dual effect of glucose on cytoplasmic Ca2+ in single pancreatic beta-cells

30 May 2018

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Adenylate cyclase 5 coordinates the action of ADP, P2Y1, P2Y13 and ATP-gated P2X7 receptors on axonal elongation.

30 May 2018

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Variants at DGKB/TMEM195, ADRA2A, GLIS3 and C2CD4B loci are associated with reduced glucose-stimulated beta cell function in middle-aged Danish people

29 November 2018

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Isolation and culture of mouse pancreatic islets for ex vivo imaging studies with trappable or recombinant fluorescent probes

29 November 2018

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A genetically encoded fluorescent reporter of ATP:ADP ratio

29 November 2018

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Distinct effects of glucose-dependent insulinotropic polypeptide and glucagon-like peptide-1 on insulin secretion and gut motility

29 November 2018

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29 November 2018

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Multiple forms of "kiss-and-run" exocytosis revealed by evanescent wave microscopy

29 November 2018

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29 November 2018

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12 December 2020

Type 5 adenylyl cyclase disruption increases longevity and protects against stress

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Incretin effects of increasing glucose loads in man calculated from venous insulin and C-peptide responses

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Identifiers

DOI

10.2337/DB13-1607

2 references

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24740569%20AND%20SRC:MED&resulttype=core&format=json

14 June 2020

1 reference

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24740569%20AND%20SRC:MED&resulttype=core&format=json

14 June 2020

2 references

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