Protein phosphatase 2A regulates bim expression via the Akt/FKHRL1 signaling pathway in amyloid-beta peptide-induced cerebrovascular endothelial cell death. (Q46958357)

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scientific article published in February 2006

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English	Protein phosphatase 2A regulates bim expression via the Akt/FKHRL1 signaling pathway in amyloid-beta peptide-induced cerebrovascular endothelial cell death.	scientific article published in February 2006

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17 January 2020

Protein phosphatase 2A regulates bim expression via the Akt/FKHRL1 signaling pathway in amyloid-beta peptide-induced cerebrovascular endothelial cell death (English)

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17 January 2020

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17 January 2020

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Xiao-Yan Hu

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Hong Chen

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Sha-Wei Chen

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Jan Xu

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1 February 2006

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17 January 2020

Journal of Neuroscience

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2290-2299

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17 January 2020

Akt promotes cell survival by phosphorylating and inhibiting a Forkhead transcription factor

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https://pubmed.ncbi.nlm.nih.gov/16495456

12 December 2020

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Regulation of protein kinase cascades by protein phosphatase 2A.

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https://pubmed.ncbi.nlm.nih.gov/16495456

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Negative regulation of the forkhead transcription factor FKHR by Akt.

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https://pubmed.ncbi.nlm.nih.gov/16495456

12 December 2020

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Long chain ceramides activate protein phosphatase-1 and protein phosphatase-2A. Activation is stereospecific and regulated by phosphatidic acid

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https://pubmed.ncbi.nlm.nih.gov/16495456

12 December 2020

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Phosphatidic acid is a potent and selective inhibitor of protein phosphatase 1 and an inhibitor of ceramide-mediated responses

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https://pubmed.ncbi.nlm.nih.gov/16495456

12 December 2020

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Role of perivascular cells and myocytes in vascular amyloidosis

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https://pubmed.ncbi.nlm.nih.gov/16495456

12 December 2020

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Insulin-like growth factor-1-induced phosphorylation of the forkhead family transcription factor FKHRL1 is mediated by Akt kinase in PC12 cells

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https://pubmed.ncbi.nlm.nih.gov/16495456

12 December 2020

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Expression of the pro-apoptotic Bcl-2 family member Bim is regulated by the forkhead transcription factor FKHR-L1

1 reference

https://pubmed.ncbi.nlm.nih.gov/16495456

12 December 2020

based on heuristic

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BH3-Only proteins-essential initiators of apoptotic cell death

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https://pubmed.ncbi.nlm.nih.gov/16495456

12 December 2020

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The serine/threonine phosphatase, PP2A: endogenous regulator of inflammatory cell signaling.

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https://pubmed.ncbi.nlm.nih.gov/16495456

12 December 2020

based on heuristic

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Gene structure alternative splicing, and chromosomal localization of pro-apoptotic Bcl-2 relative Bim

1 reference

https://pubmed.ncbi.nlm.nih.gov/16495456

12 December 2020

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inferred from PubMed ID database lookup

Dominant-negative c-Jun promotes neuronal survival by reducing BIM expression and inhibiting mitochondrial cytochrome c release

1 reference

https://pubmed.ncbi.nlm.nih.gov/16495456

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Amyloid beta peptide-induced cerebral endothelial cell death involves mitochondrial dysfunction and caspase activation

1 reference

https://pubmed.ncbi.nlm.nih.gov/16495456

12 December 2020

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Actions of PP2A on the MAP kinase pathway and apoptosis are mediated by distinct regulatory subunits

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https://pubmed.ncbi.nlm.nih.gov/16495456

12 December 2020

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Cell cycle and death control: long live Forkheads

1 reference

https://pubmed.ncbi.nlm.nih.gov/16495456

12 December 2020

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ATM gene regulates oxygen-glucose deprivation-induced nuclear factor-kappaB DNA-binding activity and downstream apoptotic cascade in mouse cerebrovascular endothelial cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/16495456

12 December 2020

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inferred from PubMed ID database lookup

Insulin-like growth factor-I blocks Bcl-2 interacting mediator of cell death (Bim) induction and intrinsic death signaling in cerebellar granule neurons.

1 reference

https://pubmed.ncbi.nlm.nih.gov/16495456

12 December 2020

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Amyloid-beta induces Smac release via AP-1/Bim activation in cerebral endothelial cells.

1 reference

https://pubmed.ncbi.nlm.nih.gov/16495456

12 December 2020

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FOXO transcription factors directly activate bim gene expression and promote apoptosis in sympathetic neurons

1 reference

https://pubmed.ncbi.nlm.nih.gov/16495456

12 December 2020

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Activation of the ERK and JNK signaling pathways caused by neuron-specific inhibition of PP2A in transgenic mice

1 reference

https://pubmed.ncbi.nlm.nih.gov/16495456

12 December 2020

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Apolipoprotein E markedly facilitates age-dependent cerebral amyloid angiopathy and spontaneous hemorrhage in amyloid precursor protein transgenic mice.

1 reference

https://pubmed.ncbi.nlm.nih.gov/16495456

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Matrix metalloproteinase-9 and spontaneous hemorrhage in an animal model of cerebral amyloid angiopathy.

1 reference

https://pubmed.ncbi.nlm.nih.gov/16495456

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Ceramide stimulates a cytosolic protein phosphatase

1 reference

https://pubmed.ncbi.nlm.nih.gov/16495456

12 December 2020

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Receptor-linked hydrolysis of phosphoinositides and production of prostacyclin in cerebral endothelial cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/16495456

12 December 2020

based on heuristic

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Amyloid-beta peptide induces oligodendrocyte death by activating the neutral sphingomyelinase-ceramide pathway

1 reference

https://pubmed.ncbi.nlm.nih.gov/16495456

12 December 2020

based on heuristic

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Neutral sphingomyelinase activation in endothelial and glial cell death induced by amyloid beta-peptide

1 reference

https://pubmed.ncbi.nlm.nih.gov/16495456

12 December 2020

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The c-Jun N-terminal protein kinase signaling pathway mediates Bax activation and subsequent neuronal apoptosis through interaction with Bim after transient focal cerebral ischemia

1 reference

https://pubmed.ncbi.nlm.nih.gov/16495456

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Protein phosphatase 2A negatively regulates insulin's metabolic signaling pathway by inhibiting Akt (protein kinase B) activity in 3T3-L1 adipocytes

1 reference

https://pubmed.ncbi.nlm.nih.gov/16495456

12 December 2020

based on heuristic

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PHLPP: a phosphatase that directly dephosphorylates Akt, promotes apoptosis, and suppresses tumor growth

1 reference

https://pubmed.ncbi.nlm.nih.gov/16495456

12 December 2020

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inferred from PubMed ID database lookup

Constant expression and activity of protein phosphatase 2A in synchronized cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/16495456

12 December 2020

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inferred from PubMed ID database lookup

alpha- and beta-forms of the 65-kDa subunit of protein phosphatase 2A have a similar 39 amino acid repeating structure

1 reference

https://pubmed.ncbi.nlm.nih.gov/16495456

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Neurotoxicity of a fragment of the amyloid precursor associated with Alzheimer's disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/16495456

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The structure and regulation of protein phosphatases

1 reference

https://pubmed.ncbi.nlm.nih.gov/16495456

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Protein phosphatases come of age

1 reference

https://pubmed.ncbi.nlm.nih.gov/16495456

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Molecular cloning of cDNAs encoding two isoforms of the catalytic subunit of protein phosphatase 2A.

1 reference

https://pubmed.ncbi.nlm.nih.gov/16495456

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Rapid sequestration and degradation of somatostatin analogues by isolated brain microvessels.

1 reference

https://pubmed.ncbi.nlm.nih.gov/16495456

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identification of a new family of protein phosphatase 2A regulatory subunits

1 reference

https://pubmed.ncbi.nlm.nih.gov/16495456

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The neuropathology of Alzheimer's disease.

1 reference

https://pubmed.ncbi.nlm.nih.gov/16495456

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The dimeric and catalytic subunit forms of protein phosphatase 2A from rat brain are stimulated by C2-ceramide

1 reference

https://pubmed.ncbi.nlm.nih.gov/16495456

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The protein kinase encoded by the Akt proto-oncogene is a target of the PDGF-activated phosphatidylinositol 3-kinase

1 reference

https://pubmed.ncbi.nlm.nih.gov/16495456

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A novel pool of protein phosphatase 2A is associated with microtubules and is regulated during the cell cycle

1 reference

https://pubmed.ncbi.nlm.nih.gov/16495456

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Hydrogen peroxide mediates amyloid beta protein toxicity

1 reference

https://pubmed.ncbi.nlm.nih.gov/16495456

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Different oligomeric forms of protein phosphatase 2A activate and inhibit simian virus 40 DNA replication

1 reference

https://pubmed.ncbi.nlm.nih.gov/16495456

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Vascular basement membrane components and the lesions of Alzheimer's disease: light and electron microscopic analyses

1 reference

https://pubmed.ncbi.nlm.nih.gov/16495456

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Apoptosis is induced by beta-amyloid in cultured central nervous system neurons

1 reference

https://pubmed.ncbi.nlm.nih.gov/16495456

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Differential expression of Na,K-ATPase alpha and beta subunit isoforms at the blood-brain barrier and the choroid plexus.

1 reference

https://pubmed.ncbi.nlm.nih.gov/16495456

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Ceramide activates heterotrimeric protein phosphatase 2A.

1 reference

https://pubmed.ncbi.nlm.nih.gov/16495456

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Ceramide-activated protein phosphatase: partial purification and relationship to protein phosphatase 2A.

1 reference

https://pubmed.ncbi.nlm.nih.gov/16495456

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Protein serine/threonine phosphatases: structure, regulation, and functions in cell growth

1 reference

https://pubmed.ncbi.nlm.nih.gov/16495456

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Programmed cell death induced by ceramide

1 reference

https://pubmed.ncbi.nlm.nih.gov/16495456

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

High complexity in the expression of the B' subunit of protein phosphatase 2A0. Evidence for the existence of at least seven novel isoforms

1 reference

https://pubmed.ncbi.nlm.nih.gov/16495456

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Ceramide induces apoptosis in cultured mesencephalic neurons.

1 reference

https://pubmed.ncbi.nlm.nih.gov/16495456

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Mechanisms of neuronal degeneration in Alzheimer's disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/16495456

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The B56 family of protein phosphatase 2A (PP2A) regulatory subunits encodes differentiation-induced phosphoproteins that target PP2A to both nucleus and cytoplasm

1 reference

https://pubmed.ncbi.nlm.nih.gov/16495456

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Correlative Memory Deficits, Abeta Elevation, and Amyloid Plaques in Transgenic Mice

1 reference

https://pubmed.ncbi.nlm.nih.gov/16495456

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Assignment of human protein phosphatase 2A regulatory subunit genes b56alpha, b56beta, b56gamma, b56delta, and b56epsilon (PPP2R5A-PPP2R5E), highly expressed in muscle and brain, to chromosome regions 1q41, 11q12, 3p21, 6p21.1, and 7p11.2 --> p12

1 reference

https://pubmed.ncbi.nlm.nih.gov/16495456

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Amyloid beta-peptide induces cell monolayer albumin permeability, impairs glucose transport, and induces apoptosis in vascular endothelial cells.

1 reference

https://pubmed.ncbi.nlm.nih.gov/16495456

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Superoxide free radical and intracellular calcium mediate A beta(1-42) induced endothelial toxicity.

1 reference

https://pubmed.ncbi.nlm.nih.gov/16495456

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

beta-Amyloid induces cerebrovascular endothelial dysfunction in the rat brain.

1 reference

https://pubmed.ncbi.nlm.nih.gov/16495456

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Programmed cell death in cortical chick embryo astrocytes is associated with activation of protein kinase PK60 and ceramide formation.

1 reference

https://pubmed.ncbi.nlm.nih.gov/16495456

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Toxic effects of beta-amyloid(25-35) on immortalised rat brain endothelial cell: protection by carnosine, homocarnosine and beta-alanine

1 reference

https://pubmed.ncbi.nlm.nih.gov/16495456

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Involvement of de novo ceramide biosynthesis in tumor necrosis factor-alpha/cycloheximide-induced cerebral endothelial cell death.

1 reference

https://pubmed.ncbi.nlm.nih.gov/16495456

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Bcl-2-family proteins: the role of the BH3 domain in apoptosis.

1 reference

https://pubmed.ncbi.nlm.nih.gov/16495456

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1523/JNEUROSCI.5103-05.2006

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17 January 2020

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17 January 2020

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:16495456%20AND%20SRC:MED&resulttype=core&format=json

17 January 2020

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