HoxA9 regulated Bcl-2 expression mediates survival of myeloid progenitors and the severity of HoxA9-dependent leukemia (Q42770287)

7 November 2017

HoxA9 regulated Bcl-2 expression mediates survival of myeloid progenitors and the severity of HoxA9-dependent leukemia (English)

1 reference

7 November 2017

12

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4 June 2020

Paul G Ekert

14

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4 June 2020

author name string

Gabriela Brumatti

1

1 reference

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4 June 2020

Marika Salmanidis

2

1 reference

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4 June 2020

Chung H Kok

3

1 reference

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4 June 2020

Rebecca A Bilardi

4

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4 June 2020

Jarrod J Sandow

5

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4 June 2020

Natasha Silke

6

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4 June 2020

Kylie Mason

7

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4 June 2020

Jolanda Visser

8

1 reference

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4 June 2020

Anissa M Jabbour

9

1 reference

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4 June 2020

Stefan P Glaser

10

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24177192%20AND%20SRC:MED&resulttype=core&format=json

4 June 2020

Toru Okamoto

11

1 reference

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4 June 2020

Richard J D'Andrea

13

1 reference

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4 June 2020

language of work or name

English

0 references

publication date

1 November 2013

1 reference

7 November 2017

15

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inferred from page(s)

published in

Oncotarget

1 reference

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4 June 2020

volume

4

1 reference

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4 June 2020

issue

11

1 reference

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4 June 2020

page(s)

1933-1947

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24177192%20AND%20SRC:MED&resulttype=core&format=json

Hoxb8 regulates expression of microRNAs to control cell death and differentiation.

4 June 2020

cites work

1 reference

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Relative mitochondrial priming of myeloblasts and normal HSCs determines chemotherapeutic success in AML

27 May 2018

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Anti-apoptotic Mcl-1 is essential for the development and sustained growth of acute myeloid leukemia

27 May 2018

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Identification and characterization of Hoxa9 binding sites in hematopoietic cells

27 May 2018

1 reference

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An integrated approach to dissecting oncogene addiction implicates a Myb-coordinated self-renewal program as essential for leukemia maintenance

27 May 2018

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Leukemogenic transformation by HOXA cluster genes.

27 May 2018

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Leukaemogenesis: more than mutant genes

27 May 2018

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HOXA9 is required for survival in human MLL-rearranged acute leukemias

27 May 2018

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Brief report: increased apoptosis in advanced atherosclerotic lesions of Apoe-/- mice lacking macrophage Bcl-2.

27 May 2018

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HOX expression patterns identify a common signature for favorable AML.

27 May 2018

1 reference

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Microenvironment determines lineage fate in a human model of MLL-AF9 leukemia

27 May 2018

1 reference

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Expression and purification of recombinant annexin V for the detection of membrane alterations on apoptotic cells

27 May 2018

1 reference

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The role of HOX genes in malignant myeloid disease

27 May 2018

1 reference

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The BH3 mimetic ABT-737 targets selective Bcl-2 proteins and efficiently induces apoptosis via Bak/Bax if Mcl-1 is neutralized.

27 May 2018

1 reference

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Identification and characterization of leukemia stem cells in murine MLL-AF9 acute myeloid leukemia.

27 May 2018

1 reference

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Transformation from committed progenitor to leukaemia stem cell initiated by MLL-AF9.

27 May 2018

1 reference

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Empirical array quality weights in the analysis of microarray data

27 May 2018

1 reference

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Cell death provoked by loss of interleukin-3 signaling is independent of Bad, Bim, and PI3 kinase, but depends in part on Puma

27 May 2018

1 reference

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Linear models and empirical bayes methods for assessing differential expression in microarray experiments

27 May 2018

1 reference

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Modulating Hox gene functions during animal body patterning

27 May 2018

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An inhibitor of Bcl-2 family proteins induces regression of solid tumours

27 May 2018

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An Mll-dependent Hox program drives hematopoietic progenitor expansion

27 May 2018

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Apaf-1 and caspase-9 accelerate apoptosis, but do not determine whether factor-deprived or drug-treated cells die

27 May 2018

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Expression of HOX genes in acute leukemia cell lines with and without MLL translocations

27 May 2018

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Transformation of myeloid progenitors by MLL oncoproteins is dependent on Hoxa7 and Hoxa9

27 May 2018

1 reference

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Structure of HoxA9 and Pbx1 bound to DNA: Hox hexapeptide and DNA recognition anterior to posterior

27 May 2018

1 reference

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Bmi-1 determines the proliferative capacity of normal and leukaemic stem cells

27 May 2018

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Rapid generation of inducible mouse mutants

27 May 2018

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Degenerative disorders caused by Bcl-2 deficiency prevented by loss of its BH3-only antagonist Bim

27 May 2018

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Inhibition of myeloid differentiation by Hoxa9, Hoxb8, and Meis homeobox genes

27 May 2018

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Conditional deletion of the Bcl-x gene from erythroid cells results in hemolytic anemia and profound splenomegaly

27 May 2018

1 reference

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HoxA9-mediated immortalization of myeloid progenitors requires functional interactions with TALE cofactors Pbx and Meis

27 May 2018

1 reference

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Molecular classification of cancer: class discovery and class prediction by gene expression monitoring

27 May 2018

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mcl-1 is an immediate-early gene activated by the granulocyte-macrophage colony-stimulating factor (GM-CSF) signaling pathway and is one component of the GM-CSF viability response

27 May 2018

1 reference

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Loss of function of the homeobox gene Hoxa-9 perturbs early T-cell development and induces apoptosis in primitive thymocytes.

27 May 2018

1 reference

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Inactivation of a c-Myb/estrogen receptor fusion protein in transformed primary cells leads to granulocyte/macrophage differentiation and down regulation of c-kit but not c-myc or cdc2.

27 May 2018

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AbdB-like Hox proteins stabilize DNA binding by the Meis1 homeodomain proteins

27 May 2018

1 reference

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Resistance to apoptosis in CTLL-2 cells constitutively expressing c-Myb is associated with induction of BCL-2 expression and Myb-dependent regulation of bcl-2 promoter activity

27 May 2018

1 reference

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Mice bearing a targeted interruption of the homeobox gene HOXA9 have defects in myeloid, erythroid, and lymphoid hematopoiesis.

27 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3875760

Hox homeodomain proteins exhibit selective complex stabilities with Pbx and DNA.

27 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3875760

Cooperative interactions between HOX and PBX proteins mediated by a conserved peptide motif

27 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3875760

A rapid and simple method for measuring thymocyte apoptosis by propidium iodide staining and flow cytometry

27 May 2018

1 reference

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Acute myeloid leukemia bearing t(7;11)(p15;p15) is a distinct cytogenetic entity with poor outcome and a distinct mutation profile: comparative analysis of 493 adult patients.

27 May 2018

1 reference

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Obligate role of anti-apoptotic MCL-1 in the survival of hematopoietic stem cells.

16 August 2018

1 reference

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Prognostically useful gene-expression profiles in acute myeloid leukemia.

16 August 2018

1 reference

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Gene expression signatures in MLL-rearranged T-lineage and B-precursor acute leukemias: dominance of HOX dysregulation.

16 August 2018

1 reference

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Gene expression analysis reveals HOX gene upregulation in trisomy 8 AML

16 August 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/24177192

12 December 2020

inferred from PubMed ID database lookup

Nup98-HoxA9 immortalizes myeloid progenitors, enforces expression of Hoxa9, Hoxa7 and Meis1, and alters cytokine-specific responses in a manner similar to that induced by retroviral co-expression of Hoxa9 and Meis1

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/24177192

12 December 2020

inferred from PubMed ID database lookup

High expression of bcl-2 protein in acute myeloid leukemia cells is associated with poor response to chemotherapy

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/24177192

12 December 2020

inferred from PubMed ID database lookup

Identifiers

DOI

10.18632/ONCOTARGET.1306

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24177192%20AND%20SRC:MED&resulttype=core&format=json

4 June 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24177192%20AND%20SRC:MED&resulttype=core&format=json

4 June 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24177192%20AND%20SRC:MED&resulttype=core&format=json