Checking on the fork: the DNA-replication stress-response pathway (Q35006441)

5 August 2017

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title

Checking on the fork: the DNA-replication stress-response pathway (English)

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5 August 2017

Alexander J Osborn

1

1 reference

PubMed ID

12446112

5 August 2017

Stephen J Elledge

series ordinal

2

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PubMed ID

12446112

5 August 2017

Lee Zou

series ordinal

3

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5 August 2017

1 November 2002

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5 August 2017

Trends in Cell Biology

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5 August 2017

12

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5 August 2017

509-516

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5 August 2017

11

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Suppression of spontaneous chromosomal rearrangements by S phase checkpoint functions in Saccharomyces cerevisiae

5 August 2017

1 reference

https://api.crossref.org/works/10.1016%2FS0962-8924%2802%2902380-2

7 January 2021

The DNA damage response: putting checkpoints in perspective

1 reference

https://api.crossref.org/works/10.1016%2FS0962-8924%2802%2902380-2

7 January 2021

The novel DNA damage checkpoint protein ddc1p is phosphorylated periodically during the cell cycle and in response to DNA damage in budding yeast.

1 reference

https://api.crossref.org/works/10.1016%2FS0962-8924%2802%2902380-2

7 January 2021

Mutational effect of fission yeast polalpha on cell cycle events

1 reference

https://api.crossref.org/works/10.1016%2FS0962-8924%2802%2902380-2

7 January 2021

Regulation of DNA replication fork progression through damaged DNA by the Mec1/Rad53 checkpoint

1 reference

https://api.crossref.org/works/10.1016%2FS0962-8924%2802%2902380-2

7 January 2021

Cell cycle progression in the presence of irreparable DNA damage is controlled by a Mec1- and Rad53-dependent checkpoint in budding yeast

1 reference

https://api.crossref.org/works/10.1016%2FS0962-8924%2802%2902380-2

7 January 2021

The Xenopus Chk1 protein kinase mediates a caffeine-sensitive pathway of checkpoint control in cell-free extracts

1 reference

https://api.crossref.org/works/10.1016%2FS0962-8924%2802%2902380-2

7 January 2021

S phase and G2 arrests induced by topoisomerase I poisons are dependent on ATR kinase function

1 reference

https://api.crossref.org/works/10.1016%2FS0962-8924%2802%2902380-2

7 January 2021

The ATM homologue MEC1 is required for phosphorylation of replication protein A in yeast

1 reference

https://api.crossref.org/works/10.1016%2FS0962-8924%2802%2902380-2

7 January 2021

The Dun1 checkpoint kinase phosphorylates and regulates the ribonucleotide reductase inhibitor Sml1.

1 reference

https://api.crossref.org/works/10.1016%2FS0962-8924%2802%2902380-2

7 January 2021

ATR homolog Mec1 promotes fork progression, thus averting breaks in replication slow zones.

1 reference

https://api.crossref.org/works/10.1016%2FS0962-8924%2802%2902380-2

7 January 2021

Requirement for Atr in phosphorylation of Chk1 and cell cycle regulation in response to DNA replication blocks and UV-damaged DNA in Xenopus egg extracts

1 reference

https://api.crossref.org/works/10.1016%2FS0962-8924%2802%2902380-2

7 January 2021

ATR and ATRIP: partners in checkpoint signaling

1 reference

https://api.crossref.org/works/10.1016%2FS0962-8924%2802%2902380-2

7 January 2021

A Rad3–Rad26 complex responds to DNA damage independently of other checkpoint proteins

1 reference

https://api.crossref.org/works/10.1016%2FS0962-8924%2802%2902380-2

7 January 2021

Pie1, a protein interacting with Mec1, controls cell growth and checkpoint responses in Saccharomyces cerevisiae

1 reference

https://api.crossref.org/works/10.1016%2FS0962-8924%2802%2902380-2

7 January 2021

LCD1: an essential gene involved in checkpoint control and regulation of the MEC1 signalling pathway in Saccharomyces cerevisiae

1 reference

https://api.crossref.org/works/10.1016%2FS0962-8924%2802%2902380-2

7 January 2021

Recruitment of Mec1 and Ddc1 checkpoint proteins to double-strand breaks through distinct mechanisms

1 reference

https://api.crossref.org/works/10.1016%2FS0962-8924%2802%2902380-2

7 January 2021

Lcd1p recruits Mec1p to DNA lesions in vitro and in vivo

1 reference

https://api.crossref.org/works/10.1016%2FS0962-8924%2802%2902380-2

7 January 2021

Preferential binding of ATR protein to UV-damaged DNA.

1 reference

https://api.crossref.org/works/10.1016%2FS0962-8924%2802%2902380-2

7 January 2021

Xenopus ATR is a replication-dependent chromatin-binding protein required for the DNA replication checkpoint

1 reference

https://api.crossref.org/works/10.1016%2FS0962-8924%2802%2902380-2

7 January 2021

The role of single-stranded DNA and polymerase alpha in establishing the ATR, Hus1 DNA replication checkpoint

1 reference

https://api.crossref.org/works/10.1016%2FS0962-8924%2802%2902380-2

7 January 2021

The G2-phase DNA-damage checkpoint

1 reference

https://api.crossref.org/works/10.1016%2FS0962-8924%2802%2902380-2

7 January 2021

Purification and characterization of human DNA damage checkpoint Rad complexes

1 reference

https://api.crossref.org/works/10.1016%2FS0962-8924%2802%2902380-2

7 January 2021

Structures of the human Rad17-replication factor C and checkpoint Rad 9-1-1 complexes visualized by glycerol spray/low voltage microscopy

1 reference

https://api.crossref.org/works/10.1016%2FS0962-8924%2802%2902380-2

7 January 2021

Clamp and clamp loader structures of the human checkpoint protein complexes, Rad9-1-1 and Rad17-RFC.

1 reference

https://api.crossref.org/works/10.1016%2FS0962-8924%2802%2902380-2

7 January 2021

Regulation of ATR substrate selection by Rad17-dependent loading of Rad9 complexes onto chromatin

1 reference

https://api.crossref.org/works/10.1016%2FS0962-8924%2802%2902380-2

7 January 2021

Activation of the DNA replication checkpoint through RNA synthesis by primase

1 reference

https://api.crossref.org/works/10.1016%2FS0962-8924%2802%2902380-2

7 January 2021

Hus1 acts upstream of chk1 in a mammalian DNA damage response pathway

1 reference

https://api.crossref.org/works/10.1016%2FS0962-8924%2802%2902380-2

7 January 2021

ATR/ATM-mediated phosphorylation of human Rad17 is required for genotoxic stress responses

1 reference

https://api.crossref.org/works/10.1016%2FS0962-8924%2802%2902380-2

7 January 2021

Phosphorylation of serines 635 and 645 of human Rad17 is cell cycle regulated and is required for G(1)/S checkpoint activation in response to DNA damage

1 reference

https://api.crossref.org/works/10.1016%2FS0962-8924%2802%2902380-2

7 January 2021

ATM-dependent phosphorylation of human Rad9 is required for ionizing radiation-induced checkpoint activation

1 reference

https://api.crossref.org/works/10.1016%2FS0962-8924%2802%2902380-2

7 January 2021

DNA polymerase epsilon links the DNA replication machinery to the S phase checkpoint

1 reference

https://api.crossref.org/works/10.1016%2FS0962-8924%2802%2902380-2

7 January 2021

Dpb11, which interacts with DNA polymerase II(epsilon) in Saccharomyces cerevisiae, has a dual role in S-phase progression and at a cell cycle checkpoint

1 reference

https://api.crossref.org/works/10.1016%2FS0962-8924%2802%2902380-2

7 January 2021

DRC1, DNA replication and checkpoint protein 1, functions with DPB11 to control DNA replication and the S-phase checkpoint in Saccharomyces cerevisiae

1 reference

https://api.crossref.org/works/10.1016%2FS0962-8924%2802%2902380-2

7 January 2021

BRCT domain-containing protein TopBP1 functions in DNA replication and damage response

1 reference

https://api.crossref.org/works/10.1016%2FS0962-8924%2802%2902380-2

7 January 2021

The 70 kDa subunit of replication protein A is required for the G1/S and intra-S DNA damage checkpoints in budding yeast

1 reference

https://api.crossref.org/works/10.1016%2FS0962-8924%2802%2902380-2

7 January 2021

A role for DNA primase in coupling DNA replication to DNA damage response.

1 reference

https://api.crossref.org/works/10.1016%2FS0962-8924%2802%2902380-2

7 January 2021

Analysis of fission yeast primase defines the checkpoint responses to aberrant S phase initiation

1 reference

https://api.crossref.org/works/10.1016%2FS0962-8924%2802%2902380-2

7 January 2021

Claspin, a novel protein required for the activation of Chk1 during a DNA replication checkpoint response in Xenopus egg extracts

1 reference

https://api.crossref.org/works/10.1016%2FS0962-8924%2802%2902380-2

7 January 2021

Substrate specificities and identification of putative substrates of ATM kinase family members

1 reference

https://api.crossref.org/works/10.1016%2FS0962-8924%2802%2902380-2

7 January 2021

Budding yeast Rad9 is an ATP-dependent Rad53 activating machine.

1 reference

https://api.crossref.org/works/10.1016%2FS0962-8924%2802%2902380-2

7 January 2021

Rad53 FHA domain associated with phosphorylated Rad9 in the DNA damage checkpoint

1 reference

https://api.crossref.org/works/10.1016%2FS0962-8924%2802%2902380-2

7 January 2021

Rad9 phosphorylation sites couple Rad53 to the Saccharomyces cerevisiae DNA damage checkpoint

1 reference

https://api.crossref.org/works/10.1016%2FS0962-8924%2802%2902380-2

7 January 2021

Mrc1 transduces signals of DNA replication stress to activate Rad53.

1 reference

https://api.crossref.org/works/10.1016%2FS0962-8924%2802%2902380-2

7 January 2021

Mrc1 channels the DNA replication arrest signal to checkpoint kinase Cds1.

1 reference

https://api.crossref.org/works/10.1016%2FS0962-8924%2802%2902380-2

7 January 2021

Recovery from DNA replicational stress is the essential function of the S-phase checkpoint pathway

1 reference

https://api.crossref.org/works/10.1016%2FS0962-8924%2802%2902380-2

7 January 2021

The DNA replication checkpoint response stabilizes stalled replication forks

1 reference

https://api.crossref.org/works/10.1016%2FS0962-8924%2802%2902380-2

7 January 2021

Fork reversal and ssDNA accumulation at stalled replication forks owing to checkpoint defects

1 reference

https://api.crossref.org/works/10.1016%2FS0962-8924%2802%2902380-2

7 January 2021

Structural analysis of DNA replication fork reversal by RecG

1 reference

https://api.crossref.org/works/10.1016%2FS0962-8924%2802%2902380-2

7 January 2021

RuvAB acts at arrested replication forks

1 reference

https://api.crossref.org/works/10.1016%2FS0962-8924%2802%2902380-2

7 January 2021

Rescue of arrested replication forks by homologous recombination

1 reference

https://api.crossref.org/works/10.1016%2FS0962-8924%2802%2902380-2

7 January 2021

The Bloom's syndrome gene product promotes branch migration of holliday junctions

1 reference

https://api.crossref.org/works/10.1016%2FS0962-8924%2802%2902380-2

7 January 2021

Branch migration and Holliday junction resolution catalyzed by activities from mammalian cells

1 reference

https://api.crossref.org/works/10.1016%2FS0962-8924%2802%2902380-2

7 January 2021

Mus81-Eme1 are essential components of a Holliday junction resolvase

1 reference

https://api.crossref.org/works/10.1016%2FS0962-8924%2802%2902380-2

7 January 2021

Human Mus81-associated endonuclease cleaves Holliday junctions in vitro

1 reference

https://api.crossref.org/works/10.1016%2FS0962-8924%2802%2902380-2

7 January 2021

MUS81 encodes a novel helix-hairpin-helix protein involved in the response to UV- and methylation-induced DNA damage in Saccharomyces cerevisiae

1 reference

https://api.crossref.org/works/10.1016%2FS0962-8924%2802%2902380-2

7 January 2021

Bloom's syndrome protein is required for correct relocalization of RAD50/MRE11/NBS1 complex after replication fork arrest

1 reference

https://api.crossref.org/works/10.1016%2FS0962-8924%2802%2902380-2

7 January 2021

Damage tolerance protein Mus81 associates with the FHA1 domain of checkpoint kinase Cds1

1 reference

https://api.crossref.org/works/10.1016%2FS0962-8924%2802%2902380-2

7 January 2021

10.1016/S0962-8924(02)02380-2

Identifiers

DOI

1 reference

5 August 2017

1 reference

PubMed ID

12446112