Cooperative signals governing ARF-mdm2 interaction and nucleolar localization of the complex. (Q39451903)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:10713175%20AND%20SRC:MED&resulttype=core&format=json

4 November 2019

title

Cooperative signals governing ARF-mdm2 interaction and nucleolar localization of the complex (English)

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4 November 2019

6

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4 November 2019

author name string

J D Weber

1

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4 November 2019

M L Kuo

2

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4 November 2019

B Bothner

3

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4 November 2019

E L DiGiammarino

4

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4 November 2019

R W Kriwacki

5

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4 November 2019

C J Sherr

7

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4 November 2019

publication date

1 April 2000

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Molecular and Cellular Biology

4 November 2019

language of work or name

English

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published in

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4 November 2019

volume

20

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4 November 2019

issue

7

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4 November 2019

page(s)

2517-2528

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Identification of a cryptic nucleolar-localization signal in MDM2

4 November 2019

cites work

1 reference

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Nucleolar Arf sequesters Mdm2 and activates p53

12 September 2017

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Disruption of the ARF-Mdm2-p53 tumor suppressor pathway in Myc-induced lymphomagenesis

12 September 2017

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Mutations in human ARF exon 2 disrupt its nucleolar localization and impair its ability to block nuclear export of MDM2 and p53

12 September 2017

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P19(ARF) stabilizes p53 by blocking nucleo-cytoplasmic shuttling of Mdm2

12 September 2017

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MDM2 suppresses p73 function without promoting p73 degradation

12 September 2017

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Nucleocytoplasmic shuttling of oncoprotein Hdm2 is required for Hdm2-mediated degradation of p53

12 September 2017

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A leucine-rich nuclear export signal in the p53 tetramerization domain: regulation of subcellular localization and p53 activity by NES masking

12 September 2017

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The INK4A/ARF locus and its two gene products

12 September 2017

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Association of p19(ARF) with Mdm2 inhibits ubiquitin ligase activity of Mdm2 for tumor suppressor p53.

12 September 2017

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p300/MDM2 complexes participate in MDM2-mediated p53 degradation

12 September 2017

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p19 Arf induces p53-dependent apoptosis during Abelson virus-mediated pre-B cell transformation

12 September 2017

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The complexity of p53 modulation: emerging patterns from divergent signals

12 September 2017

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The alternative product from the human CDKN2A locus, p14(ARF), participates in a regulatory feedback loop with p53 and MDM2.

12 September 2017

1 reference

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E1A signaling to p53 involves the p19ARFtumor suppressor

12 September 2017

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Myc signaling via the ARF tumor suppressor regulates p53-dependent apoptosis and immortalization

12 September 2017

1 reference

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Functional and physical interactions of the ARF tumor suppressor with p53 and Mdm2

12 September 2017

1 reference

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ARF Promotes MDM2 Degradation and Stabilizes p53: ARF-INK4a Locus Deletion Impairs Both the Rb and p53 Tumor Suppression Pathways

12 September 2017

1 reference

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The Ink4a Tumor Suppressor Gene Product, p19Arf, Interacts with MDM2 and Neutralizes MDM2's Inhibition of p53

12 September 2017

1 reference

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Oncoprotein MDM2 is a ubiquitin ligase E3 for tumor suppressor p53

12 September 2017

1 reference

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Nucleo-cytoplasmic shuttling of the hdm2 oncoprotein regulates the levels of the p53 protein via a pathway used by the human immunodeficiency virus rev protein.

12 September 2017

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Tumor suppression at the mouse INK4a locus mediated by the alternative reading frame product p19ARF

12 September 2017

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Regulation of p53 stability by Mdm2

12 September 2017

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Mdm2 promotes the rapid degradation of p53

12 September 2017

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p53, the cellular gatekeeper for growth and division

12 September 2017

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Cancer-associated mutations at the INK4a locus cancel cell cycle arrest by p16INK4a but not by the alternative reading frame protein p19ARF.

12 September 2017

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12 September 2017

p53: puzzle and paradigm

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Distinct domains in ribosomal protein L5 mediate 5 S rRNA binding and nucleolar localization

12 September 2017

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Nuclear and nucleolar targeting of human ribosomal protein S6

12 September 2017

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Alternative reading frames of the INK4a tumor suppressor gene encode two unrelated proteins capable of inducing cell cycle arrest

12 September 2017

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Oncoprotein MDM2 conceals the activation domain of tumour suppressor p53

12 September 2017

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The ribosomal L5 protein is associated with mdm-2 and mdm-2-p53 complexes

12 September 2017

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12 September 2017

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12 September 2017

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12 September 2017

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cDNA and deduced primary structure of rat protein B23, a nucleolar protein containing highly conserved sequences

12 September 2017

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Identification of sequences important in the nucleolar localization of human immunodeficiency virus Rev: relevance of nucleolar localization to function

12 September 2017

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BCR first exon sequences specifically activate the BCR/ABL tyrosine kinase oncogene of Philadelphia chromosome-positive human leukemias

12 September 2017

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Mice deficient for p53 are developmentally normal but susceptible to spontaneous tumours

12 September 2017

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The mdm-2 oncogene product forms a complex with the p53 protein and inhibits p53-mediated transactivation

12 September 2017

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Nuclear export is required for degradation of endogenous p53 by MDM2 and human papillomavirus E6

12 September 2017

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Analysis of the degradation function of Mdm2.

14 September 2017

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The primary structure of rat ribosomal protein L5. A comparison of the sequence of amino acids in the proteins that interact with 5 S rRNA.

25 September 2017

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Sequence requirements for nucleolar localization of human T cell leukemia virus type I pX protein, which regulates viral RNA processing

15 June 2018

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Mutant p53 DNA clones from human colon carcinomas cooperate with ras in transforming primary rat cells: a comparison of the "hot spot" mutant phenotypes

15 June 2018

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p14ARF links the tumour suppressors RB and p53

15 June 2018

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17 June 2018

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Tumor surveillance via the ARF–p53 pathway

21 August 2018

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Role of the INK4a locus in tumor suppression and cell mortality

21 August 2018

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p19ARF links the tumour suppressor p53 to Ras

21 August 2018

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p53-deficient mice are extremely susceptible to radiation-induced tumorigenesis

2 December 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/10713175

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Nuclear and nucleolar targeting sequences of c-erb-A, c-myb, N-myc, p53, HSP70, and HIV tat proteins

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/10713175

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Signaling to p53: breaking the MDM2-p53 circuit

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/10713175

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1128/MCB.20.7.2517-2528.2000

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:10713175%20AND%20SRC:MED&resulttype=core&format=json

4 November 2019

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:10713175%20AND%20SRC:MED&resulttype=core&format=json

4 November 2019

PubMed publication ID

10713175

1 reference