Modulation of insulin-stimulated degradation of human insulin receptor substrate-1 by Serine 312 phosphorylation (Q44268162)

1 December 2017

Modulation of insulin-stimulated degradation of human insulin receptor substrate-1 by Serine 312 phosphorylation (English)

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1 December 2017

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4

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1 December 2017

Michael W Greene

1

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author name string

Hiroshi Sakaue

series ordinal

2

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1 December 2017

Lihong Wang

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3

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1 December 2017

Richard A Roth

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5

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1 December 2017

language of work or name

English

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publication date

1 January 2003

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Journal of Biological Chemistry

1 December 2017

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1 December 2017

278

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1 December 2017

8199-8211

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1 December 2017

10

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A novel 160-kDa phosphotyrosine protein in insulin-treated embryonic kidney cells is a new member of the insulin receptor substrate family

1 December 2017

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The 60-kDa phosphotyrosine protein in insulin-treated adipocytes is a new member of the insulin receptor substrate family.

21 January 2018

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Structure of the insulin receptor substrate IRS-1 defines a unique signal transduction protein

21 January 2018

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Role of IRS-2 in insulin and cytokine signalling

21 January 2018

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Role of binding proteins to IRS-1 in insulin signalling.

21 January 2018

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The IRS-signalling system: a network of docking proteins that mediate insulin action

21 January 2018

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Mechanism of activation and function of protein kinase B.

21 January 2018

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Insulin resistance and a diabetes mellitus-like syndrome in mice lacking the protein kinase Akt2 (PKB beta)

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Expression of a constitutively active Akt Ser/Thr kinase in 3T3-L1 adipocytes stimulates glucose uptake and glucose transporter 4 translocation

21 January 2018

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Construction and characterization of a conditionally active version of the serine/threonine kinase Akt.

21 January 2018

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Protein kinase B/Akt participates in GLUT4 translocation by insulin in L6 myoblasts

21 January 2018

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The role of glycogen synthase kinase 3beta in insulin-stimulated glucose metabolism

21 January 2018

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Insulin-induced phosphorylation and activation of cyclic nucleotide phosphodiesterase 3B by the serine-threonine kinase Akt

21 January 2018

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Protein kinase B/Akt induces resumption of meiosis in Xenopus oocytes.

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Interplay between insulin and nutrients in the regulation of translation factors

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Evidence of insulin-stimulated phosphorylation and activation of the mammalian target of rapamycin mediated by a protein kinase B signaling pathway

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CAP defines a second signalling pathway required for insulin-stimulated glucose transport

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Turning down insulin signaling.

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Virtual cloning, functional expression, and gating analysis of human connexin31.9.

21 January 2018

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IRS-1-mediated inhibition of insulin receptor tyrosine kinase activity in TNF-alpha- and obesity-induced insulin resistance

21 January 2018

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Modulation of insulin receptor substrate-1 tyrosine phosphorylation by an Akt/phosphatidylinositol 3-kinase pathway

21 January 2018

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Phosphorylation of insulin receptor substrate-1 on multiple serine residues, 612, 632, 662, and 731, modulates insulin action

21 January 2018

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A molecular basis for insulin resistance. Elevated serine/threonine phosphorylation of IRS-1 and IRS-2 inhibits their binding to the juxtamembrane region of the insulin receptor and impairs their ability to undergo insulin-induced tyrosine phosphory

21 January 2018

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Insulin receptor substrate 1 is phosphorylated by the serine kinase activity of phosphatidylinositol 3-kinase

21 January 2018

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Modulation of insulin receptor substrate-1 tyrosine phosphorylation and function by mitogen-activated protein kinase

21 January 2018

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Protein kinase C modulation of insulin receptor substrate-1 tyrosine phosphorylation requires serine 612.

21 January 2018

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The c-Jun NH(2)-terminal kinase promotes insulin resistance during association with insulin receptor substrate-1 and phosphorylation of Ser(307)

21 January 2018

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A phosphatidylinositol 3-kinase/Akt/mTOR pathway mediates and PTEN antagonizes tumor necrosis factor inhibition of insulin signaling through insulin receptor substrate-1.

21 January 2018

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In vivo phosphorylation of insulin receptor substrate 1 at serine 789 by a novel serine kinase in insulin-resistant rodents

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Intracellular localization of phosphatidylinositide 3-kinase and insulin receptor substrate-1 in adipocytes: potential involvement of a membrane skeleton

21 January 2018

1 reference

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Release of insulin receptor substrate proteins from an intracellular complex coincides with the development of insulin resistance.

21 January 2018

1 reference

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Insulin stimulates the degradation of IRS-1 in 3T3-L1 adipocytes

21 January 2018

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Rapamycin partially prevents insulin resistance induced by chronic insulin treatment

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Serine/threonine phosphorylation of IRS-1 triggers its degradation: possible regulation by tyrosine phosphorylation

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Role of mTOR in the degradation of IRS-1: regulation of PP2A activity

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Regulation of insulin/insulin-like growth factor-1 signaling by proteasome-mediated degradation of insulin receptor substrate-2.

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Mammalian target of rapamycin pathway regulates insulin signaling via subcellular redistribution of insulin receptor substrate 1 and integrates nutritional signals and metabolic signals of insulin

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Molecular mechanism of insulin-induced degradation of insulin receptor substrate 1

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Insulin receptor substrate (IRS) 1 is reduced and IRS-2 is the main docking protein for phosphatidylinositol 3-kinase in adipocytes from subjects with non-insulin-dependent diabetes mellitus

21 January 2018

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Wortmannin and LY294002 inhibit the insulin-induced down-regulation of IRS-1 in 3T3-L1 adipocytes

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Persistent activation of phosphatidylinositol 3-kinase causes insulin resistance due to accelerated insulin-induced insulin receptor substrate-1 degradation in 3T3-L1 adipocytes

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Insulin-like growth factor I-induced degradation of insulin receptor substrate 1 is mediated by the 26S proteasome and blocked by phosphatidylinositol 3'-kinase inhibition

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Positive and negative regulatory role of insulin receptor substrate 1 and 2 (IRS-1 and IRS-2) serine/threonine phosphorylation.

21 January 2018

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3-Phosphoinositide-dependent protein kinase-1 (PDK1): structural and functional homology with the Drosophila DSTPK61 kinase

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Production of high-titer helper-free retroviruses by transient transfection

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Further evidence that 3-phosphoinositide-dependent protein kinase-1 (PDK1) is required for the stability and phosphorylation of protein kinase C (PKC) isoforms.

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The role of 3-phosphoinositide-dependent protein kinase 1 in activating AGC kinases defined in embryonic stem cells

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Insulin-induced insulin receptor substrate-1 degradation is mediated by the proteasome degradation pathway.

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Characterization of a 3-phosphoinositide-dependent protein kinase which phosphorylates and activates protein kinase Balpha

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Dual role of phosphatidylinositol-3,4,5-trisphosphate in the activation of protein kinase B

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SP600125, an anthrapyrazolone inhibitor of Jun N-terminal kinase

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Recent advances in our understanding of insulin action and insulin resistance

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Phosphorylation of Ser307 in insulin receptor substrate-1 blocks interactions with the insulin receptor and inhibits insulin action

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c-Jun N-terminal kinase (JNK) mediates feedback inhibition of the insulin signaling cascade

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Mechanism by which fatty acids inhibit insulin activation of insulin receptor substrate-1 (IRS-1)-associated phosphatidylinositol 3-kinase activity in muscle

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Salicylic acid reverses phorbol 12-myristate-13-acetate (PMA)- and tumor necrosis factor alpha (TNFalpha)-induced insulin receptor substrate 1 (IRS1) serine 307 phosphorylation and insulin resistance in human embryonic kidney 293 (HEK293) cells

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Serine phosphorylation of insulin receptor substrate 1 by inhibitor kappa B kinase complex.

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Protein phosphatase 2A interacts with the 70-kDa S6 kinase and is activated by inhibition of FKBP12-rapamycinassociated protein

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21 January 2018

Identifiers

DOI

10.1074/JBC.M209153200

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1 December 2017

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