Mechanisms of neuronal degeneration in Alzheimer's disease (Q40986730)

25 September 2017

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title

Mechanisms of neuronal degeneration in Alzheimer's disease (English)

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25 September 2017

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Yankner BA

1

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PubMed ID

8630250

25 September 2017

language of work or name

English

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publication date

1 May 1996

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25 September 2017

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25 September 2017

16

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25 September 2017

921-932

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25 September 2017

5

1 reference

Role of abnormally phosphorylated tau in the breakdown of microtubules in Alzheimer disease

25 September 2017

1 reference

https://api.crossref.org/works/10.1016%2FS0896-6273%2800%2980115-4

7 January 2021

The structure of the presenilin 1 (S182) gene and identification of six novel mutations in early onset AD families

1 reference

https://api.crossref.org/works/10.1016%2FS0896-6273%2800%2980115-4

7 January 2021

Defined neurofilament, tau, and beta-amyloid precursor protein epitopes distinguish Alzheimer from non-Alzheimer senile plaques.

1 reference

https://api.crossref.org/works/10.1016%2FS0896-6273%2800%2980115-4

7 January 2021

Giant multilevel cation channels formed by Alzheimer disease amyloid beta-protein [A beta P-(1-40)] in bilayer membranes

1 reference

https://api.crossref.org/works/10.1016%2FS0896-6273%2800%2980115-4

7 January 2021

Solution Structures of β Peptide and Its Constituent Fragments: Relation to Amyloid Deposition

1 reference

https://api.crossref.org/works/10.1016%2FS0896-6273%2800%2980115-4

7 January 2021

The cholinergic hypothesis of geriatric memory dysfunction

1 reference

https://api.crossref.org/works/10.1016%2FS0896-6273%2800%2980115-4

7 January 2021

Hydrogen peroxide mediates amyloid beta protein toxicity

1 reference

https://api.crossref.org/works/10.1016%2FS0896-6273%2800%2980115-4

7 January 2021

Phosphorylation of Ser262 strongly reduces binding of tau to microtubules: distinction between PHF-like immunoreactivity and microtubule binding.

1 reference

https://api.crossref.org/works/10.1016%2FS0896-6273%2800%2980115-4

7 January 2021

Abnormal tau phosphorylation at Ser396 in Alzheimer's disease recapitulates development and contributes to reduced microtubule binding.

1 reference

https://api.crossref.org/works/10.1016%2FS0896-6273%2800%2980115-4

7 January 2021

Beta amyloid precursor protein mediates neuronal cell-cell and cell-surface adhesion

1 reference

https://api.crossref.org/works/10.1016%2FS0896-6273%2800%2980115-4

7 January 2021

Inverse association of anti-inflammatory treatments and Alzheimer's disease: initial results of a co-twin control study.

1 reference

https://api.crossref.org/works/10.1016%2FS0896-6273%2800%2980115-4

7 January 2021

Amyotrophic lateral sclerosis: recent insights from genetics and transgenic mice

1 reference

https://api.crossref.org/works/10.1016%2FS0896-6273%2800%2980115-4

7 January 2021

Apoptosis and increased generation of reactive oxygen species in Down's syndrome neurons in vitro.

1 reference

https://api.crossref.org/works/10.1016%2FS0896-6273%2800%2980115-4

7 January 2021

Methodological variables in the assessment of beta amyloid neurotoxicity

1 reference

https://api.crossref.org/works/10.1016%2FS0896-6273%2800%2980115-4

7 January 2021

Generation of beta-amyloid in the secretory pathway in neuronal and nonneuronal cells

1 reference

https://api.crossref.org/works/10.1016%2FS0896-6273%2800%2980115-4

7 January 2021

beta-Amyloid neurotoxicity in human cortical culture is not mediated by excitotoxins

1 reference

https://api.crossref.org/works/10.1016%2FS0896-6273%2800%2980115-4

7 January 2021

beta-amyloid fibrils induce tau phosphorylation and loss of microtubule binding.

1 reference

https://api.crossref.org/works/10.1016%2FS0896-6273%2800%2980115-4

7 January 2021

Rapid induction of Alzheimer A beta amyloid formation by zinc.

1 reference

https://api.crossref.org/works/10.1016%2FS0896-6273%2800%2980115-4

7 January 2021

Release of excess amyloid beta protein from a mutant amyloid beta protein precursor.

1 reference

https://api.crossref.org/works/10.1016%2FS0896-6273%2800%2980115-4

7 January 2021

Gene expression and cellular content of cathepsin D in Alzheimer's disease brain: evidence for early up-regulation of the endosomal-lysosomal system.

1 reference

https://api.crossref.org/works/10.1016%2FS0896-6273%2800%2980115-4

7 January 2021

Potent inhibition of scrapie-associated PrP accumulation by congo red

1 reference

https://api.crossref.org/works/10.1016%2FS0896-6273%2800%2980115-4

7 January 2021

An antibody to beta amyloid and the amyloid precursor protein inhibits cell-substratum adhesion in many mammalian cell types

1 reference

https://api.crossref.org/works/10.1016%2FS0896-6273%2800%2980115-4

7 January 2021

Mutation of the beta-amyloid precursor protein in familial Alzheimer's disease increases beta-protein production

1 reference

https://api.crossref.org/works/10.1016%2FS0896-6273%2800%2980115-4

7 January 2021

B- Amyloid increases neuronal susceptibility to injufy by glucose deprivation

1 reference

https://api.crossref.org/works/10.1016%2FS0896-6273%2800%2980115-4

7 January 2021

Protective effect of apolipoprotein E type 2 allele for late onset Alzheimer disease

1 reference

https://api.crossref.org/works/10.1016%2FS0896-6273%2800%2980115-4

7 January 2021

Oxidative stress, glutamate, and neurodegenerative disorders

1 reference

https://api.crossref.org/works/10.1016%2FS0896-6273%2800%2980115-4

7 January 2021

apl-1, a Caenorhabditis elegans gene encoding a protein related to the human beta-amyloid protein precursor

1 reference

https://api.crossref.org/works/10.1016%2FS0896-6273%2800%2980115-4

7 January 2021

Selective loss of central cholinergic neurons in Alzheimer's disease

1 reference

https://api.crossref.org/works/10.1016%2FS0896-6273%2800%2980115-4

7 January 2021

Grafting of nerve growth factor-producing fibroblasts reduces behavioral deficits in rats with lesions of the nucleus basalis magnocellularis

1 reference

https://api.crossref.org/works/10.1016%2FS0896-6273%2800%2980115-4

7 January 2021

Identification of normal and pathological aging in prospectively studied nondemented elderly humans

1 reference

https://api.crossref.org/works/10.1016%2FS0896-6273%2800%2980115-4

7 January 2021

Cleavage of amyloid beta peptide during constitutive processing of its precursor

1 reference

https://api.crossref.org/works/10.1016%2FS0896-6273%2800%2980115-4

7 January 2021

Solubilization of beta-amyloid-(1-42)-peptide: reversing the beta-sheet conformation induced by aluminum with silicates

1 reference

https://api.crossref.org/works/10.1016%2FS0896-6273%2800%2980115-4

7 January 2021

Neurotoxicity of a prion protein fragment.

1 reference

https://api.crossref.org/works/10.1016%2FS0896-6273%2800%2980115-4

7 January 2021

Apoptosis mediated neurotoxicity induced by chronic application of beta amyloid fragment 25-35.

1 reference

https://api.crossref.org/works/10.1016%2FS0896-6273%2800%2980115-4

7 January 2021

Effects of sulfate ions on Alzheimer beta/A4 peptide assemblies: implications for amyloid fibril-proteoglycan interactions

1 reference

https://api.crossref.org/works/10.1016%2FS0896-6273%2800%2980115-4

7 January 2021

Effects of injected Alzheimer beta-amyloid cores in rat brain.

1 reference

https://api.crossref.org/works/10.1016%2FS0896-6273%2800%2980115-4

7 January 2021

Activation of K+ channels and suppression of neuronal activity by secreted beta-amyloid-precursor protein.

1 reference

https://api.crossref.org/works/10.1016%2FS0896-6273%2800%2980115-4

7 January 2021

Alzheimer-type neuropathology in transgenic mice overexpressing V717F β-amyloid precursor protein

1 reference

https://api.crossref.org/works/10.1016%2FS0896-6273%2800%2980115-4

7 January 2021

Differential effects of amyloid peptides beta-(1-40) and beta-(25-35) injections into the rat nucleus basalis.

1 reference

https://api.crossref.org/works/10.1016%2FS0896-6273%2800%2980115-4

7 January 2021

Alzheimer's disease: Initial report of the purification and characterization of a novel cerebrovascular amyloid protein

1 reference

https://api.crossref.org/works/10.1016%2FS0896-6273%2800%2980115-4

7 January 2021

Segregation of a missense mutation in the amyloid precursor protein gene with familial Alzheimer's disease

1 reference

https://api.crossref.org/works/10.1016%2FS0896-6273%2800%2980115-4

7 January 2021

Tau protein and the neurofibrillary pathology of Alzheimer's disease

1 reference

https://api.crossref.org/works/10.1016%2FS0896-6273%2800%2980115-4

7 January 2021

Secreted beta-amyloid precursor protein stimulates mitogen-activated protein kinase and enhances tau phosphorylation.

1 reference

https://api.crossref.org/works/10.1016%2FS0896-6273%2800%2980115-4

7 January 2021

Superoxide dismutase delays neuronal apoptosis: a role for reactive oxygen species in programmed neuronal death

1 reference

https://api.crossref.org/works/10.1016%2FS0896-6273%2800%2980115-4

7 January 2021

Amyloid beta-peptide is produced by cultured cells during normal metabolism

1 reference

https://api.crossref.org/works/10.1016%2FS0896-6273%2800%2980115-4

7 January 2021

Apolipoprotein E is localized to the cytoplasm of human cortical neurons: a light and electron microscopic study

1 reference

https://api.crossref.org/works/10.1016%2FS0896-6273%2800%2980115-4

7 January 2021

A model for beta-amyloid aggregation and neurotoxicity based on free radical generation by the peptide: relevance to Alzheimer disease

1 reference

https://api.crossref.org/works/10.1016%2FS0896-6273%2800%2980115-4

7 January 2021

Transgenic mouse brain histopathology resembles early Alzheimer's disease.

1 reference

https://api.crossref.org/works/10.1016%2FS0896-6273%2800%2980115-4

7 January 2021

Aggregation state and neurotoxic properties of Alzheimer beta-amyloid peptide

1 reference

https://api.crossref.org/works/10.1016%2FS0896-6273%2800%2980115-4

7 January 2021

Expression of apolipoprotein E during nerve degeneration and regeneration

1 reference

https://api.crossref.org/works/10.1016%2FS0896-6273%2800%2980115-4

7 January 2021

Visualization of A beta 42(43) and A beta 40 in senile plaques with end-specific A beta monoclonals: evidence that an initially deposited species is A beta 42(43).

1 reference

https://api.crossref.org/works/10.1016%2FS0896-6273%2800%2980115-4

7 January 2021

Seeding "one-dimensional crystallization" of amyloid: a pathogenic mechanism in Alzheimer's disease and scrapie?

1 reference

https://api.crossref.org/works/10.1016%2FS0896-6273%2800%2980115-4

7 January 2021

Bcl-2 inhibition of neural death: decreased generation of reactive oxygen species

1 reference

https://api.crossref.org/works/10.1016%2FS0896-6273%2800%2980115-4

7 January 2021

The precursor of Alzheimer's disease amyloid A4 protein resembles a cell-surface receptor

1 reference

https://api.crossref.org/works/10.1016%2FS0896-6273%2800%2980115-4

7 January 2021

Clinical, pathological, and neurochemical changes in dementia: A subgroup with preserved mental status and numerous neocortical plaques

1 reference

https://api.crossref.org/works/10.1016%2FS0896-6273%2800%2980115-4

7 January 2021

beta-Amyloid precursor protein binds to the neurite-promoting IKVAV site of laminin

1 reference

https://api.crossref.org/works/10.1016%2FS0896-6273%2800%2980115-4

7 January 2021

Arresting amyloidosis in vivo using small-molecule anionic sulphonates or sulphates: implications for Alzheimer's disease.

1 reference

https://api.crossref.org/works/10.1016%2FS0896-6273%2800%2980115-4

7 January 2021

Novel precursor of Alzheimer's disease amyloid protein shows protease inhibitory activity

1 reference

https://api.crossref.org/works/10.1016%2FS0896-6273%2800%2980115-4

7 January 2021

Beta-amyloid protein increases the vulnerability of cultured cortical neurons to excitotoxic damage

1 reference

https://api.crossref.org/works/10.1016%2FS0896-6273%2800%2980115-4

7 January 2021

Biologic Effects of Nerve Growth Factor on Lesioned Basal Forebrain Neuronsa

1 reference

https://api.crossref.org/works/10.1016%2FS0896-6273%2800%2980115-4

7 January 2021

Precursor of amyloid protein in Alzheimer disease undergoes fast anterograde axonal transport

1 reference

https://api.crossref.org/works/10.1016%2FS0896-6273%2800%2980115-4

7 January 2021

Alzheimer-associated presenilins 1 and 2: neuronal expression in brain and localization to intracellular membranes in mammalian cells.

1 reference

https://api.crossref.org/works/10.1016%2FS0896-6273%2800%2980115-4

7 January 2021

An in vivo model for the neurodegenerative effects of beta amyloid and protection by substance P

1 reference

https://api.crossref.org/works/10.1016%2FS0896-6273%2800%2980115-4

7 January 2021

Introduction and expression of the 400 kilobase amyloid precursor protein gene in transgenic mice [corrected]

1 reference

https://api.crossref.org/works/10.1016%2FS0896-6273%2800%2980115-4

7 January 2021

Cell death in Alzheimer's disease evaluated by DNA fragmentation in situ

1 reference

https://api.crossref.org/works/10.1016%2FS0896-6273%2800%2980115-4

7 January 2021

Facilitation of lin-12-mediated signalling by sel-12, a Caenorhabditis elegans S182 Alzheimer's disease gene

1 reference

https://api.crossref.org/works/10.1016%2FS0896-6273%2800%2980115-4

7 January 2021

Mutation of the Alzheimer's disease amyloid gene in hereditary cerebral hemorrhage, Dutch type.

1 reference

https://api.crossref.org/works/10.1016%2FS0896-6273%2800%2980115-4

7 January 2021

Candidate gene for the chromosome 1 familial Alzheimer's disease locus

1 reference

https://api.crossref.org/works/10.1016%2FS0896-6273%2800%2980115-4

7 January 2021

Mutation of a putative sperm membrane protein in Caenorhabditis elegans prevents sperm differentiation but not its associated meiotic divisions

1 reference

https://api.crossref.org/works/10.1016%2FS0896-6273%2800%2980115-4

7 January 2021

Identification and expression analysis of a potential familial Alzheimer disease gene on chromosome 1 related to AD3.

1 reference

https://api.crossref.org/works/10.1016%2FS0896-6273%2800%2980115-4

7 January 2021

Inhibitors of free radical formation fail to attenuate direct beta-amyloid25-35 peptide-mediated neurotoxicity in rat hippocampal cultures.

1 reference

https://api.crossref.org/works/10.1016%2FS0896-6273%2800%2980115-4

7 January 2021

Apoptosis is induced by beta-amyloid in cultured central nervous system neurons

1 reference

https://api.crossref.org/works/10.1016%2FS0896-6273%2800%2980115-4

7 January 2021

Beta-amyloid neurotoxicity requires fibril formation and is inhibited by congo red.

1 reference

https://api.crossref.org/works/10.1016%2FS0896-6273%2800%2980115-4

7 January 2021

Pancreatic islet cell toxicity of amylin associated with type-2 diabetes mellitus

1 reference

https://api.crossref.org/works/10.1016%2FS0896-6273%2800%2980115-4

7 January 2021

Functional studies of Alzheimer's disease tau protein.

1 reference

https://api.crossref.org/works/10.1016%2FS0896-6273%2800%2980115-4

7 January 2021

Human amyloid precursor protein ameliorates behavioral deficit of flies deleted for Appl gene

1 reference

https://api.crossref.org/works/10.1016%2FS0896-6273%2800%2980115-4

7 January 2021

Amyloid-associated proteins α1-antichymotrypsin and apolipoprotein E promote assembly of Alzheimer β-protein into filaments

1 reference

https://api.crossref.org/works/10.1016%2FS0896-6273%2800%2980115-4

7 January 2021

Reversible in vitro growth of Alzheimer disease beta-amyloid plaques by deposition of labeled amyloid peptide

1 reference

https://api.crossref.org/works/10.1016%2FS0896-6273%2800%2980115-4

7 January 2021

Apolipoprotein E: cholesterol transport protein with expanding role in cell biology

1 reference

https://api.crossref.org/works/10.1016%2FS0896-6273%2800%2980115-4

7 January 2021

The pattern of acquisition of plaques and tangles in the brains of patients under 50 years of age with Down's syndrome

1 reference

https://api.crossref.org/works/10.1016%2FS0896-6273%2800%2980115-4

7 January 2021

Aluminum, iron, and zinc ions promote aggregation of physiological concentrations of beta-amyloid peptide.

1 reference

https://api.crossref.org/works/10.1016%2FS0896-6273%2800%2980115-4

7 January 2021

Human nerve growth factor improves spatial memory in aged but not in young rats.

1 reference

https://api.crossref.org/works/10.1016%2FS0896-6273%2800%2980115-4

7 January 2021

Amyloid plaque core protein in Alzheimer disease and Down syndrome

1 reference

https://api.crossref.org/works/10.1016%2FS0896-6273%2800%2980115-4

7 January 2021

Different amyloidogenic peptides share a similar mechanism of neurotoxicity involving reactive oxygen species and calcium

1 reference

https://api.crossref.org/works/10.1016%2FS0896-6273%2800%2980115-4

7 January 2021

beta-Amyloid peptides destabilize calcium homeostasis and render human cortical neurons vulnerable to excitotoxicity

1 reference

https://api.crossref.org/works/10.1016%2FS0896-6273%2800%2980115-4

7 January 2021

Evidence for excitoprotective and intraneuronal calcium-regulating roles for secreted forms of the beta-amyloid precursor protein.

1 reference

https://api.crossref.org/works/10.1016%2FS0896-6273%2800%2980115-4

7 January 2021

Calcium-destabilizing and neurodegenerative effects of aggregated beta-amyloid peptide are attenuated by basic FGF.

1 reference

https://api.crossref.org/works/10.1016%2FS0896-6273%2800%2980115-4

7 January 2021

beta-Amyloid peptide in vitro toxicity: lot-to-lot variability

1 reference

https://api.crossref.org/works/10.1016%2FS0896-6273%2800%2980115-4

7 January 2021

Neurotoxicity of human amylin in rat primary hippocampal cultures: similarity to Alzheimer's disease amyloid-beta neurotoxicity

1 reference

https://api.crossref.org/works/10.1016%2FS0896-6273%2800%2980115-4

7 January 2021

Neuroimmune mechanisms in Alzheimer disease pathogenesis

1 reference

https://api.crossref.org/works/10.1016%2FS0896-6273%2800%2980115-4

7 January 2021

Oxidative damage to mitochondrial DNA is increased in Alzheimer's disease

1 reference

https://api.crossref.org/works/10.1016%2FS0896-6273%2800%2980115-4

7 January 2021

Activation of microglial cells by beta-amyloid protein and interferon-gamma.

1 reference

https://api.crossref.org/works/10.1016%2FS0896-6273%2800%2980115-4

7 January 2021

Butyrylcholinesterase reactivity differentiates the amyloid plaques of aging from those of dementia.

1 reference

https://api.crossref.org/works/10.1016%2FS0896-6273%2800%2980115-4

7 January 2021

The amyloid protein precursor of Alzheimer's disease is a mediator of the effects of nerve growth factor on neurite outgrowth.

1 reference

https://api.crossref.org/works/10.1016%2FS0896-6273%2800%2980115-4

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0896-6273%2800%2980115-4

7 January 2021

Very mild Alzheimer's disease: informant-based clinical, psychometric, and pathologic distinction from normal aging.

1 reference

https://api.crossref.org/works/10.1016%2FS0896-6273%2800%2980115-4

7 January 2021

Synaptotrophic effects of human amyloid β protein precursors in the cortex of transgenic mice

1 reference

https://api.crossref.org/works/10.1016%2FS0896-6273%2800%2980115-4

7 January 2021

Protection against HIV-1 gp120-induced brain damage by neuronal expression of human amyloid precursor protein

1 reference

https://api.crossref.org/works/10.1016%2FS0896-6273%2800%2980115-4

7 January 2021

A pathogenic mutation for probable Alzheimer's disease in the APP gene at the N-terminus of beta-amyloid

1 reference

https://api.crossref.org/works/10.1016%2FS0896-6273%2800%2980115-4

7 January 2021

Behavioral and anatomical deficits in mice homozygous for a modified beta-amyloid precursor protein gene

1 reference

https://api.crossref.org/works/10.1016%2FS0896-6273%2800%2980115-4

7 January 2021

Apolipoprotein E immunoreactivity in cerebral amyloid deposits and neurofibrillary tangles in Alzheimer's disease and kuru plaque amyloid in Creutzfeldt-Jakob disease.

1 reference

https://api.crossref.org/works/10.1016%2FS0896-6273%2800%2980115-4

7 January 2021

Characterization of stable complexes involving apolipoprotein E and the amyloid beta peptide in Alzheimer's disease brain.

1 reference

https://api.crossref.org/works/10.1016%2FS0896-6273%2800%2980115-4

7 January 2021

Differential effects of apolipoproteins E3 and E4 on neuronal growth in vitro

1 reference

https://api.crossref.org/works/10.1016%2FS0896-6273%2800%2980115-4

7 January 2021

Neurofibrillary tangles in the cerebral cortex of sheep

1 reference

https://api.crossref.org/works/10.1016%2FS0896-6273%2800%2980115-4

7 January 2021

Alzheimer amyloid protein precursor complexes with brain GTP-binding protein G(o)

1 reference

https://api.crossref.org/works/10.1016%2FS0896-6273%2800%2980115-4

7 January 2021

In vitro aging of beta-amyloid protein causes peptide aggregation and neurotoxicity

1 reference

https://api.crossref.org/works/10.1016%2FS0896-6273%2800%2980115-4

7 January 2021

Neurodegeneration induced by beta-amyloid peptides in vitro: the role of peptide assembly state

1 reference

https://api.crossref.org/works/10.1016%2FS0896-6273%2800%2980115-4

7 January 2021

Aggregation of secreted amyloid beta-protein into sodium dodecyl sulfate-stable oligomers in cell culture

1 reference

https://api.crossref.org/works/10.1016%2FS0896-6273%2800%2980115-4

7 January 2021

Apolipoprotein E in animal models of CNS injury and in Alzheimer's disease

1 reference

https://api.crossref.org/works/10.1016%2FS0896-6273%2800%2980115-4

7 January 2021

Astrocytic apolipoprotein E mRNA and GFAP mRNA in hippocampus after entorhinal cortex lesioning

1 reference

https://api.crossref.org/works/10.1016%2FS0896-6273%2800%2980115-4

7 January 2021

Sulfated glycosaminoglycans and dyes attenuate the neurotoxic effects of beta-amyloid in rat PC12 cells.

1 reference

https://api.crossref.org/works/10.1016%2FS0896-6273%2800%2980115-4

7 January 2021

Apolipoprotein E, Dementia, and Cortical Deposition of β-Amyloid Protein

1 reference

https://api.crossref.org/works/10.1016%2FS0896-6273%2800%2980115-4

7 January 2021

A new A4 amyloid mRNA contains a domain homologous to serine proteinase inhibitors

1 reference

https://api.crossref.org/works/10.1016%2FS0896-6273%2800%2980115-4

7 January 2021

Formation of beta-amyloid protein deposits in brains of transgenic mice

1 reference

https://api.crossref.org/works/10.1016%2FS0896-6273%2800%2980115-4

7 January 2021

Apolipoprotein E in sporadic Alzheimer's disease: allelic variation and receptor interactions

1 reference

https://api.crossref.org/works/10.1016%2FS0896-6273%2800%2980115-4

7 January 2021

Familial Alzheimer's disease in kindreds with missense mutations in a gene on chromosome 1 related to the Alzheimer's disease type 3 gene

1 reference

https://api.crossref.org/works/10.1016%2FS0896-6273%2800%2980115-4

7 January 2021

Complement activation by beta-amyloid in Alzheimer disease

1 reference

https://api.crossref.org/works/10.1016%2FS0896-6273%2800%2980115-4

7 January 2021

Clinical trial of indomethacin in Alzheimer's disease.

1 reference

https://api.crossref.org/works/10.1016%2FS0896-6273%2800%2980115-4

7 January 2021

Beta-amyloid from Alzheimer disease brains inhibits sprouting and survival of sympathetic neurons.

1 reference

https://api.crossref.org/works/10.1016%2FS0896-6273%2800%2980115-4

7 January 2021

Apolipoprotein E epsilon 2 allele promotes longevity and protects patients with Down's syndrome from dementia

1 reference

https://api.crossref.org/works/10.1016%2FS0896-6273%2800%2980115-4

7 January 2021

Amyloid A4 protein and its precursor in Down's syndrome and Alzheimer's disease.

1 reference

https://api.crossref.org/works/10.1016%2FS0896-6273%2800%2980115-4

7 January 2021

Secreted form of amyloid beta protein precursor is involved in the growth regulation of fibroblasts.

1 reference

https://api.crossref.org/works/10.1016%2FS0896-6273%2800%2980115-4

7 January 2021

Apolipoprotein E associates with beta amyloid peptide of Alzheimer's disease to form novel monofibrils. Isoform apoE4 associates more efficiently than apoE3

1 reference

https://api.crossref.org/works/10.1016%2FS0896-6273%2800%2980115-4

7 January 2021

Genetic linkage evidence for a familial Alzheimer's disease locus on chromosome 14

1 reference

https://api.crossref.org/works/10.1016%2FS0896-6273%2800%2980115-4

7 January 2021

Increased amyloid beta-peptide deposition in cerebral cortex as a consequence of apolipoprotein E genotype in late-onset Alzheimer disease

1 reference

https://api.crossref.org/works/10.1016%2FS0896-6273%2800%2980115-4

7 January 2021

The expression of amyloid beta protein precursor protects nerve cells from beta-amyloid and glutamate toxicity and alters their interaction with the extracellular matrix

1 reference

https://api.crossref.org/works/10.1016%2FS0896-6273%2800%2980115-4

7 January 2021

The regulation of amyloid beta protein precursor secretion and its modulatory role in cell adhesion

1 reference

https://api.crossref.org/works/10.1016%2FS0896-6273%2800%2980115-4

7 January 2021

Oxidation of cysteine-322 in the repeat domain of microtubule-associated protein tau controls the in vitro assembly of paired helical filaments

1 reference

https://api.crossref.org/works/10.1016%2FS0896-6273%2800%2980115-4

7 January 2021

Cell biology of the amyloid beta-protein precursor and the mechanism of Alzheimer's disease

1 reference

https://api.crossref.org/works/10.1016%2FS0896-6273%2800%2980115-4

7 January 2021

Isolation and quantification of soluble Alzheimer's beta-peptide from biological fluids

1 reference

https://api.crossref.org/works/10.1016%2FS0896-6273%2800%2980115-4

7 January 2021

Inhibition of PC12 cell redox activity is a specific, early indicator of the mechanism of beta-amyloid-mediated cell death

1 reference

https://api.crossref.org/works/10.1016%2FS0896-6273%2800%2980115-4

7 January 2021

Cloning of a gene bearing missense mutations in early-onset familial Alzheimer's disease

1 reference

https://api.crossref.org/works/10.1016%2FS0896-6273%2800%2980115-4

7 January 2021

Alzheimer disease A68 proteins injected into rat brain induce codeposits of beta-amyloid, ubiquitin, and alpha 1-antichymotrypsin

1 reference

https://api.crossref.org/works/10.1016%2FS0896-6273%2800%2980115-4

7 January 2021

Production of the Alzheimer amyloid beta protein by normal proteolytic processing

1 reference

https://api.crossref.org/works/10.1016%2FS0896-6273%2800%2980115-4

7 January 2021

Evidence that beta-amyloid protein in Alzheimer's disease is not derived by normal processing

1 reference

https://api.crossref.org/works/10.1016%2FS0896-6273%2800%2980115-4

7 January 2021

Excess brain protein oxidation and enzyme dysfunction in normal aging and in Alzheimer disease

1 reference

https://api.crossref.org/works/10.1016%2FS0896-6273%2800%2980115-4

7 January 2021

Advanced Maillard reaction end products are associated with Alzheimer disease pathology

1 reference

https://api.crossref.org/works/10.1016%2FS0896-6273%2800%2980115-4

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0896-6273%2800%2980115-4

7 January 2021

An important role of heparan sulfate proteoglycan (Perlecan) in a model system for the deposition and persistence of fibrillar A beta-amyloid in rat brain

1 reference

https://api.crossref.org/works/10.1016%2FS0896-6273%2800%2980115-4

7 January 2021

Genetic evidence for a novel familial Alzheimer's disease locus on chromosome 14.

1 reference

https://api.crossref.org/works/10.1016%2FS0896-6273%2800%2980115-4

7 January 2021

Apolipoprotein E: high-avidity binding to beta-amyloid and increased frequency of type 4 allele in late-onset familial Alzheimer disease

1 reference

https://api.crossref.org/works/10.1016%2FS0896-6273%2800%2980115-4

7 January 2021

Binding of human apolipoprotein E to synthetic amyloid beta peptide: isoform-specific effects and implications for late-onset Alzheimer disease

1 reference

https://api.crossref.org/works/10.1016%2FS0896-6273%2800%2980115-4

7 January 2021

Isoform-specific interactions of apolipoprotein E with microtubule-associated protein tau: implications for Alzheimer disease

1 reference

https://api.crossref.org/works/10.1016%2FS0896-6273%2800%2980115-4

7 January 2021

Immunohistochemical evidence for apoptosis in Alzheimer's disease.

1 reference

https://api.crossref.org/works/10.1016%2FS0896-6273%2800%2980115-4

7 January 2021

Autopsy samples of Alzheimer's cortex show increased peroxidation in vitro

1 reference

https://api.crossref.org/works/10.1016%2FS0896-6273%2800%2980115-4

7 January 2021

An increased percentage of long amyloid beta protein secreted by familial amyloid beta protein precursor (beta APP717) mutants.

1 reference

https://api.crossref.org/works/10.1016%2FS0896-6273%2800%2980115-4

7 January 2021

Protease inhibitor domain encoded by an amyloid protein precursor mRNA associated with Alzheimer's disease

1 reference

https://api.crossref.org/works/10.1016%2FS0896-6273%2800%2980115-4

7 January 2021

Physical basis of cognitive alterations in alzheimer's disease: Synapse loss is the major correlate of cognitive impairment

1 reference

https://api.crossref.org/works/10.1016%2FS0896-6273%2800%2980115-4

7 January 2021

Distribution of an APP homolog, APLP2, in the mouse olfactory system: a potential role for APLP2 in axogenesis.

1 reference

https://api.crossref.org/works/10.1016%2FS0896-6273%2800%2980115-4

7 January 2021

Recombinant human nerve growth factor infusions prevent cholinergic neuronal degeneration in the adult primate brain

1 reference

https://api.crossref.org/works/10.1016%2FS0896-6273%2800%2980115-4

7 January 2021

Decreased levels of soluble amyloid beta-protein precursor in cerebrospinal fluid of live Alzheimer disease patients

1 reference

https://api.crossref.org/works/10.1016%2FS0896-6273%2800%2980115-4

7 January 2021

Advanced glycation end products contribute to amyloidosis in Alzheimer disease

1 reference

https://api.crossref.org/works/10.1016%2FS0896-6273%2800%2980115-4

7 January 2021

Interfering with apoptosis: Ca(2+)-binding protein ALG-2 and Alzheimer's disease gene ALG-3

1 reference

https://api.crossref.org/works/10.1016%2FS0896-6273%2800%2980115-4

7 January 2021

Identification of a mouse brain cDNA that encodes a protein related to the Alzheimer disease-associated amyloid beta protein precursor

1 reference

https://api.crossref.org/works/10.1016%2FS0896-6273%2800%2980115-4

7 January 2021

Isolation and characterization of APLP2 encoding a homologue of the Alzheimer's associated amyloid beta protein precursor

1 reference

https://api.crossref.org/works/10.1016%2FS0896-6273%2800%2980115-4

7 January 2021

Familial Alzheimer's chromosome 14 mutations.

1 reference

https://api.crossref.org/works/10.1016%2FS0896-6273%2800%2980115-4

7 January 2021

Identification, biogenesis, and localization of precursors of Alzheimer's disease A4 amyloid protein.

1 reference

https://api.crossref.org/works/10.1016%2FS0896-6273%2800%2980115-4

7 January 2021

Alzheimer's disease and senile dementia: loss of neurons in the basal forebrain

1 reference

https://api.crossref.org/works/10.1016%2FS0896-6273%2800%2980115-4

7 January 2021

Neurotoxicity of A beta amyloid protein in vitro is not altered by calcium channel blockade

1 reference

https://api.crossref.org/works/10.1016%2FS0896-6273%2800%2980115-4

7 January 2021

Apolipoprotein E: a pathological chaperone protein in patients with cerebral and systemic amyloid

1 reference

https://api.crossref.org/works/10.1016%2FS0896-6273%2800%2980115-4

7 January 2021

Peptides homologous to the amyloid protein of Alzheimer's disease containing a glutamine for glutamic acid substitution have accelerated amyloid fibril formation.

1 reference

https://api.crossref.org/works/10.1016%2FS0896-6273%2800%2980115-4

7 January 2021

Ultrastructural characterization of cerebellar diffuse plaques in Alzheimer's disease

1 reference

https://api.crossref.org/works/10.1016%2FS0896-6273%2800%2980115-4

7 January 2021

Trafficking of cell surface beta-amyloid precursor protein: retrograde and transcytotic transport in cultured neurons

1 reference

https://api.crossref.org/works/10.1016%2FS0896-6273%2800%2980115-4

7 January 2021

Neurotoxicity of a fragment of the amyloid precursor associated with Alzheimer's disease

1 reference

https://api.crossref.org/works/10.1016%2FS0896-6273%2800%2980115-4

7 January 2021

Neurotrophic and neurotoxic effects of amyloid beta protein: reversal by tachykinin neuropeptides

1 reference

https://api.crossref.org/works/10.1016%2FS0896-6273%2800%2980115-4

7 January 2021

Nerve growth factor potentiates the neurotoxicity of beta amyloid

1 reference

https://api.crossref.org/works/10.1016%2FS0896-6273%2800%2980115-4

7 January 2021

beta-Amyloid precursor protein-deficient mice show reactive gliosis and decreased locomotor activity

1 reference

https://api.crossref.org/works/10.1016%2FS0896-6273%2800%2980115-4

7 January 2021

10.1016/S0896-6273(00)80115-4

Identifiers

DOI

1 reference

25 September 2017

1 reference

PubMed ID

8630250