Genetic and pharmacological targeting of TPL-2 kinase ameliorates experimental colitis: a potential target for the treatment of Crohn's disease? (Q52891216)

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scientific article published on 7 December 2011

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English	Genetic and pharmacological targeting of TPL-2 kinase ameliorates experimental colitis: a potential target for the treatment of Crohn's disease?	scientific article published on 7 December 2011

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scholarly article

1 reference

Europe PubMed Central

PubMed publication ID

9 May 2018

http://europepmc.org/abstract/MED/22157885

Genetic and pharmacological targeting of TPL-2 kinase ameliorates experimental colitis: a potential target for the treatment of Crohn's disease? (English)

1 reference

Europe PubMed Central

PubMed publication ID

9 May 2018

http://europepmc.org/abstract/MED/22157885

1 reference

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inferred from title

Alexander Visekruna

2

1 reference

Europe PubMed Central

PubMed publication ID

9 May 2018

http://europepmc.org/abstract/MED/22157885

Stefan Kaufmann

5

1 reference

Europe PubMed Central

PubMed publication ID

9 May 2018

http://europepmc.org/abstract/MED/22157885

Ulrich Steinhoff

object named as

U Steinhoff

6

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author name string

M Lawrenz

1

1 reference

Europe PubMed Central

PubMed publication ID

9 May 2018

http://europepmc.org/abstract/MED/22157885

A Kühl

3

1 reference

Europe PubMed Central

PubMed publication ID

9 May 2018

http://europepmc.org/abstract/MED/22157885

N Schmidt

4

1 reference

Europe PubMed Central

PubMed publication ID

9 May 2018

http://europepmc.org/abstract/MED/22157885

publication date

7 December 2011

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Europe PubMed Central

PubMed publication ID

9 May 2018

http://europepmc.org/abstract/MED/22157885

Mucosal Immunology

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Europe PubMed Central

PubMed publication ID

9 May 2018

http://europepmc.org/abstract/MED/22157885

5

1 reference

Europe PubMed Central

PubMed publication ID

9 May 2018

http://europepmc.org/abstract/MED/22157885

2

1 reference

Europe PubMed Central

PubMed publication ID

9 May 2018

http://europepmc.org/abstract/MED/22157885

129-139

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Europe PubMed Central

PubMed publication ID

9 May 2018

http://europepmc.org/abstract/MED/22157885

https://scigraph.springernature.com/pub.10.1038/mi.2011.57

0 references

The immunological and genetic basis of inflammatory bowel disease

1 reference

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The genetics and immunopathogenesis of inflammatory bowel disease

1 reference

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Inflammatory Bowel Disease

1 reference

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Inflammatory bowel disease

1 reference

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NF-kappaB1 p105 negatively regulates TPL-2 MEK kinase activity

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TNF-alpha induction by LPS is regulated posttranscriptionally via a Tpl2/ERK-dependent pathway

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TPL2-mediated activation of ERK1 and ERK2 regulates the processing of pre-TNF in LPS-stimulated macrophages

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Activation of mitochondrial ERK protects cancer cells from death through inhibition of the permeability transition

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Innate immune mechanisms of colitis and colitis-associated colorectal cancer

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Proteasome-mediated degradation of IkappaBalpha and processing of p105 in Crohn disease and ulcerative colitis

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Genetic dissection of the cellular pathways and signaling mechanisms in modeled tumor necrosis factor-induced Crohn's-like inflammatory bowel disease

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Human intestinal macrophages display profound inflammatory anergy despite avid phagocytic and bacteriocidal activity

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Common variants in the NLRP3 region contribute to Crohn's disease susceptibility

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The Nlrp3 inflammasome: contributions to intestinal homeostasis

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NF-kappaB1/p105 regulates lipopolysaccharide-stimulated MAP kinase signaling by governing the stability and function of the Tpl2 kinase

1 reference

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Constitutive intestinal NF-κB does not trigger destructive inflammation unless accompanied by MAPK activation

1 reference

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Regulation and function of TPL-2, an IκB kinase-regulated MAP kinase kinase kinase

1 reference

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Tpl2/cot signals activate ERK, JNK, and NF-kappaB in a cell-type and stimulus-specific manner.

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Targeting protein kinases for the development of anti-inflammatory drugs

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Pharmacologic inhibition of tpl2 blocks inflammatory responses in primary human monocytes, synoviocytes, and blood.

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Inhibition of Tpl2 kinase and TNFalpha production with quinoline-3-carbonitriles for the treatment of rheumatoid arthritis.

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Tumour necrosis factor α and interleukin 1β in relapse of Crohn's disease

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Local administration of antisense phosphorothioate oligonucleotides to the p65 subunit of NF-kappa B abrogates established experimental colitis in mice

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Identifiers

10.1038/MI.2011.57

1 reference

Europe PubMed Central

PubMed publication ID

9 May 2018

http://europepmc.org/abstract/MED/22157885

Dimensions Publication ID

0 references

PubMed publication ID

1 reference

Europe PubMed Central

PubMed publication ID

9 May 2018

http://europepmc.org/abstract/MED/22157885

ResearchGate publication ID

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