Rapamycin partially prevents insulin resistance induced by chronic insulin treatment (Q40727110)

23 September 2017

Rapamycin partially prevents insulin resistance induced by chronic insulin treatment (English)

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23 September 2017

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Cathleen E Berg

1

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PubMed ID

12051762

23 September 2017

Brian E Lavan

series ordinal

2

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PubMed ID

12051762

23 September 2017

Cristina M Rondinone

series ordinal

3

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23 September 2017

1 May 2002

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Biochemical and Biophysical Research Communications

23 September 2017

7

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based on heuristic

inferred from page(s)

published in

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23 September 2017

293

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23 September 2017

1021-1027

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23 September 2017

3

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Insulin signal transduction and the IRS proteins

23 September 2017

1 reference

https://api.crossref.org/works/10.1016%2FS0006-291X%2802%2900333-9

The IRS-signalling system: a network of docking proteins that mediate insulin action

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-291X%2802%2900333-9

The pleckstrin homology domain is the principal link between the insulin receptor and IRS-1.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-291X%2802%2900333-9

Protein-protein interaction in insulin signaling and the molecular mechanisms of insulin resistance

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-291X%2802%2900333-9

Mechanism of activation and function of protein kinase B.

7 January 2021

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https://api.crossref.org/works/10.1016%2FS0006-291X%2802%2900333-9

Role of translocation in the activation and function of protein kinase B

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-291X%2802%2900333-9

Characterization of a 3-phosphoinositide-dependent protein kinase which phosphorylates and activates protein kinase Balpha

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-291X%2802%2900333-9

Protein kinase B/Akt participates in GLUT4 translocation by insulin in L6 myoblasts

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-291X%2802%2900333-9

PKB Inhibition Prevents the Stimulatory Effect of Insulin on Glucose Transport and Protein Translocation but Not the Antilipolytic Effect in Rat Adipocytes

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-291X%2802%2900333-9

Alternative pathway of insulin signalling in mice with targeted disruption of the IRS-1 gene.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-291X%2802%2900333-9

Insulin resistance and growth retardation in mice lacking insulin receptor substrate-1.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-291X%2802%2900333-9

Insulin receptor substrate (IRS) 1 is reduced and IRS-2 is the main docking protein for phosphatidylinositol 3-kinase in adipocytes from subjects with non-insulin-dependent diabetes mellitus

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-291X%2802%2900333-9

Regulation of insulin receptor substrate-1 in liver and muscle of animal models of insulin resistance

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-291X%2802%2900333-9

Insulin receptor phosphorylation, insulin receptor substrate-1 phosphorylation, and phosphatidylinositol 3-kinase activity are decreased in intact skeletal muscle strips from obese subjects

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-291X%2802%2900333-9

Altered expression levels and impaired steps in the pathway to phosphatidylinositol 3-kinase activation via insulin receptor substrates 1 and 2 in Zucker fatty rats.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-291X%2802%2900333-9

Differential regulation of insulin receptor substrates-1 and -2 (IRS-1 and IRS-2) and phosphatidylinositol 3-kinase isoforms in liver and muscle of the obese diabetic (ob/ob) mouse

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-291X%2802%2900333-9

Tumor necrosis factor-alpha-induced insulin resistance in 3T3-L1 adipocytes is accompanied by a loss of insulin receptor substrate-1 and GLUT4 expression without a loss of insulin receptor-mediated signal transduction.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-291X%2802%2900333-9

Development of insulin resistance in 3T3-L1 adipocytes

7 January 2021

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https://api.crossref.org/works/10.1016%2FS0006-291X%2802%2900333-9

Insulin stimulates the degradation of IRS-1 in 3T3-L1 adipocytes

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-291X%2802%2900333-9

The insulin receptor substrate (IRS-1) is a PEST protein that is susceptible to calpain degradation in vitro

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-291X%2802%2900333-9

Insulin-induced insulin receptor substrate-1 degradation is mediated by the proteasome degradation pathway.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-291X%2802%2900333-9

Serine/threonine phosphorylation of IRS-1 triggers its degradation: possible regulation by tyrosine phosphorylation

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-291X%2802%2900333-9

A rapamycin-sensitive pathway down-regulates insulin signaling via phosphorylation and proteasomal degradation of insulin receptor substrate-1.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-291X%2802%2900333-9

Mammalian target of rapamycin pathway regulates insulin signaling via subcellular redistribution of insulin receptor substrate 1 and integrates nutritional signals and metabolic signals of insulin

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-291X%2802%2900333-9

Impaired glucose transport and protein kinase B activation by insulin, but not okadaic acid, in adipocytes from subjects with Type II diabetes mellitus

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-291X%2802%2900333-9

Target of rapamycin (TOR): balancing the opposing forces of protein synthesis and degradation

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-291X%2802%2900333-9

Control of p70 s6 kinase by kinase activity of FRAP in vivo

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-291X%2802%2900333-9

Contrasting effects of IRS-1 versus IRS-2 gene disruption on carbohydrate and lipid metabolism in vivo.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-291X%2802%2900333-9

The functional significance of Shc in insulin signaling as a substrate of the insulin receptor

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-291X%2802%2900333-9

Characterization of signal transduction and glucose transport in skeletal muscle from type 2 diabetic patients

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-291X%2802%2900333-9

Insulin resistance differentially affects the PI 3-kinase- and MAP kinase-mediated signaling in human muscle

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-291X%2802%2900333-9

Characterization of selective resistance to insulin signaling in the vasculature of obese Zucker (fa/fa) rats

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-291X%2802%2900333-9

Cholesterol depletion disrupts caveolae and insulin receptor signaling for metabolic control via insulin receptor substrate-1, but not for mitogen-activated protein kinase control

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-291X%2802%2900333-9

Glucocorticoid-induced insulin resistance of protein synthesis is independent of the rapamycin-sensitive pathways in rat skeletal muscle

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-291X%2802%2900333-9

beta(3)-adrenergic stimulation differentially inhibits insulin signaling and decreases insulin-induced glucose uptake in brown adipocytes

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-291X%2802%2900333-9

Mechanism of activation of protein kinase B by insulin and IGF-1

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-291X%2802%2900333-9

Dual role of phosphatidylinositol-3,4,5-trisphosphate in the activation of protein kinase B

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-291X%2802%2900333-9

Insulin-stimulated protein kinase B phosphorylation on Ser-473 is independent of its activity and occurs through a staurosporine-insensitive kinase

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-291X%2802%2900333-9

The insulin receptor and its substrate: molecular determinants of early events in insulin action.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-291X%2802%2900333-9

inferred from DOI database lookup

7 January 2021

based on heuristic

Identifiers

DOI

10.1016/S0006-291X(02)00333-9

1 reference

23 September 2017

1 reference

PubMed ID

12051762