The relationship between Abeta and memory in the Tg2576 mouse model of Alzheimer's disease. (Q33292445)

25 July 2017

The relationship between Abeta and memory in the Tg2576 mouse model of Alzheimer's disease (English)

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12 May 2020

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GOA release 2020-03-11

Amyloid beta precursor protein

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positive regulation of amyloid fibril formation

GOA release 2020-03-11

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GOA release 2020-03-11

9

Karen H Ashe

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12 May 2020

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Steven G Younkin

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12 May 2020

6

Linda H Younkin

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12 May 2020

7

George A Carlson

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12 May 2020

author name string

Marcus A Westerman

1

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12 May 2020

Deirdre Cooper-Blacketer

2

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12 May 2020

Ami Mariash

3

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12 May 2020

Linda Kotilinek

4

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12 May 2020

Takeshi Kawarabayashi

5

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12 May 2020

language of work or name

English

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publication date

1 March 2002

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25 July 2017

Journal of Neuroscience

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12 May 2020

volume

22

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12 May 2020

page(s)

1858-1867

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12 May 2020

issue

5

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Physical basis of cognitive alterations in alzheimer's disease: Synapse loss is the major correlate of cognitive impairment

12 May 2020

cites work

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12 December 2020

High-level neuronal expression of abeta 1-42 in wild-type human amyloid protein precursor transgenic mice: synaptotoxicity without plaque formation

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12 December 2020

Purification and cloning of amyloid precursor protein beta-secretase from human brain

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12 December 2020

Diffusible, nonfibrillar ligands derived from Abeta1-42 are potent central nervous system neurotoxins

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12 December 2020

Amyloid beta protein (A beta) in Alzheimer's disease brain. Biochemical and immunocytochemical analysis with antibodies specific for forms ending at A beta 40 or A beta 42(43).

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12 December 2020

Behavioral changes in transgenic mice expressing both amyloid precursor protein and presenilin-1 mutations: lack of association with amyloid deposits.

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12 December 2020

Beta-secretase cleavage of Alzheimer's amyloid precursor protein by the transmembrane aspartic protease BACE

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12 December 2020

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12 December 2020

An increased percentage of long amyloid beta protein secreted by familial amyloid beta protein precursor (beta APP717) mutants.

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12 December 2020

Amyloid precursor protein processing and A beta42 deposition in a transgenic mouse model of Alzheimer disease

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12 December 2020

Developments of a water-maze procedure for studying spatial learning in the rat

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12 December 2020

Clinical, pathological, and neurochemical changes in dementia: A subgroup with preserved mental status and numerous neocortical plaques

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12 December 2020

Increased amyloid-beta42(43) in brains of mice expressing mutant presenilin 1

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12 December 2020

Beta-amyloid deposition and other measures of neuropathology predict cognitive status in Alzheimer's disease.

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12 December 2020

Accelerated Alzheimer-type phenotype in transgenic mice carrying both mutant amyloid precursor protein and presenilin 1 transgenes

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12 December 2020

A beta peptide vaccination prevents memory loss in an animal model of Alzheimer's disease.

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12 December 2020

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12 December 2020

Chimeric prion protein expression in cultured cells and transgenic mice

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12 December 2020

The levels of soluble versus insoluble brain Abeta distinguish Alzheimer's disease from normal and pathologic aging.

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12 December 2020

Progressive and gender-dependent cognitive impairment in the APP(SW) transgenic mouse model for Alzheimer's disease.

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12 December 2020

APPSw transgenic mice develop age-related A beta deposits and neuropil abnormalities, but no neuronal loss in CA1.

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12 December 2020

Correlation between elevated levels of amyloid beta-peptide in the brain and cognitive decline

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12 December 2020

A learning deficit related to age and beta-amyloid plaques in a mouse model of Alzheimer's disease

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12 December 2020

Severity of spatial learning impairment in aging: development of a learning index for performance in the Morris water maze.

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12 December 2020

Mutant presenilins of Alzheimer's disease increase production of 42-residue amyloid beta-protein in both transfected cells and transgenic mice

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12 December 2020

Adaptation of the circular platform spatial memory task for mice: use in detecting cognitive impairment in the APP(SW) transgenic mouse model for Alzheimer's disease.

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12 December 2020

Memory-enhancing effects of secreted forms of the beta-amyloid precursor protein in normal and amnestic mice.

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12 December 2020

The mean A beta load in the hippocampus correlates with duration and severity of dementia in subgroups of Alzheimer disease.

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12 December 2020

Protofibrillar intermediates of amyloid beta-protein induce acute electrophysiological changes and progressive neurotoxicity in cortical neurons.

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12 December 2020

Alzheimer's disease: genes, proteins, and therapy

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12 December 2020

Identification of normal and pathological aging in prospectively studied nondemented elderly humans

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12 December 2020

Plaque-independent disruption of neural circuits in Alzheimer's disease mouse models

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12 December 2020

Caloric restriction and spatial learning in old mice.

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12 December 2020

Release of excess amyloid beta protein from a mutant amyloid beta protein precursor.

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12 December 2020

Correlative Memory Deficits, Abeta Elevation, and Amyloid Plaques in Transgenic Mice

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12 December 2020

Correlation between cognitive deficits and Abeta deposits in transgenic APP+PS1 mice.

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12 December 2020

Neurofibrillary tangles but not senile plaques parallel duration and severity of Alzheimer's disease

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12 December 2020

Early-onset amyloid deposition and cognitive deficits in transgenic mice expressing a double mutant form of amyloid precursor protein 695.

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12 December 2020

Neuropathological indexes of Alzheimer's disease in demented and nondemented persons aged 80 years and older.

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12 December 2020

Biochemical detection of Abeta isoforms: implications for pathogenesis, diagnosis, and treatment of Alzheimer's disease

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12 December 2020

Amyloid deposition as the central event in the aetiology of Alzheimer's disease

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12 December 2020

Morphology and toxicity of Abeta-(1-42) dimer derived from neuritic and vascular amyloid deposits of Alzheimer's disease.

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12 December 2020

Age-dependent changes in brain, CSF, and plasma amyloid (beta) protein in the Tg2576 transgenic mouse model of Alzheimer's disease.

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12 December 2020

Alzheimer-type neuropathology in transgenic mice overexpressing V717F β-amyloid precursor protein

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12 December 2020

Large amounts of neocortical beta A4 deposits without neuritic plaques nor tangles in a psychometrically assessed, non-demented person

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12 December 2020

Effects of aging on spatial learning and hippocampal protein kinase C in mice.

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12 December 2020

Formation of beta-amyloid protein deposits in brains of transgenic mice

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12 December 2020

Increase of synaptic density and memory retention by a peptide representing the trophic domain of the amyloid beta/A4 protein precursor

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12 December 2020

Impaired synaptic plasticity and learning in aged amyloid precursor protein transgenic mice.

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12 December 2020

10.1523/JNEUROSCI.22-05-01858.2002

Identifiers

DOI

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6758862&resulttype=core&format=json

12 May 2020

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6758862&resulttype=core&format=json

12 May 2020

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