ATR is a caffeine-sensitive, DNA-activated protein kinase with a substrate specificity distinct from DNA-PK. (Q30585346)

25 June 2017

ATR is a caffeine-sensitive, DNA-activated protein kinase with a substrate specificity distinct from DNA-PK. (English)

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25 June 2017

C A Hall-Jackson

1

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25 June 2017

D A Cross

series ordinal

2

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25 June 2017

N Morrice

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3

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25 June 2017

C Smythe

series ordinal

4

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25 June 2017

language of work or name

English

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publication date

1 November 1999

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25 June 2017

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25 June 2017

18

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25 June 2017

6707-6713

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25 June 2017

48

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Identification and characterization of new elements involved in checkpoint and feedback controls in fission yeast

25 June 2017

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203077

Enhanced phosphorylation of p53 by ATM in response to DNA damage

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203077

A signaling pathway to translational control

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203077

Activation of the ATM kinase by ionizing radiation and phosphorylation of p53

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203077

A tightly associated serine/threonine protein kinase regulates phosphoinositide 3-kinase activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203077

Phosphatidylinositol 3-kinase activation is required for insulin stimulation of pp70 S6 kinase, DNA synthesis, and glucose transporter translocation

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203077

cDNA cloning and gene mapping of a candidate human cell cycle checkpoint protein

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203077

Overexpression of a kinase-inactive ATR protein causes sensitivity to DNA-damaging agents and defects in cell cycle checkpoints

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203077

PD 98059 prevents establishment of the spindle assembly checkpoint and inhibits the G2-M transition in meiotic but not mitotic cell cycles in Xenopus.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203077

A topoisomerase II-dependent G2 cycle checkpoint in mammalian cells/.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203077

Cdc25 Mitotic Inducer Targeted by Chk1 DNA Damage Checkpoint Kinase

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203077

Characterization of ATM expression, localization, and associated DNA-dependent protein kinase activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203077

TEL1, a gene involved in controlling telomere length in S. cerevisiae, is homologous to the human ataxia telangiectasia gene.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203077

The TOR signalling pathway and growth control in yeast

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203077

DNA-dependent protein kinase: DNA binding and activation in the absence of Ku

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203077

The mei-41 gene of D. melanogaster is a structural and functional homolog of the human ataxia telangiectasia gene

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203077

DNA-dependent protein kinase catalytic subunit: a relative of phosphatidylinositol 3-kinase and the ataxia telangiectasia gene product

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203077

Cell cycle control and cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203077

Responses to DNA damage and regulation of cell cycle checkpoints by the ATM protein kinase family

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203077

When is a lipid kinase not a lipid kinase? When it is a protein kinase

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203077

Regulation of the specific DNA binding function of p53

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203077

DNA double-strand break repair and V(D)J recombination: involvement of DNA-PK.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203077

The Atr and Atm protein kinases associate with different sites along meiotically pairing chromosomes.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203077

Lessons from hereditary colorectal cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203077

Human DNA-activated protein kinase phosphorylates serines 15 and 37 in the amino-terminal transactivation domain of human p53.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203077

The ionizing radiation-induced replication protein A phosphorylation response differs between ataxia telangiectasia and normal human cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203077

Nuclear localization of Cdc25 is regulated by DNA damage and a 14-3-3 protein

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203077

Analysis of Rad3 and Chk1 protein kinases defines different checkpoint responses.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203077

Premature of chromosome condensation in a ts DNA- mutant of BHK cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203077

Mitotic and G2 checkpoint control: regulation of 14-3-3 protein binding by phosphorylation of Cdc25C on serine-216

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203077

Conservation of the Chk1 checkpoint pathway in mammals: linkage of DNA damage to Cdk regulation through Cdc25

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203077

The complete sequence of the coding region of the ATM gene reveals similarity to cell cycle regulators in different species

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203077

Phosphatidylinositol 3-kinase encoded by yeast VPS34 gene essential for protein sorting

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203077

DNA damage-induced phosphorylation of p53 alleviates inhibition by MDM2

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203077

Coupling of mitosis to the completion of S phase in Xenopus occurs via modulation of the tyrosine kinase that phosphorylates p34cdc2.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203077

A role for ATR in the DNA damage-induced phosphorylation of p53

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203077

The RAD9 gene controls the cell cycle response to DNA damage in Saccharomyces cerevisiae

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203077

DNA-dependent protein kinase acts upstream of p53 in response to DNA damage

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203077

Protein kinase mutants of human ATR increase sensitivity to UV and ionizing radiation and abrogate cell cycle checkpoint control

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203077

Role of SAPK/ERK kinase-1 in the stress-activated pathway regulating transcription factor c-Jun

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203077

Replication checkpoint requires phosphorylation of the phosphatase Cdc25 by Cds1 or Chk1

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203077

The Schizosaccharomyces pombe rad3 checkpoint gene

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203077

7 January 2021

Direct inhibition of the signaling functions of the mammalian target of rapamycin by the phosphoinositide 3-kinase inhibitors, wortmannin and LY294002.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203077

7 January 2021

Staurosporine- and radiation-induced G2-phase cell cycle blocks are equally released by caffeine

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203077

7 January 2021

PI 3-kinase is a dual specificity enzyme: autoregulation by an intrinsic protein-serine kinase activity.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203077

7 January 2021

TEL1, an S. cerevisiae homolog of the human gene mutated in ataxia telangiectasia, is functionally related to the yeast checkpoint gene MEC1

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203077

7 January 2021

Differential effects of caffeine on DNA damage and replication cell cycle checkpoints in the fission yeast Schizosaccharomyces pombe

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203077

7 January 2021

Caffeine-induced uncoupling of mitosis from the completion of DNA replication in mammalian cells

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203077

7 January 2021

A novel mutation avoidance mechanism dependent on S. cerevisiae RAD27 is distinct from DNA mismatch repair

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203077

7 January 2021

Identifiers

DOI

10.1038/SJ.ONC.1203077

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Dimensions Publication ID

25 June 2017

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1 reference