Polyglutamine-expanded ataxin-7 promotes non-cell-autonomous purkinje cell degeneration and displays proteolytic cleavage in ataxic transgenic mice. (Q48572020)

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English	Polyglutamine-expanded ataxin-7 promotes non-cell-autonomous purkinje cell degeneration and displays proteolytic cleavage in ataxic transgenic mice.	scientific article

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Europe PubMed Central

12 February 2018

http://europepmc.org/abstract/MED/12077187

Polyglutamine-expanded ataxin-7 promotes non-cell-autonomous purkinje cell degeneration and displays proteolytic cleavage in ataxic transgenic mice (English)

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12 May 2020

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author name string

Gwenn A Garden

1

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12 May 2020

Randell T Libby

2

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12 May 2020

Ying-Hui Fu

3

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12 May 2020

Yoshito Kinoshita

4

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12 May 2020

Jing Huang

5

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12 May 2020

Daniel E Possin

6

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12 May 2020

Annette C Smith

7

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12 May 2020

Refugio A Martinez

8

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12 May 2020

Gabriel C Fine

9

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12 May 2020

Sara K Grote

10

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12 May 2020

Carol B Ware

11

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12 May 2020

David D Einum

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12 May 2020

Richard S Morrison

13

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12 May 2020

Louis J Ptacek

14

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12 May 2020

Bryce L Sopher

15

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12 May 2020

Albert R La Spada

16

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12 May 2020

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publication date

1 June 2002

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12 February 2018

http://europepmc.org/abstract/MED/12077187

Journal of Neuroscience

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12 May 2020

22

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12 May 2020

4897-4905

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12 May 2020

12

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12 May 2020

A YAC mouse model for Huntington's disease with full-length mutant huntingtin, cytoplasmic toxicity, and selective striatal neurodegeneration.

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https://pubmed.ncbi.nlm.nih.gov/12077187

12 December 2020

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Mutation of the E6-AP ubiquitin ligase reduces nuclear inclusion frequency while accelerating polyglutamine-induced pathology in SCA1 mice.

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https://pubmed.ncbi.nlm.nih.gov/12077187

12 December 2020

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Nuclear accumulation of truncated atrophin-1 fragments in a transgenic mouse model of DRPLA.

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https://pubmed.ncbi.nlm.nih.gov/12077187

12 December 2020

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Glutamine repeats and neurodegeneration

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https://pubmed.ncbi.nlm.nih.gov/12077187

12 December 2020

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Expression analysis of ataxin-7 mRNA and protein in human brain: evidence for a widespread distribution and focal protein accumulation

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https://pubmed.ncbi.nlm.nih.gov/12077187

12 December 2020

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CREB-binding protein sequestration by expanded polyglutamine

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https://pubmed.ncbi.nlm.nih.gov/12077187

12 December 2020

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Expanded polyglutamines induce neurodegeneration and trans-neuronal alterations in cerebellum and retina of SCA7 transgenic mice

1 reference

https://pubmed.ncbi.nlm.nih.gov/12077187

12 December 2020

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Polyglutamine disease and neuronal cell death.

1 reference

https://pubmed.ncbi.nlm.nih.gov/12077187

12 December 2020

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Neurological abnormalities in a knock-in mouse model of Huntington's disease

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https://pubmed.ncbi.nlm.nih.gov/12077187

12 December 2020

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Ataxin-7 expression analysis in controls and spinocerebellar ataxia type 7 patients

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https://pubmed.ncbi.nlm.nih.gov/12077187

12 December 2020

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Loss of huntingtin-mediated BDNF gene transcription in Huntington's disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/12077187

12 December 2020

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SCA17, a novel autosomal dominant cerebellar ataxia caused by an expanded polyglutamine in TATA-binding protein

1 reference

https://pubmed.ncbi.nlm.nih.gov/12077187

12 December 2020

based on heuristic

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Cause of neural death in neurodegenerative diseases attributable to expansion of glutamine repeats

1 reference

https://pubmed.ncbi.nlm.nih.gov/12077187

12 December 2020

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SCA7 mouse models show selective stabilization of mutant ataxin-7 and similar cellular responses in different neuronal cell types

1 reference

https://pubmed.ncbi.nlm.nih.gov/12077187

12 December 2020

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Nerve growth factor signaling, neuroprotection, and neural repair

1 reference

https://pubmed.ncbi.nlm.nih.gov/12077187

12 December 2020

based on heuristic

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Qs in the nucleus.

1 reference

https://pubmed.ncbi.nlm.nih.gov/12077187

12 December 2020

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Polyglutamine-expanded ataxin-7 antagonizes CRX function and induces cone-rod dystrophy in a mouse model of SCA7

1 reference

https://pubmed.ncbi.nlm.nih.gov/12077187

12 December 2020

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Mutant protein in Huntington disease is resistant to proteolysis in affected brain

1 reference

https://pubmed.ncbi.nlm.nih.gov/12077187

12 December 2020

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Similarities between spinocerebellar ataxia type 7 (SCA7) cell models and human brain: proteins recruited in inclusions and activation of caspase-3.

1 reference

https://pubmed.ncbi.nlm.nih.gov/12077187

12 December 2020

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BDNF as an anterophin; a novel neurotrophic relationship between brain neurons

1 reference

https://pubmed.ncbi.nlm.nih.gov/12077187

12 December 2020

based on heuristic

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Hereditary olivopontocerebellar atrophy with retinal degeneration. Report of a family through six generations.

1 reference

https://pubmed.ncbi.nlm.nih.gov/12077187

12 December 2020

based on heuristic

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Polyglutamine expansion as a pathological epitope in Huntington's disease and four dominant cerebellar ataxias

1 reference

https://pubmed.ncbi.nlm.nih.gov/12077187

12 December 2020

based on heuristic

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Autosomal dominant cerebellar ataxia with pigmentary macular dystrophy. A clinical and genetic study of eight families.

1 reference

https://pubmed.ncbi.nlm.nih.gov/12077187

12 December 2020

based on heuristic

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A vector for expressing foreign genes in the brains and hearts of transgenic mice

1 reference

https://pubmed.ncbi.nlm.nih.gov/12077187

12 December 2020

based on heuristic

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Huntington's disease and dentatorubral-pallidoluysian atrophy: proteins, pathogenesis and pathology

1 reference

https://pubmed.ncbi.nlm.nih.gov/12077187

12 December 2020

based on heuristic

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Cloning of the SCA7 gene reveals a highly unstable CAG repeat expansion

1 reference

https://pubmed.ncbi.nlm.nih.gov/12077187

12 December 2020

based on heuristic

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Intranuclear neuronal inclusions: a common pathogenic mechanism for glutamine-repeat neurodegenerative diseases?

1 reference

https://pubmed.ncbi.nlm.nih.gov/12077187

12 December 2020

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Caspase cleavage of gene products associated with triplet expansion disorders generates truncated fragments containing the polyglutamine tract

1 reference

https://pubmed.ncbi.nlm.nih.gov/12077187

12 December 2020

based on heuristic

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Spinocerebellar ataxia type 7 (SCA7): a neurodegenerative disorder with neuronal intranuclear inclusions.

1 reference

https://pubmed.ncbi.nlm.nih.gov/12077187

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Intranuclear neuronal inclusions in Huntington's disease and dentatorubral and pallidoluysian atrophy: correlation between the density of inclusions and IT15 CAG triplet repeat length

1 reference

https://pubmed.ncbi.nlm.nih.gov/12077187

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Nuclear inclusions of the androgen receptor protein in spinal and bulbar muscular atrophy.

1 reference

https://pubmed.ncbi.nlm.nih.gov/12077187

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Properties of the caspases

1 reference

https://pubmed.ncbi.nlm.nih.gov/12077187

12 December 2020

based on heuristic

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Nuclear inclusions in glutamine repeat disorders: are they pernicious, coincidental, or beneficial?

1 reference

https://pubmed.ncbi.nlm.nih.gov/12077187

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Ataxin-1 nuclear localization and aggregation: role in polyglutamine-induced disease in SCA1 transgenic mice.

1 reference

https://pubmed.ncbi.nlm.nih.gov/12077187

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Huntingtin acts in the nucleus to induce apoptosis but death does not correlate with the formation of intranuclear inclusions.

1 reference

https://pubmed.ncbi.nlm.nih.gov/12077187

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Kennedy's disease: caspase cleavage of the androgen receptor is a crucial event in cytotoxicity

1 reference

https://pubmed.ncbi.nlm.nih.gov/12077187

12 December 2020

based on heuristic

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Intranuclear inclusions and neuritic aggregates in transgenic mice expressing a mutant N-terminal fragment of huntingtin

1 reference

https://pubmed.ncbi.nlm.nih.gov/12077187

12 December 2020

based on heuristic

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Protein fate in neurodegenerative proteinopathies: polyglutamine diseases join the (mis)fold

1 reference

https://pubmed.ncbi.nlm.nih.gov/12077187

12 December 2020

based on heuristic

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Identifiers

10.1523/JNEUROSCI.22-12-04897.2002

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6757746&resulttype=core&format=json

12 May 2020

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6757746&resulttype=core&format=json

12 May 2020

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6757746&resulttype=core&format=json

12 May 2020

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