Spatial sequestration and detoxification of Huntingtin by the ribosome quality control complex. (Q39873468)

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31 March 2020

title

Spatial sequestration and detoxification of Huntingtin by the ribosome quality control complex (English)

1 reference

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31 March 2020

0 references

1

1 reference

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31 March 2020

Beidong Liu

4

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31 March 2020

Thomas Nyström

5

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31 March 2020

author name string

Xinxin Hao

2

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31 March 2020

Xiuling Cao

3

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31 March 2020

language of work or name

English

0 references

publication date

1 April 2016

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31 March 2020

1 reference

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31 March 2020

volume

5

1 reference

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Structure and assembly pathway of the ribosome quality control complex

31 March 2020

cites work

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Prion-like proteins sequester and suppress the toxicity of huntingtin exon 1.

22 September 2017

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22 September 2017

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22 September 2017

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Polyglutamine-rich suppressors of huntingtin toxicity act upstream of Hsp70 and Sti1 in spatial quality control of amyloid-like proteins

22 September 2017

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22 September 2017

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22 September 2017

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A ribosome-bound quality control complex triggers degradation of nascent peptides and signals translation stress

22 September 2017

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22 September 2017

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Role of a ribosome-associated E3 ubiquitin ligase in protein quality control

22 September 2017

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22 September 2017

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22 September 2017

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A mouse forward genetics screen identifies LISTERIN as an E3 ubiquitin ligase involved in neurodegeneration

22 September 2017

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Misfolded proteins partition between two distinct quality control compartments

22 September 2017

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22 September 2017

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Critical role of the proline-rich region in Huntingtin for aggregation and cytotoxicity in yeast.

22 September 2017

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Genome-wide analysis reveals new roles for the activation domains of the Saccharomyces cerevisiae heat shock transcription factor (Hsf1) during the transient heat shock response

22 September 2017

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Flanking sequences profoundly alter polyglutamine toxicity in yeast

22 September 2017

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Active HSF1 significantly suppresses polyglutamine aggregate formation in cellular and mouse models

22 September 2017

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Inclusion body formation reduces levels of mutant huntingtin and the risk of neuronal death

22 September 2017

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22 September 2017

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22 September 2017

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22 September 2017

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22 September 2017

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22 September 2017

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22 September 2017

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Huntington toxicity in yeast model depends on polyglutamine aggregation mediated by a prion-like protein Rnq1

22 September 2017

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22 September 2017

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Hsp70 and hsp40 chaperones can inhibit self-assembly of polyglutamine proteins into amyloid-like fibrils

22 September 2017

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Aggregation of huntingtin in yeast varies with the length of the polyglutamine expansion and the expression of chaperone proteins

22 September 2017

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22 September 2017

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The Src homology domain 3 (SH3) of a yeast type I myosin, Myo5p, binds to verprolin and is required for targeting to sites of actin polarization

22 September 2017

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Extrachromosomal rDNA circles--a cause of aging in yeast

22 September 2017

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Formation of neuronal intranuclear inclusions underlies the neurological dysfunction in mice transgenic for the HD mutation

22 September 2017

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Huntingtin is ubiquitinated and interacts with a specific ubiquitin-conjugating enzyme

22 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4868537

A novel gene containing a trinucleotide repeat that is expanded and unstable on Huntington's disease chromosomes.

22 September 2017

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Not4-dependent translational repression is important for cellular protein homeostasis in yeast

22 September 2017

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Systematic exploration of essential yeast gene function with temperature-sensitive mutants

17 June 2018

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Heat shock response improves heterologous protein secretion in Saccharomyces cerevisiae

17 June 2018

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The polarisome is required for segregation and retrograde transport of protein aggregates.

20 August 2018

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20 August 2018

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Chaperonin TRiC promotes the assembly of polyQ expansion proteins into nontoxic oligomers.

20 August 2018

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20 August 2018

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Life span extension and H(2)O(2) resistance elicited by caloric restriction require the peroxiredoxin Tsa1 in Saccharomyces cerevisiae

20 August 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/27033550

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Metal(loid)s and radionuclides cytotoxicity in Saccharomyces cerevisiae. Role of YCF1, glutathione and effect of buthionine sulfoximine

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/27033550

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Detection of ubiquitylated proteins in yeast

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/27033550

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.7554/ELIFE.11792

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27033550%20AND%20SRC:MED&resulttype=core&format=json

31 March 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27033550%20AND%20SRC:MED&resulttype=core&format=json

31 March 2020

1 reference