Methylation silencing and mutations of the p14ARF and p16INK4a genes in colon cancer (Q40822748)

24 September 2017

Methylation silencing and mutations of the p14ARF and p16INK4a genes in colon cancer (English)

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24 September 2017

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N Burri

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24 September 2017

P Shaw

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24 September 2017

H Bouzourene

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24 September 2017

I Sordat

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B Sordat

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M Gillet

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24 September 2017

D Schorderet

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F T Bosman

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24 September 2017

P Chaubert

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24 September 2017

1 February 2001

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24 September 2017

Laboratory Investigation

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24 September 2017

81

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24 September 2017

217-229

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24 September 2017

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https://scigraph.springernature.com/pub.10.1038/labinvest.3780230

24 September 2017

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cites work

An evaluation of six antibodies for immunohistochemistry of mutant p53 gene product in archival colorectal neoplasms

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https://api.crossref.org/works/10.1038%2FLABINVEST.3780230

Sp1 elements protect a CpG island from de novo methylation

21 January 2018

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https://api.crossref.org/works/10.1038%2FLABINVEST.3780230

High sensitivity mapping of methylated cytosines

21 January 2018

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WAF1, a potential mediator of p53 tumor suppression

21 January 2018

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A genetic model for colorectal tumorigenesis

21 January 2018

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A genomic sequencing protocol that yields a positive display of 5-methylcytosine residues in individual DNA strands

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FLABINVEST.3780230

Mdm2 promotes the rapid degradation of p53

21 January 2018

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https://api.crossref.org/works/10.1038%2FLABINVEST.3780230

Methylation-specific PCR: a novel PCR assay for methylation status of CpG islands

21 January 2018

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https://api.crossref.org/works/10.1038%2FLABINVEST.3780230

A cell cycle regulator potentially involved in genesis of many tumor types

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FLABINVEST.3780230

Functional and physical interactions of the ARF tumor suppressor with p53 and Mdm2

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FLABINVEST.3780230

Tumor suppression at the mouse INK4a locus mediated by the alternative reading frame product p19ARF

21 January 2018

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https://api.crossref.org/works/10.1038%2FLABINVEST.3780230

p19ARF prevents G1 cyclin-dependent kinase activation by interacting with MDM2 and activating p53 in mouse fibroblasts.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FLABINVEST.3780230

DNA methylation differences associated with tumor tissues identified by genome scanning analysis

21 January 2018

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https://api.crossref.org/works/10.1038%2FLABINVEST.3780230

Sp1 sites in the mouse aprt gene promoter are required to prevent methylation of the CpG island

21 January 2018

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5' CpG island methylation is associated with transcriptional silencing of the tumour suppressor p16/CDKN2/MTS1 in human cancers.

21 January 2018

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https://api.crossref.org/works/10.1038%2FLABINVEST.3780230

An N-terminal p14ARF peptide blocks Mdm2-dependent ubiquitination in vitro and can activate p53 in vivo

21 January 2018

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https://api.crossref.org/works/10.1038%2FLABINVEST.3780230

The mdm-2 oncogene product forms a complex with the p53 protein and inhibits p53-mediated transactivation

21 January 2018

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https://api.crossref.org/works/10.1038%2FLABINVEST.3780230

Mutations and altered expression of p16INK4 in human cancer.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FLABINVEST.3780230

The Ink4a tumor suppressor gene product, p19Arf, interacts with MDM2 and neutralizes MDM2's inhibition of p53

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FLABINVEST.3780230

Cancer-associated mutations at the INK4a locus cancel cell cycle arrest by p16INK4a but not by the alternative reading frame protein p19ARF.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FLABINVEST.3780230

Alternative reading frames of the INK4a tumor suppressor gene encode two unrelated proteins capable of inducing cell cycle arrest

21 January 2018

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https://api.crossref.org/works/10.1038%2FLABINVEST.3780230

The human ARF cell cycle regulatory gene promoter is a CpG island which can be silenced by DNA methylation and down-regulated by wild-type p53.

21 January 2018

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A new regulatory motif in cell-cycle control causing specific inhibition of cyclin D/CDK4

21 January 2018

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Role of the INK4a locus in tumor suppression and cell mortality.

21 January 2018

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21 January 2018

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Tumor surveillance via the ARF-p53 pathway.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FLABINVEST.3780230

The alternative product from the human CDKN2A locus, p14(ARF), participates in a regulatory feedback loop with p53 and MDM2.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FLABINVEST.3780230

CpG island methylator phenotype in colorectal cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FLABINVEST.3780230

Cooperative signals governing ARF-mdm2 interaction and nucleolar localization of the complex.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FLABINVEST.3780230

The retinoblastoma protein and cell cycle control

21 January 2018

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https://api.crossref.org/works/10.1038%2FLABINVEST.3780230

Mutations in human ARF exon 2 disrupt its nucleolar localization and impair its ability to block nuclear export of MDM2 and p53

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FLABINVEST.3780230

ARF promotes MDM2 degradation and stabilizes p53: ARF-INK4a locus deletion impairs both the Rb and p53 tumor suppression pathways

21 January 2018

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https://api.crossref.org/works/10.1038%2FLABINVEST.3780230

P16 gene in uncultured tumours

21 January 2018

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https://api.crossref.org/works/10.1038%2FLABINVEST.3780230

Complex methylation patterns analyzed by single-strand conformation polymorphism

21 January 2018

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https://api.crossref.org/works/10.1038%2FLABINVEST.3780230

7 January 2021

Rates of p16 (MTS1) mutations in primary tumors with 9p loss

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https://api.crossref.org/works/10.1038%2FLABINVEST.3780230

7 January 2021

p53 gene point mutations in relation to p53 nuclear protein accumulation in colorectal cancers

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https://api.crossref.org/works/10.1038%2FLABINVEST.3780230

7 January 2021

Signaling to p53: breaking the MDM2-p53 circuit

1 reference

https://api.crossref.org/works/10.1038%2FLABINVEST.3780230

7 January 2021

10.1038/LABINVEST.3780230

Identifiers

DOI

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24 September 2017

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