HCLK2 is required for activity of the DNA damage response kinase ATR. (Q45214462)

10 December 2017

HCLK2 is required for activity of the DNA damage response kinase ATR. (English)

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10 December 2017

7

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10 December 2017

6

Jiri Bartek

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10 December 2017

Dorthe Helena Larsen

2

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Raimundo Freire

object named as

Raimundo Freire

4

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author name string

Jannie M Rendtlew Danielsen

1

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10 December 2017

Kenneth Bødtker Schou

3

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10 December 2017

Jacob Falck

5

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10 December 2017

language of work or name

English

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publication date

19 December 2008

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Journal of Biological Chemistry

10 December 2017

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10 December 2017

284

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10 December 2017

7

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10 December 2017

4140-4147

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The DNA damage response: putting checkpoints in perspective

10 December 2017

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https://api.crossref.org/works/10.1074%2FJBC.M808174200

Spatial organization of the mammalian genome surveillance machinery in response to DNA strand breaks

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.M808174200

Cell-cycle checkpoints and cancer

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.M808174200

ATR-mediated checkpoint pathways regulate phosphorylation and activation of human Chk1

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.M808174200

Sensing DNA damage through ATRIP recognition of RPA-ssDNA complexes

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.M808174200

Claspin operates downstream of TopBP1 to direct ATR signaling towards Chk1 activation

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.M808174200

Identification and functional analysis of TopBP1 and its homologs

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.M808174200

Claspin and the activated form of ATR-ATRIP collaborate in the activation of Chk1.

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.M808174200

Conservation of the Chk1 checkpoint pathway in mammals: linkage of DNA damage to Cdk regulation through Cdc25

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M808174200

Determination of life-span in Caenorhabditis elegans by four clock genes

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M808174200

C. elegans RAD-5/CLK-2 defines a new DNA damage checkpoint protein

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.M808174200

Distinct modes of ATR activation after replication stress and DNA double-strand breaks in Caenorhabditis elegans

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.M808174200

HCLK2 is essential for the mammalian S-phase checkpoint and impacts on Chk1 stability

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M808174200

Tel2 mediates activation and localization of ATM/Tel1 kinase to a double-strand break.

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.M808174200

Tel2 regulates the stability of PI3K-related protein kinases

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M808174200

Rapamycin sensitivity of the Schizosaccharomyces pombe tor2 mutant and organization of two highly phosphorylated TOR complexes by specific and common subunits

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M808174200

Dynamic assembly and sustained retention of 53BP1 at the sites of DNA damage are controlled by Mdc1/NFBD1

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M808174200

The DNA damage-dependent intra-S phase checkpoint is regulated by parallel pathways

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.M808174200

Ataxia telangiectasia-mutated phosphorylates Chk2 in vivo and in vitro

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M808174200

Inhibition of Chk1 by CEP-3891 accelerates mitotic nuclear fragmentation in response to ionizing Radiation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M808174200

The PSIPRED protein structure prediction server

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.M808174200

TopBP1 activates the ATR-ATRIP complex

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M808174200

ATR and ATRIP: partners in checkpoint signaling

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M808174200

Activation of the ATM kinase by ionizing radiation and phosphorylation of p53

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M808174200

ATR is a caffeine-sensitive, DNA-activated protein kinase with a substrate specificity distinct from DNA-PK.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M808174200

TopBP1 activates ATR through ATRIP and a PIKK regulatory domain

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M808174200

Overexpression of a kinase-inactive ATR protein causes sensitivity to DNA-damaging agents and defects in cell cycle checkpoints

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M808174200

DNA damage activates ATM through intermolecular autophosphorylation and dimer dissociation

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M808174200

ATM activation by DNA double-strand breaks through the Mre11-Rad50-Nbs1 complex

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M808174200

Conserved modes of recruitment of ATM, ATR and DNA-PKcs to sites of DNA damage

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M808174200

Initiating cellular stress responses

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M808174200

Cell cycle checkpoint signaling through the ATM and ATR kinases

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M808174200

21 January 2018

Identifiers

DOI

10.1074/JBC.M808174200

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release_rnk5vxophbgrvez6pj2pko7tx4

10 December 2017

1 reference

Fatcat

https://api.fatcat.wiki/v0/release/rnk5vxophbgrvez6pj2pko7tx4

mapped directly with Wikidata item

24 November 2022

based on heuristic

1 reference