Tpl2 regulates intestinal myofibroblast HGF release to suppress colitis-associated tumorigenesis. (Q41626594)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23064365%20AND%20SRC:MED&resulttype=core&format=json

10 March 2020

title

Tpl2 regulates intestinal myofibroblast HGF release to suppress colitis-associated tumorigenesis (English)

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10 March 2020

3

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10 March 2020

Vasiliki Koliaraki

1

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23064365%20AND%20SRC:MED&resulttype=core&format=json

10 March 2020

Manolis Roulis

2

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10 March 2020

author name string

Vasiliki Koliaraki

1

1 reference

5 October 2017

Manolis Roulis

2

1 reference

5 October 2017

language of work or name

English

0 references

publication date

15 October 2012

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23064365%20AND%20SRC:MED&resulttype=core&format=json

Journal of Clinical Investigation

10 March 2020

published in

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10 March 2020

volume

122

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10 March 2020

page(s)

4231-4242

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10 March 2020

issue

11

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Tpl2 ablation promotes intestinal inflammation and tumorigenesis in Apcmin mice by inhibiting IL-10 secretion and regulatory T-cell generation.

10 March 2020

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6 October 2017

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6 October 2017

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6 October 2017

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Tpl-2/Cot and COX-2 in breast cancer.

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6 October 2017

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6 October 2017

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6 October 2017

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Tpl2 and ERK transduce antiproliferative T cell receptor signals and inhibit transformation of chronically stimulated T cells.

6 October 2017

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6 October 2017

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6 October 2017

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6 October 2017

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6 October 2017

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6 October 2017

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6 October 2017

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6 October 2017

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6 October 2017

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6 October 2017

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6 October 2017

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6 October 2017

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Tpl2 transduces CD40 and TNF signals that activate ERK and regulates IgE induction by CD40.

6 October 2017

1 reference

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Genetic dissection of the cellular pathways and signaling mechanisms in modeled tumor necrosis factor-induced Crohn's-like inflammatory bowel disease

6 October 2017

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Induction of COX-2 by LPS in macrophages is regulated by Tpl2-dependent CREB activation signals.

6 October 2017

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The role of transforming growth factor beta-2, beta-3 in mediating apoptosis in the murine intestinal mucosa.

6 October 2017

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Inflammation and cancer: back to Virchow?

6 October 2017

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TNF-alpha induction by LPS is regulated posttranscriptionally via a Tpl2/ERK-dependent pathway

6 October 2017

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Mechanism of regulation of HGF/SF gene expression in fibroblasts by TGF-beta1.

6 October 2017

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6 October 2017

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Tpl-2 is an oncogenic kinase that is activated by carboxy-terminal truncation

6 October 2017

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Involvement of the Tpl-2/cot oncogene in MMTV tumorigenesis

6 October 2017

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6 October 2017

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6 October 2017

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6 October 2017

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Identification of the cells expressing cot proto-oncogene mRNA.

6 October 2017

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6 October 2017

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6 October 2017

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Genetic and pharmacological targeting of TPL-2 kinase ameliorates experimental colitis: a potential target for the treatment of Crohn's disease?

6 October 2017

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Pharmacologic inhibition of tpl2 blocks inflammatory responses in primary human monocytes, synoviocytes, and blood.

19 August 2018

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19 August 2018

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Tpl2/cot signals activate ERK, JNK, and NF-kappaB in a cell-type and stimulus-specific manner.

19 August 2018

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Synergistic induction of hepatocyte growth factor in human skin fibroblasts by the inflammatory cytokines interleukin-1 and interferon-gamma.

19 August 2018

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Tissue-specific and inducible Cre-mediated recombination in the gut epithelium

19 August 2018

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Cis elements of the villin gene control expression in restricted domains of the vertical (crypt) and horizontal (duodenum, cecum) axes of the intestine.

19 August 2018

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19 August 2018

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Analysis of clinical, ultrasound and colour flow-Doppler characteristics in predicting malignancy in follicular thyroid neoplasms

19 August 2018

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12 December 2020

Enhancement of human hepatocyte growth factor production by interleukin-1 alpha and -1 beta and tumor necrosis factor-alpha by fibroblasts in culture

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12 December 2020

Overexpression of the Tpl-2/Cot oncogene in human breast cancer

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12 December 2020

Induction of hepatocyte growth factor in fibroblasts by tumor-derived factors affects invasive growth of tumor cells: in vitro analysis of tumor-stromal interactions

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12 December 2020

Identifiers

DOI

10.1172/JCI63917

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23064365%20AND%20SRC:MED&resulttype=core&format=json

10 March 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23064365%20AND%20SRC:MED&resulttype=core&format=json

10 March 2020

1 reference