Re-evaluation of sodium nitrate (E 251) and potassium nitrate (E 252) as food additives (Q46394883)

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Alicja Mortensen

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Agneta Oskarsson

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EFSA Panel On Food Additives And Nutrient Sources Added To Food

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Efsa Panel On Food Additives And Nutrient Sources Added To Food (ans)

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EFSA Panel on Food Additives and Nutrient Sources added to Food (ANS)

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Ursula Gundert-Remy

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Maged Younes

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Ine Waalkens-Berendsen

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Ine Waalkens-Berendsen

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Peter Moldeus

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Pasquale Mosesso

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Claude Lambré

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Anna Christodoulidou

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Oliver Lindtner

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Rudolf Antonius Woutersen

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Leonardo Merino

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Fernando Aguilar

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Alessandro Di Domenico

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Maria Jose Frutos

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Pierre Galtier

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Ivan Stankovic

18

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Matthew Wright

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Cristina Fortes

23

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Fidel Toldrà

25

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Ana Garcia

29

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external data available at URL

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EFSA Journal

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volume

15

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6

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Dietary factors and risk of pancreatic cancer: results of a Canadian population-based case-control study

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Effects of sub-chronic nitrate exposure on the thyroidal function in humans

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The nitrate-nitrite-nitric oxide pathway in physiology and therapeutics

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21 January 2018

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https://api.crossref.org/works/10.2903%2FJ.EFSA.2017.4787

Profound differences between humans and rodents in the ability to concentrate salivary nitrate: Implications for translational research.

21 January 2018

1 reference

https://api.crossref.org/works/10.2903%2FJ.EFSA.2017.4787

Cytogenetic study in cultured human lymphocytes treated with three commonly used preservatives

21 January 2018

1 reference

https://api.crossref.org/works/10.2903%2FJ.EFSA.2017.4787

The effect of dietary nitrate on salivary, plasma, and urinary nitrate metabolism in humans

21 January 2018

1 reference

https://api.crossref.org/works/10.2903%2FJ.EFSA.2017.4787

Possible effects of environmental nitrates and toxic organochlorines on human thyroid in highly polluted areas in Slovakia

21 January 2018

1 reference

https://api.crossref.org/works/10.2903%2FJ.EFSA.2017.4787

Journey of the iodide transporter NIS: from its molecular identification to its clinical role in cancer.

21 January 2018

1 reference

https://api.crossref.org/works/10.2903%2FJ.EFSA.2017.4787

Nitrate in public water supplies and the risk of colon and rectum cancers

21 January 2018

1 reference

https://api.crossref.org/works/10.2903%2FJ.EFSA.2017.4787

Quantitative relationship between oral nitrate-reducing activity and the endogenous formation of N-nitrosoamino acids in humans

21 January 2018

1 reference

https://api.crossref.org/works/10.2903%2FJ.EFSA.2017.4787

Human safety controversies surrounding nitrate and nitrite in the diet

21 January 2018

1 reference

https://api.crossref.org/works/10.2903%2FJ.EFSA.2017.4787

Meat and meat-related compounds and risk of prostate cancer in a large prospective cohort study in the United States

21 January 2018

1 reference

https://api.crossref.org/works/10.2903%2FJ.EFSA.2017.4787

Ion chromatographic method for the simultaneous determination of nitrite and nitrate by post-column indirect fluorescence detection

21 January 2018

1 reference

https://api.crossref.org/works/10.2903%2FJ.EFSA.2017.4787

The effects of perchlorate, nitrate, and thiocyanate on free thyroxine for potentially sensitive subpopulations of the 2001-2002 and 2007-2008 National Health and Nutrition Examination Surveys

21 January 2018

1 reference

https://api.crossref.org/works/10.2903%2FJ.EFSA.2017.4787

Increased thyroid volume and frequency of thyroid disorders signs in schoolchildren from nitrate polluted area

21 January 2018

1 reference

https://api.crossref.org/works/10.2903%2FJ.EFSA.2017.4787

Dynamics of nitrate and nitrite content during storage of home-made and small-scale industrially produced raw vegetable juices and their dietary intake.

21 January 2018

1 reference

https://api.crossref.org/works/10.2903%2FJ.EFSA.2017.4787

Intake and risk assessment of nitrate and nitrite from New Zealand foods and drinking water.

21 January 2018

1 reference

https://api.crossref.org/works/10.2903%2FJ.EFSA.2017.4787

Relative potencies and additivity of perchlorate, thiocyanate, nitrate, and iodide on the inhibition of radioactive iodide uptake by the human sodium iodide symporter.

21 January 2018

1 reference

https://api.crossref.org/works/10.2903%2FJ.EFSA.2017.4787

Review of the occurrence and formation of non-volatile N-nitroso compounds in foods

21 January 2018

1 reference

https://api.crossref.org/works/10.2903%2FJ.EFSA.2017.4787

High nitrate content in drinking water: cytogenetic effects in exposed children.

21 January 2018

1 reference

https://api.crossref.org/works/10.2903%2FJ.EFSA.2017.4787

Current perspectives and challenges in understanding the role of nitrite as an integral player in nitric oxide biology and therapy

21 January 2018

1 reference

https://api.crossref.org/works/10.2903%2FJ.EFSA.2017.4787

Influence of nitrate levels in drinking water on urological malignancies: a community-based cohort study.

21 January 2018

1 reference

https://api.crossref.org/works/10.2903%2FJ.EFSA.2017.4787

Reactions of nitrate and nitrite in foods with special reference to the determination of N-nitroso compounds

21 January 2018

1 reference

https://api.crossref.org/works/10.2903%2FJ.EFSA.2017.4787

Risk of non-Hodgkin lymphoma and nitrate and nitrite from drinking water and diet

21 January 2018

1 reference

https://api.crossref.org/works/10.2903%2FJ.EFSA.2017.4787

Processed meat intake, CYP2A6 activity and risk of colorectal adenoma.

21 January 2018

1 reference

https://api.crossref.org/works/10.2903%2FJ.EFSA.2017.4787

Nitrate in public water supplies and the risk of renal cell carcinoma.

21 January 2018

1 reference

https://api.crossref.org/works/10.2903%2FJ.EFSA.2017.4787

Adenocarcinoma of the stomach and esophagus and drinking water and dietary sources of nitrate and nitrite

21 January 2018

1 reference

https://api.crossref.org/works/10.2903%2FJ.EFSA.2017.4787

Nitrate intake and the risk of thyroid cancer and thyroid disease

21 January 2018

1 reference

https://api.crossref.org/works/10.2903%2FJ.EFSA.2017.4787

Acute blood pressure lowering, vasoprotective, and antiplatelet properties of dietary nitrate via bioconversion to nitrite

21 January 2018

1 reference

https://api.crossref.org/works/10.2903%2FJ.EFSA.2017.4787

Municipal drinking water nitrate level and cancer risk in older women: the Iowa Women's Health Study.

21 January 2018

1 reference

https://api.crossref.org/works/10.2903%2FJ.EFSA.2017.4787

A stepwise reduction in plasma and salivary nitrite with increasing strengths of mouthwash following a dietary nitrate load.

21 January 2018

1 reference

https://api.crossref.org/works/10.2903%2FJ.EFSA.2017.4787

Methemoglobinemia: etiology, pharmacology, and clinical management

21 January 2018

1 reference

https://api.crossref.org/works/10.2903%2FJ.EFSA.2017.4787

Plasma levels of nitrate and risk of prostate cancer: a prospective study

21 January 2018

1 reference

https://api.crossref.org/works/10.2903%2FJ.EFSA.2017.4787

Nitrate in drinking water and risk of death from colon cancer in Taiwan

21 January 2018

1 reference

https://api.crossref.org/works/10.2903%2FJ.EFSA.2017.4787

Nitrate in drinking water and risk of death from pancreatic cancer in Taiwan

21 January 2018

1 reference

https://api.crossref.org/works/10.2903%2FJ.EFSA.2017.4787

Dietary intake of nitrate relative to antioxidant vitamin in relation to breast cancer risk: a case-control study

21 January 2018

1 reference

https://api.crossref.org/works/10.2903%2FJ.EFSA.2017.4787

Impact of nitrate intake in drinking water on the thyroid gland activity in male rat.

21 January 2018

1 reference

https://api.crossref.org/works/10.2903%2FJ.EFSA.2017.4787

Nitrate intake does not influence bladder cancer risk: the Netherlands cohort study

21 January 2018

1 reference

https://api.crossref.org/works/10.2903%2FJ.EFSA.2017.4787

Risk assessment of N-nitrosodimethylamine formed endogenously after fish-with-vegetable meals

21 January 2018

1 reference

https://api.crossref.org/works/10.2903%2FJ.EFSA.2017.4787

A nested case-control study of methemoglobinemia risk factors in children of Transylvania, Romania

21 January 2018

1 reference

https://api.crossref.org/works/10.2903%2FJ.EFSA.2017.4787

Dietary N-nitroso compounds and risk of colorectal cancer: a case-control study in Newfoundland and Labrador and Ontario, Canada

21 January 2018

1 reference

https://api.crossref.org/works/10.2903%2FJ.EFSA.2017.4787

Kinetic Spectrophotometric Determination of Nitrite Based on Its Catalytic Effect on the Oxidation of Methyl Red by Bromate

21 January 2018

1 reference

https://api.crossref.org/works/10.2903%2FJ.EFSA.2017.4787

Evolution of nitrate and nitrite during the processing of dry-cured ham with partial replacement of NaCl by other chloride salts

21 January 2018

1 reference

https://api.crossref.org/works/10.2903%2FJ.EFSA.2017.4787

Distribution and metabolism of ingested NO3- and NO2- in germfree and conventional-flora rats

21 January 2018

1 reference

12 December 2020

Comparison of human adult and fetal hemoglobin: aminophenol-induced methemoglobin formation

1 reference

12 December 2020

Influence of dietary nitrate on nitrite content of human saliva: possible relevance to in vivo formation of N-nitroso compounds

1 reference

12 December 2020

Pharmacokinetic aspects of inorganic nitrate ingestion in man

1 reference

12 December 2020

[Environmental antithyroid chemicals]

1 reference

12 December 2020

In vivo genotoxicity of nitrates and nitrites in germ cells of male mice. I. Evidence for gonadal exposure and lack of heritable effects

1 reference

12 December 2020

In vivo genotoxicity of nitrates and nitrites in germ cells of male mice. II. Unscheduled DNA synthesis and sperm abnormality after treatment of spermatids

1 reference

12 December 2020

The reproducibility of the conversion of nitrate to nitrite in human saliva after a nitrate load

1 reference

12 December 2020

Growth impairment caused by dietary nitrate intake regulated via hypothyroidism and decreased somatomedin

1 reference

12 December 2020

Nitrate reduction, gastro-intestinal pH and N-nitrosation in gnotobiotic and conventional rats

1 reference

12 December 2020

Toxicological evaluation of certain food additives with a review of general principles and of specifications. Seventeenth report of the joint FAO-WHO Expert Committee on Food Additives

1 reference

12 December 2020

Erythrocyte DPNH dependent diaphorase levels in infants

1 reference

12 December 2020

Dose-Response Studies With Concurrent Administration of Piperazine and Sodium Nitrite to Strain A Mice2

1 reference

12 December 2020

Brief communication: feeding studies of nitrilotriacetic acid and derivatives in rats

1 reference

12 December 2020

The pharmacology of dietary nitrate and the origin of urinary nitrate

1 reference

12 December 2020

Metabolic fate of an oral dose of 15N-labeled nitrate in humans: effect of diet supplementation with ascorbic acid

1 reference

12 December 2020

Nitrate in human and canine milk

1 reference

12 December 2020

Carcinogenicity studies of sodium nitrite and sodium nitrate in F-344 rats

1 reference

12 December 2020

Effect of nitrate and nitrite in drinking water on rats

1 reference

12 December 2020

Chlorination of drinking water and cancer incidence.

1 reference

12 December 2020

Nitrate, nitrite and N-nitroso compounds.

1 reference

12 December 2020

Consumption of nitrate, nitrite, and nitrosodimethylamine and the risk of upper aerodigestive tract cancer.

1 reference

12 December 2020

Concentration of nitrates in drinking water and its relationship with bladder cancer

1 reference

12 December 2020

Consumption of drinking water with high nitrate levels causes hypertrophy of the thyroid

1 reference

12 December 2020

Metabolism and effect of nitrates

1 reference

12 December 2020

Geographic association between urinary excretion of N-nitroso compounds and oesophageal cancer mortality in China

1 reference

12 December 2020

Drinking water nitrate and the risk of non-Hodgkin's lymphoma

1 reference

12 December 2020

The distribution of leukaemia in association with domestic water quality in south west England

1 reference

12 December 2020

Analysis of human sodium iodide symporter gene expression in extrathyroidal tissues and cloning of its complementary deoxyribonucleic acids from salivary gland, mammary gland, and gastric mucosa

1 reference

12 December 2020

An immunohistochemical study of Na+/I- symporter in human thyroid tissues and salivary gland tissues

1 reference

12 December 2020

Analysis of human sodium iodide symporter immunoreactivity in human exocrine glands

1 reference

12 December 2020

A case-control study of nitrate in drinking water and non-Hodgkin's lymphoma in Minnesota

1 reference

12 December 2020

Na(+)/I(-) symporter and Pendred syndrome gene and protein expressions in human extra-thyroidal tissues

1 reference

12 December 2020

Evaluation of certain food additives and contaminants

1 reference

12 December 2020

Dietary nitrate generates potentially mutagenic concentrations of nitric oxide at the gastroesophageal junction

1 reference

12 December 2020

Testicular and spermatotoxic effect of nitrate in mice

1 reference

12 December 2020

An ecologic study of nitrate in municipal drinking water and cancer incidence in Trnava District, Slovakia

1 reference

12 December 2020

Nitrates/nitrites alter human lymphocyte proliferation and cytokine production

1 reference

12 December 2020

Deficient activity of DPNH-dependent methemoglobin diaphorase in cord blood erythrocytes

1 reference

12 December 2020

SPECIFICATIONS FOR THE IDENTITY AND PURITY OF FOOD ADDITIVES AND THEIR TOXICOLOGICAL EVALUATION: FOOD COLOURS AND SOME ANTIMICROBIALS AND ANTIOXIDANTS. EIGHTH REPORT OF THE JOINT FAO--WHO EXPERT COMMITTEE ON FOOD ADDITIVES

1 reference

12 December 2020

Changes in nitrate and nitrite content of four vegetables during storage at refrigerated and ambient temperatures

1 reference

12 December 2020

Development of a food database of nitrosamines, heterocyclic amines, and polycyclic aromatic hydrocarbons.

1 reference

12 December 2020

[Effects of inorganic nitrates on thyroid gland activity and morphology in female rats]

1 reference

12 December 2020

Food additive-induced chronic pruritus: further evidence

1 reference

12 December 2020

The emerging biology of the nitrite anion

1 reference

12 December 2020

Evaluation of possible goitrogenic and anti-thyroidal effect of nitrate, a potential environmental pollutant.

1 reference

12 December 2020

Ion chromatographic determination of nitrate and nitrite in vegetable and fruit baby foods.

1 reference

12 December 2020

Use of Griess reagent containing vanadium(III) for post-column derivatization and simultaneous determination of nitrite and nitrate in baby food.

1 reference

12 December 2020

Assessment of dietary exposure of nitrate and nitrite in France

1 reference

12 December 2020

The oral bioavailability of nitrate from nitrate-rich vegetables in humans

1 reference

12 December 2020

Simultaneous determination of nitrite and nitrate by normal phase ion-pair liquid chromatography

1 reference

12 December 2020

Impact of food processing and storage conditions on nitrate content in canned vegetable-based infant foods

1 reference

12 December 2020

Colon cancer and content of nitrates and magnesium in drinking water

1 reference

12 December 2020

Impact of cadaverine in volatile N-nitrosamine formation during the heating of a lean meat model.

1 reference

12 December 2020

IARC monographs on the evaluation of carcinogenic risks to humans. Ingested nitrate and nitrite, and cyanobacterial peptide toxins

1 reference

12 December 2020

Nitrates in Drinking Water and the Risk of Death from Childhood Brain Tumors in Taiwan

1 reference

12 December 2020

Genotoxicity testing of four food preservatives and their combinations in the Drosophila wing spot test

1 reference

12 December 2020

Absence of volatile N-nitrosamines in cooked nitrite-free cured muscle foods

1 reference

12 December 2020

Some observations on the absorption spectra of various myoglobin derivatives found in meat.

1 reference

12 December 2020

Cured colour development during sausage processing

1 reference

12 December 2020

Association of nitrogen compounds in drinking water with incidence of esophageal squamous cell carcinoma in Shexian, China

1 reference

12 December 2020

Nitrite and nitrate can be accurately measured in samples of vegetal and animal origin using an HPLC-UV/VIS technique

1 reference

12 December 2020

Magnesium in drinking water modifies the association between nitrate ingestion and risk of death from esophageal cancer

1 reference

12 December 2020

Sustaining elevated levels of nitrite in the oral cavity through consumption of nitrate-rich beetroot juice in young healthy adults reduces salivary pH

1 reference

12 December 2020

Identifiers

DOI

10.2903/J.EFSA.2017.4787

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:32625505%20AND%20SRC:MED&resulttype=core&format=json

8 July 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:32625505%20AND%20SRC:MED&resulttype=core&format=json

8 July 2020

1 reference