Optimizing the stability of single-chain proteins by linker length and composition mutagenesis (Q32062853)

6 July 2017

Optimizing the stability of single-chain proteins by linker length and composition mutagenesis (English)

1 reference

6 July 2017

C R Robinson

1

1 reference

PubMed ID

9600894

6 July 2017

R T Sauer

series ordinal

2

1 reference

PubMed ID

9600894

6 July 2017

language of work or name

English

0 references

publication date

1 May 1998

1 reference

Proceedings of the National Academy of Sciences of the United States of America

6 July 2017

1 reference

6 July 2017

95

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6 July 2017

11

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6 July 2017

5929-5934

1 reference

An inverse correlation between loop length and stability in a four-helix-bundle protein.

6 July 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=34497

The linker region of AraC protein

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=34497

Equilibrium stability and sub-millisecond refolding of a designed single-chain Arc repressor.

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=34497

Probing the structure of the linker connecting the reductase and heme domains of cytochrome P450BM-3 using site-directed mutagenesis

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=34497

Selection of linkers for a catalytic single-chain antibody using phage display technology

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=34497

Selection of an active single chain Fv antibody from a protein linker library prepared by enzymatic inverse PCR.

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=34497

Medical applications of single-chain antibodies

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=34497

Genetic fusion of subunits of a dimeric protein substantially enhances its stability and rate of folding

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=34497

P22 Arc repressor: enhanced expression of unstable mutants by addition of polar C-terminal sequences

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=34497

Construction, expression, and activity of a bivalent bispecific single-chain antibody.

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=34497

DNA recognition by beta-sheets in the Arc repressor-operator crystal structure

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=34497

Crystal structure of a diabody, a bivalent antibody fragment

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=34497

Production and structure of diabodies

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=34497

Redesigning the topology of a four-helix-bundle protein: monomeric Rop.

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=34497

Conformation of Polypeptides and Proteins

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=34497

Identifying determinants of folding and activity for a protein of unknown structure

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=34497

Redesigning a sweet protein: increased stability and renaturability

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=34497

Genetically engineered polymers of human CuZn superoxide dismutase. Biochemistry and serum half-lives

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=34497

Structure of Arc repressor in solution: evidence for a family of beta-sheet DNA-binding proteins.

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=34497

A range of catalytic efficiencies with avian retroviral protease subunits genetically linked to form single polypeptide chains

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=34497

Angiogenin single-chain immunofusions: influence of peptide linkers and spacers between fusion protein domains.

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=34497

Covalent attachment of Arc repressor subunits by a peptide linker enhances affinity for operator DNA.

31 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=34497

Construction, characterization, and selected site-specific mutagenesis of an anti-single-stranded DNA single-chain autoantibody.

31 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=34497

An improved linker for single-chain Fv with reduced aggregation and enhanced proteolytic stability.

31 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=34497

Internal structural features of E. coli glycyl-tRNA synthetase examined by subunit polypeptide chain fusions.

31 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=34497

Single-chain Fv fragments of anti-neuraminidase antibody NC10 containing five- and ten-residue linkers form dimers and with zero-residue linker a trimer

31 October 2018

1 reference

12 December 2020

Conformational stability, folding, and ligand-binding affinity of single-chain Fv immunoglobulin fragments expressed in Escherichia coli

1 reference

12 December 2020

Mechanism of specificity in the Fos-Jun oncoprotein heterodimer

1 reference

12 December 2020

Single-chain antigen-binding proteins

1 reference

12 December 2020

Structure-based design of transcription factors

1 reference

12 December 2020

Bioactive murine and human interleukin-12 fusion proteins which retain antitumor activity in vivo

1 reference

12 December 2020

Redesigned anti-human placental alkaline phosphatase single-chain Fv: soluble expression, characterization and in vivo tumour targeting

1 reference

12 December 2020

Identifiers

DOI

10.1073/PNAS.95.11.5929

1 reference

release_jsykwrihhvgjjai3dy7mmnaree

6 July 2017

0 references

1 reference

Fatcat

https://api.fatcat.wiki/v0/release/jsykwrihhvgjjai3dy7mmnaree

24 November 2022

mapped directly with Wikidata item

PMCID

34497

1 reference

6 July 2017

1 reference

PubMed ID

9600894