The DNA damage signaling pathway is a critical mediator of oncogene-induced senescence. (Q42123048)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17210786%20AND%20SRC:MED&resulttype=core&format=json

23 December 2019

title

The DNA damage signaling pathway is a critical mediator of oncogene-induced senescence (English)

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23 December 2019

0 references

1

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23 December 2019

Gerardo Ferbeyre

series ordinal

3

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23 December 2019

author name string

Marie-France Gaumont-Leclerc

series ordinal

2

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23 December 2019

publication date

1 January 2007

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23 December 2019

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23 December 2019

volume

21

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23 December 2019

issue

1

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23 December 2019

page(s)

43-48

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DNA damage signaling and p53-dependent senescence after prolonged beta-interferon stimulation

23 December 2019

cites work

1 reference

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Activation of the DNA damage checkpoint and genomic instability in human precancerous lesions

29 May 2018

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DNA damage response as a candidate anti-cancer barrier in early human tumorigenesis

29 May 2018

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Regulation of cellular response to oncogenic and oxidative stress by Seladin-1

29 May 2018

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Intrinsic tumour suppression

29 May 2018

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PEA-15 is inhibited by adenovirus E1A and plays a role in ERK nuclear export and Ras-induced senescence

29 May 2018

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Arf tumor suppressor promoter monitors latent oncogenic signals in vivo

29 May 2018

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A DNA damage checkpoint response in telomere-initiated senescence

29 May 2018

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High Intensity ras Signaling Induces Premature Senescence by Activating p38 Pathway in Primary Human Fibroblasts

29 May 2018

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Chromatin assembly factor 1 is essential and couples chromatin assembly to DNA replication in vivo

29 May 2018

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DNA damage activates ATM through intermolecular autophosphorylation and dimer dissociation

29 May 2018

1 reference

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53BP1 functions in an ATM-dependent checkpoint pathway that is constitutively activated in human cancer

29 May 2018

1 reference

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Checking on the fork: the DNA-replication stress-response pathway

29 May 2018

1 reference

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53BP1, a mediator of the DNA damage checkpoint

29 May 2018

1 reference

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Interfaces between the detection, signaling, and repair of DNA damage

29 May 2018

1 reference

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Chk1 is activated transiently and targets Cdc25A for degradation at the Xenopus midblastula transition

29 May 2018

1 reference

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Chk2 activation and phosphorylation-dependent oligomerization

29 May 2018

1 reference

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Oncogenic ras and p53 cooperate to induce cellular senescence

29 May 2018

1 reference

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p19(ARF) is dispensable for oncogenic stress-induced p53-mediated apoptosis and tumor suppression in vivo

29 May 2018

1 reference

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Role of p14(ARF) in replicative and induced senescence of human fibroblasts

29 May 2018

1 reference

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ATR-mediated checkpoint pathways regulate phosphorylation and activation of human Chk1

29 May 2018

1 reference

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Oncogenic ras activates the ARF-p53 pathway to suppress epithelial cell transformation

29 May 2018

1 reference

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Ablation of the retinoblastoma gene family deregulates G(1) control causing immortalization and increased cell turnover under growth-restricting conditions

29 May 2018

1 reference

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Ataxia telangiectasia-mutated phosphorylates Chk2 in vivo and in vitro

29 May 2018

1 reference

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PML is induced by oncogenic ras and promotes premature senescence

29 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1759898

PML regulates p53 acetylation and premature senescence induced by oncogenic Ras

29 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1759898

29 May 2018

1 reference

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Regulation of a senescence checkpoint response by the E2F1 transcription factor and p14(ARF) tumor suppressor

29 May 2018

1 reference

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Expression of catalytically active telomerase does not prevent premature senescence caused by overexpression of oncogenic Ha-Ras in normal human fibroblasts

29 May 2018

1 reference

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Absence of cancer-associated changes in human fibroblasts immortalized with telomerase

29 May 2018

1 reference

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E1A signaling to p53 involves the p19(ARF) tumor suppressor

29 May 2018

1 reference

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Myc signaling via the ARF tumor suppressor regulates p53-dependent apoptosis and immortalization

29 May 2018

1 reference

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Identification and characterization of a constitutively active STAT5 mutant that promotes cell proliferation

29 May 2018

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Oncogenic ras provokes premature cell senescence associated with accumulation of p53 and p16INK4a

29 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1759898

RNA silencing of checkpoint regulators sensitizes p53-defective prostate cancer cells to chemotherapy while sparing normal cells

29 May 2018

1 reference

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Human fibroblasts require the Rb family of tumor suppressors, but not p53, for PML-induced senescence.

17 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1759898

Ataxia-telangiectasia-mutated (ATM) and NBS1-dependent phosphorylation of Chk1 on Ser-317 in response to ionizing radiation

17 August 2018

1 reference

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Escape from premature senescence is not sufficient for oncogenic transformation by Ras.

17 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1759898

p19ARF links the tumour suppressor p53 to Ras

17 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1759898

c-Myc can induce DNA damage, increase reactive oxygen species, and mitigate p53 function: a mechanism for oncogene-induced genetic instability

1 December 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/17210786

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Ras proteins induce senescence by altering the intracellular levels of reactive oxygen species

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/17210786

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Defective S phase chromatin assembly causes DNA damage, activation of the S phase checkpoint, and S phase arrest

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/17210786

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1101/GAD.1487307

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17210786%20AND%20SRC:MED&resulttype=core&format=json

23 December 2019

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17210786%20AND%20SRC:MED&resulttype=core&format=json

23 December 2019

1 reference