preproinsulin (Q7240673)

http://www.ebi.ac.uk/interpro/protein/C9JNR5

Insulin-like superfamily

2 references

http://www.ebi.ac.uk/interpro/protein/C9JNR5

Insulin-like domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

Insulin, conserved site, protein family

1 reference

based on heuristic

inferred from protein domain or family

1 reference

18 December 2019

1 reference

18 December 2019

insulin receptor binding

Purified hybrid insulin/insulin-like growth factor-I receptors bind insulin-like growth factor-I, but not insulin, with high affinity

3 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01308

8 April 2019

Binding of human, porcine and bovine insulin to insulin receptors from human brain, muscle and adipocytes and to expressed recombinant alternatively spliced insulin receptor isoforms

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01308

8 April 2019

Familial hyperproinsulinaemia due to a mutation substituting histidine for arginine at position 65 in proinsulin: identification of the mutation by restriction enzyme mapping

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01308

identical protein binding

5 references

8 April 2019

A helical structural nucleus is the primary elongating unit of insulin amyloid fibrils

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01308

8 April 2019

Structural features of proinsulin C-peptide oligomeric and amyloid states

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01308

8 April 2019

Insulin solubility transitions by pH-dependent interactions with proinsulin C-peptide

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01308

8 April 2019

Peptides that form β‐sheets on hydrophobic surfaces accelerate surface‐induced insulin amyloidal aggregation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01308

8 April 2019

Amino acid sequence determinants in self‐assembly of insulin chiral amyloid superstructures: Role of C‐terminus of B‐chain in association of fibrils

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01308

protease binding

1 reference

8 April 2019

In vitro degradation of insulin-like peptide 3 by insulin-degrading enzyme

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01308

insulin-like growth factor receptor binding

1 reference

8 April 2019

Purified hybrid insulin/insulin-like growth factor-I receptors bind insulin-like growth factor-I, but not insulin, with high affinity

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01308

protein binding

4 references

8 April 2019

Megalin is an endocytic receptor for insulin

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01308

8 April 2019

Structures of human insulin-degrading enzyme reveal a new substrate recognition mechanism

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01308

8 April 2019

How insulin engages its primary binding site on the insulin receptor

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01308

8 April 2019

Inhibition of Insulin Receptor Activation by Insulin-like Growth Factor Binding Proteins

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01308

hormone activity

Impaired binding of insulin to erythrocyte membrane receptor and the activation of nitric oxide synthase by the hormone in human breast cancer

5 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01308

8 April 2019

A structurally abnormal insulin causing human diabetes

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01308

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01308

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01308

8 April 2019

IEA

8 April 2019

Familial hyperproinsulinaemia due to a mutation substituting histidine for arginine at position 65 in proinsulin: identification of the mutation by restriction enzyme mapping

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01308

insulin-like growth factor receptor binding

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:C9JNR5

1 reference

9 May 2019

endoplasmic reticulum lumen

cell component

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01308

1 reference

8 April 2019

transport vesicle

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01308

1 reference

8 April 2019

Golgi membrane

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01308

1 reference

8 April 2019

secretory granule lumen

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01308

1 reference

8 April 2019

Golgi lumen

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01308

1 reference

8 April 2019

endoplasmic reticulum-Golgi intermediate compartment membrane

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01308

1 reference

8 April 2019

endosome lumen

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01308

1 reference

8 April 2019

extracellular region

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01308

4 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01308

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01308

8 April 2019

IEA

8 April 2019

Binding of human, porcine and bovine insulin to insulin receptors from human brain, muscle and adipocytes and to expressed recombinant alternatively spliced insulin receptor isoforms

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01308

extracellular space

1 reference

8 April 2019

Familial hyperproinsulinaemia due to a mutation substituting histidine for arginine at position 65 in proinsulin: identification of the mutation by restriction enzyme mapping

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01308

extracellular space

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:C9JNR5

1 reference

9 May 2019

negative regulation of NAD(P)H oxidase activity

biological process

1 reference

8 April 2019

Insulin inhibits intranuclear nuclear factor kappaB and stimulates IkappaB in mononuclear cells in obese subjects: evidence for an anti-inflammatory effect?

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01308

positive regulation of DNA replication

1 reference

9 May 2017

Insulin and IGF-1 increase mitogenesis and glucose metabolism in the multiple myeloma cell line, RPMI 8226

http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=P01308

positive regulation of MAPK cascade

2 references

8 April 2019

A novel domain of caveolin-2 that controls nuclear targeting: regulation of insulin-specific ERK activation and nuclear translocation by caveolin-2

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01308

8 April 2019

Regulation of the Akt/Glycogen synthase kinase-3 axis by insulin-like growth factor-II via activation of the human insulin receptor isoform-A

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01308

positive regulation of brown fat cell differentiation

1 reference

8 April 2019

Insulin and glucocorticoids differentially regulate leptin transcription and secretion in brown adipocytes

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01308

positive regulation of cell differentiation

1 reference

8 April 2019

Insulin signalling and the regulation of glucose and lipid metabolism

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01308

MAPK cascade

1 reference

9 May 2017

Insulin stimulates PKCzeta -mediated phosphorylation of insulin receptor substrate-1 (IRS-1). A self-attenuated mechanism to negatively regulate the function of IRS proteins

http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=P01308

positive regulation of respiratory burst

1 reference

8 April 2019

Insulin-induced activation of NADPH-dependent H2O2 generation in human adipocyte plasma membranes is mediated by Galphai2

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01308

positive regulation of phosphatidylinositol 3-kinase signaling

1 reference

8 April 2019

Insulin and IGF-1 increase mitogenesis and glucose metabolism in the multiple myeloma cell line, RPMI 8226

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01308

negative regulation of protein oligomerization

1 reference

8 April 2019

Insulin-degrading enzyme regulates extracellular levels of amyloid beta-protein by degradation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01308

positive regulation of NF-kappaB transcription factor activity

1 reference

8 April 2019

Extracellular PBEF/NAMPT/visfatin activates pro-inflammatory signalling in human vascular smooth muscle cells through nicotinamide phosphoribosyltransferase activity

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01308

negative regulation of respiratory burst involved in inflammatory response

1 reference

8 April 2019

Insulin inhibits intranuclear nuclear factor kappaB and stimulates IkappaB in mononuclear cells in obese subjects: evidence for an anti-inflammatory effect?

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01308

cell-cell signaling

1 reference

8 April 2019

Binding of human, porcine and bovine insulin to insulin receptors from human brain, muscle and adipocytes and to expressed recombinant alternatively spliced insulin receptor isoforms

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01308

positive regulation of nitric oxide biosynthetic process

1 reference

9 May 2017

Insulin stimulates glucose transport via nitric oxide/cyclic GMP pathway in human vascular smooth muscle cells

http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=P01308

positive regulation of nitric-oxide synthase activity

1 reference

8 April 2019

Insulin-dependent activation of endothelial nitric oxide synthase is impaired by O-linked glycosylation modification of signaling proteins in human coronary endothelial cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01308

positive regulation of protein autophosphorylation

1 reference

8 April 2019

Replacement of insulin receptor tyrosine residues 1162 and 1163 compromises insulin-stimulated kinase activity and uptake of 2-deoxyglucose

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01308

activation of protein kinase B activity

1 reference

8 April 2019

Akt, a pleckstrin homology domain containing kinase, is activated primarily by phosphorylation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01308

wound healing

1 reference

8 April 2019

Effects of Insulin on Wound Healing

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01308

positive regulation of mitotic nuclear division

negative regulation of feeding behavior

1 reference

8 April 2019

Milk intake and feeding behavior in the first week of life and its relationship to cord blood ghrelin, leptin, and insulin concentrations

Developmental FunctionaL Annotation at Tufts

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01308

positive regulation of peptide hormone secretion

1 reference

8 April 2019

Insulin and glucocorticoids differentially regulate leptin transcription and secretion in brown adipocytes

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01308

negative regulation of protein catabolic process

1 reference

8 April 2019

Intravenous insulin decreases protein breakdown in infants on extracorporeal membrane oxygenation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01308

positive regulation of cell migration

1 reference

8 April 2019

Insulin/insulin-like growth factor I hybrid receptors have different biological characteristics depending on the insulin receptor isoform involved

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01308

acute-phase response

1 reference

8 April 2019

Insulin decreases hepatic acute phase protein levels in severely burned children

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01308

regulation of protein secretion

1 reference

8 April 2019

Insulin decreases the secretion of apoB-100 from hepatic HepG2 cells but does not decrease the secretion of apoB-48 from intestinal CaCo-2 cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01308

positive regulation of glycogen biosynthetic process

1 reference

8 April 2019

Activation of the insulin receptor by insulin and a synthetic peptide leads to divergent metabolic and mitogenic signaling and responses

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01308

positive regulation of protein kinase B signaling

1 reference

8 April 2019

Regulation of the Akt/Glycogen synthase kinase-3 axis by insulin-like growth factor-II via activation of the human insulin receptor isoform-A

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01308

G protein-coupled receptor signaling pathway

1 reference

8 April 2019

Insulin-induced activation of NADPH-dependent H2O2 generation in human adipocyte plasma membranes is mediated by Galphai2

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01308

regulation of cellular amino acid metabolic process

1 reference

8 April 2019

Effect of intravenous insulin treatment on in vivo whole body leucine kinetics and oxygen consumption in insulin-deprived type I diabetic patients

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01308

negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway

1 reference

8 April 2019

Neuroprotection of insulin against oxidative stress-induced apoptosis in cultured retinal neurons: involvement of phosphoinositide 3-kinase/Akt signal pathway

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01308

endoplasmic reticulum to Golgi vesicle-mediated transport

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01308

1 reference

8 April 2019

positive regulation of cell growth

1 reference

8 April 2019

Insulin signalling and the regulation of glucose and lipid metabolism

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01308

negative regulation of glycogen catabolic process

1 reference

8 April 2019

A structurally abnormal insulin causing human diabetes

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01308

positive regulation of insulin receptor signaling pathway

1 reference

9 May 2017

Insulin and IGF-1 increase mitogenesis and glucose metabolism in the multiple myeloma cell line, RPMI 8226

http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=P01308

negative regulation of acute inflammatory response

1 reference

8 April 2019

Insulin inhibits intranuclear nuclear factor kappaB and stimulates IkappaB in mononuclear cells in obese subjects: evidence for an anti-inflammatory effect?

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01308

negative regulation of protein secretion

1 reference

8 April 2019

Insulin decreases hepatic acute phase protein levels in severely burned children

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01308

positive regulation of peptidyl-tyrosine phosphorylation

1 reference

9 May 2017

Insulin stimulates PKCzeta -mediated phosphorylation of insulin receptor substrate-1 (IRS-1). A self-attenuated mechanism to negatively regulate the function of IRS proteins

http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=P01308

glucose homeostasis

1 reference

8 April 2019

A structurally abnormal insulin causing human diabetes

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01308

positive regulation of cell population proliferation

fatty acid homeostasis

1 reference

8 April 2019

Glucagon regulation of plasma ketone body concentration in human diabetes

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01308

positive regulation of protein metabolic process

1 reference

8 April 2019

Effect of intravenous insulin treatment on in vivo whole body leucine kinetics and oxygen consumption in insulin-deprived type I diabetic patients

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01308

regulation of transmembrane transporter activity

1 reference

8 April 2019

Insulin stimulates glucose transport via nitric oxide/cyclic GMP pathway in human vascular smooth muscle cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01308

negative regulation of gluconeogenesis

1 reference

8 April 2019

Insulin signalling and the regulation of glucose and lipid metabolism

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01308

negative regulation of fatty acid metabolic process

1 reference

8 April 2019

Glucagon regulation of plasma ketone body concentration in human diabetes

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01308

regulation of protein localization

1 reference

8 April 2019

Insulin stimulates glucose transport via nitric oxide/cyclic GMP pathway in human vascular smooth muscle cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01308

regulation of transcription, DNA-templated

1 reference

8 April 2019

Differential gene expression induced by insulin and insulin-like growth factor-II through the insulin receptor isoform A

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01308

positive regulation of lipid biosynthetic process

1 reference

8 April 2019

Insulin signalling and the regulation of glucose and lipid metabolism

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01308

negative regulation of proteolysis

1 reference

8 April 2019

Effect of intravenous insulin treatment on in vivo whole body leucine kinetics and oxygen consumption in insulin-deprived type I diabetic patients

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01308

alpha-beta T cell activation

1 reference

8 April 2019

Bovine and human insulin activate CD8+-autoreactive CTL expressing both type 1 and type 2 cytokines in C57BL/6 mice

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01308

positive regulation of protein localization to nucleus

1 reference

8 April 2019

A novel domain of caveolin-2 that controls nuclear targeting: regulation of insulin-specific ERK activation and nuclear translocation by caveolin-2

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01308

positive regulation of glucose import

1 reference

9 May 2017

Insulin stimulates glucose transport via nitric oxide/cyclic GMP pathway in human vascular smooth muscle cells

http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=P01308

positive regulation of gene expression

1 reference

8 April 2019

Glucose tolerance is associated with differential expression of microRNAs in skeletal muscle: results from studies of twins with and without type 2 diabetes

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01308

positive regulation of nitric oxide mediated signal transduction

positive regulation of glucose import

Insulin stimulates glucose transport via nitric oxide/cyclic GMP pathway in human vascular smooth muscle cells

3 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01308

8 April 2019

Insulin and nitric oxide stimulates glucose transport in human placenta

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01308

8 April 2019

Insulin stimulates glucose transport via nitric oxide/cyclic GMP pathway in human vascular smooth muscle cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01308

positive regulation of insulin receptor signaling pathway

Insulin stimulates glucose transport via nitric oxide/cyclic GMP pathway in human vascular smooth muscle cells

3 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01308

8 April 2019

Insulin and nitric oxide stimulates glucose transport in human placenta

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01308

8 April 2019

Insulin and IGF-1 increase mitogenesis and glucose metabolism in the multiple myeloma cell line, RPMI 8226

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01308

regulation of synaptic plasticity

1 reference

8 April 2019

Protection of synapses against Alzheimer's-linked toxins: insulin signaling prevents the pathogenic binding of Abeta oligomers

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01308

cognition

1 reference

8 April 2019

Protection of synapses against Alzheimer's-linked toxins: insulin signaling prevents the pathogenic binding of Abeta oligomers

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01308

positive regulation of long-term synaptic potentiation

1 reference

8 April 2019

Protection of synapses against Alzheimer's-linked toxins: insulin signaling prevents the pathogenic binding of Abeta oligomers

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01308

positive regulation of dendritic spine maintenance

1 reference

8 April 2019

Protection of synapses against Alzheimer's-linked toxins: insulin signaling prevents the pathogenic binding of Abeta oligomers

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01308

regulation of protein localization to plasma membrane

1 reference

8 April 2019

Protection of synapses against Alzheimer's-linked toxins: insulin signaling prevents the pathogenic binding of Abeta oligomers

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01308

negative regulation of reactive oxygen species biosynthetic process

1 reference

8 April 2019

Protection of synapses against Alzheimer's-linked toxins: insulin signaling prevents the pathogenic binding of Abeta oligomers

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01308

neuron projection maintenance

1 reference

8 April 2019

Protection of synapses against Alzheimer's-linked toxins: insulin signaling prevents the pathogenic binding of Abeta oligomers

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01308

response to L-arginine

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:C9JNR5

1 reference

9 May 2019

signal transduction

1 reference

9 May 2019

Gene Ontology Consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:C9JNR5

IEA

Gene Atlas image

PBB GE INS 206598 at fs.png
732 × 530; 8 KB

0 references

MCN code

2937.12.00

0 references

0 references

2 references

http://www.ebi.ac.uk/interpro/protein/C9JNR5

Insulin, conserved site

1 reference

Brockhaus Enzyklopädie online ID

different from

INS

0 references

Identifiers

1 reference

27 December 2019

1 reference

27 December 2019

1 reference

27 December 2019

1 reference

27 December 2019

1 reference

18 December 2019

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