Crystallographic structure of a small molecule SIRT1 activator-enzyme complex (Q40776194)

23 September 2017

Crystallographic structure of a small molecule SIRT1 activator-enzyme complex (English)

1 reference

23 September 2017

1

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14 June 2020

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Huizhen Zhao

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14 June 2020

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April W Case

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14 June 2020

Thomas Considine

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14 June 2020

Jessica E Lee

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Yoshitomo Hamuro

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Yong Jiang

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Sharon M Sweitzer

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Beth Pietrak

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Benjamin Schwartz

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Charles A Blum

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Jeremy S Disch

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Richard Caldwell

14

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Bruce Szczepankiewicz

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Christopher Oalmann

16

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Brian H White

18

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Francis Bourbonais

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Bo Wu

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Junfeng Wang

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Dongming Qian

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Fan Jiang

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Cheney Mao

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Minghui Wang

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Erding Hu

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Joe C Wu

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Robert B Perni

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George P Vlasuk

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James L Ellis

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14 June 2020

language of work or name

English

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publication date

2 July 2015

1 reference

23 September 2017

Nature Communications

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14 June 2020

volume

6

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14 June 2020

page(s)

7645

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Creative Commons Attribution 4.0 International

14 June 2020

copyright license

start time

2 July 2015

1 reference

April 2022 Public Data File from Crossref

copyright status

copyrighted

0 references

exact match

https://scigraph.springernature.com/pub.10.1038/ncomms8645

0 references

cites work

Structural and Functional Analysis of Human SIRT1

1 reference

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Discovery of thieno[3,2-d]pyrimidine-6-carboxamides as potent inhibitors of SIRT1, SIRT2, and SIRT3

24 September 2017

1 reference

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Molecular architecture of the human protein deacetylase Sirt1 and its regulation by AROS and resveratrol

24 September 2017

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Evidence for a common mechanism of SIRT1 regulation by allosteric activators

24 September 2017

1 reference

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The 2.5 Å crystal structure of the SIRT1 catalytic domain bound to nicotinamide adenine dinucleotide (NAD+) and an indole (EX527 analogue) reveals a novel mechanism of histone deacetylase inhibition

24 September 2017

1 reference

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Structural basis for allosteric stimulation of Sir2 activity by Sir4 binding

24 September 2017

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From sirtuin biology to human diseases: an update

24 September 2017

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24 September 2017

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Synthesis of carba-NAD and the structures of its ternary complexes with SIRT3 and SIRT5

24 September 2017

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24 September 2017

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SIRT1 contains N- and C-terminal regions that potentiate deacetylase activity

24 September 2017

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Peptide switch is essential for Sirt1 deacetylase activity

24 September 2017

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Sirtuin regulation of mitochondria: energy production, apoptosis, and signaling

24 September 2017

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SIRT1 activation by small molecules: kinetic and biophysical evidence for direct interaction of enzyme and activator

24 September 2017

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24 September 2017

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SRT1720, SRT2183, SRT1460, and resveratrol are not direct activators of SIRT1

24 September 2017

1 reference

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SIRT1 inhibits inflammatory pathways in macrophages and modulates insulin sensitivity

24 September 2017

1 reference

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Structural basis for sirtuin function: what we know and what we don't

24 September 2017

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Recent progress in the biology and physiology of sirtuins

24 September 2017

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A continuous microplate assay for sirtuins and nicotinamide-producing enzymes

24 September 2017

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Crystal structures of human SIRT3 displaying substrate-induced conformational changes

24 September 2017

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24 September 2017

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Discovery of imidazo[1,2-b]thiazole derivatives as novel SIRT1 activators

24 September 2017

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SIRT1 exerts anti-inflammatory effects and improves insulin sensitivity in adipocytes

24 September 2017

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SirT1 gain of function increases energy efficiency and prevents diabetes in mice

24 September 2017

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Small molecule activators of SIRT1 as therapeutics for the treatment of type 2 diabetes

24 September 2017

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SIRT1 deacetylase protects against neurodegeneration in models for Alzheimer's disease and amyotrophic lateral sclerosis

24 September 2017

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24 September 2017

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24 September 2017

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24 September 2017

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24 September 2017

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24 September 2017

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24 September 2017

https://api.crossref.org/works/10.1038%2FNCOMMS8645

Phylogenetic classification of prokaryotic and eukaryotic Sir2-like proteins

21 January 2018

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24 September 2017

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24 September 2017

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19 August 2018

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Crossref

https://api.crossref.org/works/10.1038%2FNCOMMS8645

inferred from DOI database lookup

7 January 2021

based on heuristic

Identifiers

DOI

10.1038/NCOMMS8645

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26134520%20AND%20SRC:MED&resulttype=core&format=json

Dimensions Publication ID

14 June 2020

ADS bibcode

2015NatCo...6.7645D

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0 references

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14 June 2020

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