Trehalose alleviates polyglutamine-mediated pathology in a mouse model of Huntington disease (Q38345839)

2 September 2017

Trehalose alleviates polyglutamine-mediated pathology in a mouse model of Huntington disease (English)

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2 September 2017

alpha,alpha-trehalose

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Motomasa Tanaka

1

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2 September 2017

Yoko Machida

2

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2 September 2017

Sanyong Niu

3

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2 September 2017

Tetsurou Ikeda

4

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2 September 2017

Nihar R Jana

5

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2 September 2017

Hiroshi Doi

6

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2 September 2017

Masaru Kurosawa

7

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2 September 2017

Munenori Nekooki

8

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2 September 2017

Nobuyuki Nukina

9

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2 September 2017

language of work or name

English

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publication date

18 January 2004

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2 September 2017

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2 September 2017

10

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2 September 2017

148-154

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2 September 2017

2

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https://scigraph.springernature.com/pub.10.1038/nm985

2 September 2017

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cites work

Glutamine repeats and neurodegeneration

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7 January 2021

Huntingtin-encoded polyglutamine expansions form amyloid-like protein aggregates in vitro and in vivo

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7 January 2021

Formation of neuronal intranuclear inclusions underlies the neurological dysfunction in mice transgenic for the HD mutation

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7 January 2021

Expanded polyglutamine protein forms nuclear inclusions and causes neural degeneration in Drosophila.

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7 January 2021

A cellular model that recapitulates major pathogenic steps of Huntington's disease

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7 January 2021

Aggregation of huntingtin in neuronal intranuclear inclusions and dystrophic neurites in brain

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7 January 2021

Pathogenesis of polyglutamine disorders: aggregation revisited

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7 January 2021

Polyglutamine and CBP: fatal attraction?

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7 January 2021

Polyglutamine fibrillogenesis: the pathway unfolds

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7 January 2021

Huntingtin aggregation and toxicity in Huntington's disease

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7 January 2021

Inhibition of caspase-1 slows disease progression in a mouse model of Huntington's disease

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7 January 2021

Chaperone suppression of aggregation and altered subcellular proteasome localization imply protein misfolding in SCA1.

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7 January 2021

Polyglutamine length-dependent interaction of Hsp40 and Hsp70 family chaperones with truncated N-terminal huntingtin: their role in suppression of aggregation and cellular toxicity

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7 January 2021

Expanded polyglutamine stretches interact with TAFII130, interfering with CREB-dependent transcription

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7 January 2021

Recruitment and the role of nuclear localization in polyglutamine-mediated aggregation

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7 January 2021

Epidermal immunization by a needle-free powder delivery technology: Immunogenicity of influenza vaccine and protection in mice

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7 January 2021

Neuroprotective effects of creatine in a transgenic mouse model of Huntington's disease.

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7 January 2021

Suberoylanilide hydroxamic acid, a histone deacetylase inhibitor, ameliorates motor deficits in a mouse model of Huntington's disease

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7 January 2021

Pivotal role of oligomerization in expanded polyglutamine neurodegenerative disorders.

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7 January 2021

Therapeutic opportunities in polyglutamine disease

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7 January 2021

Inhibition of huntingtin fibrillogenesis by specific antibodies and small molecules: implications for Huntington's disease therapy

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7 January 2021

Identification of benzothiazoles as potential polyglutamine aggregation inhibitors of Huntington's disease by using an automated filter retardation assay

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7 January 2021

Intra- and intermolecular beta-pleated sheet formation in glutamine-repeat inserted myoglobin as a model for polyglutamine diseases

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7 January 2021

The effects of aggregation-inducing motifs on amyloid formation of model proteins related to neurodegenerative diseases.

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7 January 2021

Inhibition of polyglutamine protein aggregation and cell death by novel peptides identified by phage display screening

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7 January 2021

Trifluoroethanol stabilizes the pH 4 folding intermediate of sperm whale apomyoglobin.

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7 January 2021

Caspase activation during apoptotic cell death induced by expanded polyglutamine in N2a cells.

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7 January 2021

Trehalose expression confers desiccation tolerance on human cells

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7 January 2021

Exon 1 of the HD gene with an expanded CAG repeat is sufficient to cause a progressive neurological phenotype in transgenic mice

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7 January 2021

Formation of polyglutamine inclusions in non-CNS tissue

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7 January 2021

Huntingtin spheroids and protofibrils as precursors in polyglutamine fibrilization

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7 January 2021

Increased motoneuron survival and improved neuromuscular function in transgenic ALS mice after intraspinal injection of an adeno-associated virus encoding Bcl-2.

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7 January 2021

Mice transgenic for an expanded CAG repeat in the Huntington's disease gene develop diabetes

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7 January 2021

Multiple effects of trehalose on protein folding in vitro and in vivo

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7 January 2021

A bivalent Huntingtin binding peptide suppresses polyglutamine aggregation and pathogenesis in Drosophila

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7 January 2021

Aggregated polyglutamine peptides delivered to nuclei are toxic to mammalian cells

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7 January 2021

Caspase cleavage of gene products associated with triplet expansion disorders generates truncated fragments containing the polyglutamine tract

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7 January 2021

Trehalose synthesis is induced upon exposure of Escherichia coli to cold and is essential for viability at low temperatures

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7 January 2021

Identifiers

DOI

10.1038/NM985

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Dimensions Publication ID

2 September 2017

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