Huntingtin is ubiquitinated and interacts with a specific ubiquitin-conjugating enzyme (Q24311567)

ubiquitin-dependent protein catabolic process

GOA release 2020-03-11

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GOA release 2020-03-11

protein ubiquitination

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M A Kalchman

1

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R K Graham

2

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G Xia

3

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H B Koide

4

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J G Hodgson

5

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K C Graham

6

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Y P Goldberg

7

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R D Gietz

8

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C M Pickart

9

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M R Hayden

Journal of Biological Chemistry

10

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language of work or name

English

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publication date

9 August 1996

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published in

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volume

271

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page(s)

19385-94

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issue

32

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cites work

A novel gene containing a trinucleotide repeat that is expanded and unstable on Huntington's disease chromosomes.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.271.32.19385

When more is less: pathogenesis of glutamine repeat neurodegenerative diseases

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.271.32.19385

Huntingtin is a cytoplasmic protein associated with vesicles in human and rat brain neurons

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.271.32.19385

Widespread expression of Huntington's disease gene (IT15) protein product

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.271.32.19385

Evidence from antibody studies that the CAG repeat in the Huntington disease gene is expressed in the protein

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.271.32.19385

Identification and localization of huntingtin in brain and human lymphoblastoid cell lines with anti-fusion protein antibodies

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.271.32.19385

Cellular localization of the Huntington's disease protein and discrimination of the normal and mutated form

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.271.32.19385

Expression analysis of the ataxin-1 protein in tissues from normal and spinocerebellar ataxia type 1 individuals

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.271.32.19385

Abnormal gene product identified in hereditary dentatorubral-pallidoluysian atrophy (DRPLA) brain

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.271.32.19385

CAG expansion affects the expression of mutant Huntingtin in the Huntington's disease brain

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.271.32.19385

Expression of the Huntington's disease (IT15) protein product in HD patients

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.271.32.19385

Somatic and gonadal mosaicism of the Huntington disease gene CAG repeat in brain and sperm.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.271.32.19385

Gametic and somatic tissue-specific heterogeneity of the expanded SCA1 CAG repeat in spinocerebellar ataxia type 1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.271.32.19385

Huntington's disease and repeating trinucleotides

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.271.32.19385

Targeted disruption of the Huntington's disease gene results in embryonic lethality and behavioral and morphological changes in heterozygotes

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.271.32.19385

A novel genetic system to detect protein-protein interactions

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.271.32.19385

The ubiquitin system for protein degradation

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.271.32.19385

The ubiquitin-conjugation system

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.271.32.19385

Induction of ubiquitin-conjugating enzymes during terminal erythroid differentiation

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.271.32.19385

Absence of disease phenotype and intergenerational stability of the CAG repeat in transgenic mice expressing the human Huntington disease transcript

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.271.32.19385

Interaction of the yeast RAD7 and SIR3 proteins: implications for DNA repair and chromatin structure

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.271.32.19385

The p21 Cdk-interacting protein Cip1 is a potent inhibitor of G1 cyclin-dependent kinases

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.271.32.19385

Introducing DNA into Yeast by Transformation

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.271.32.19385

The retinoblastoma protein associates with the protein phosphatase type 1 catalytic subunit

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.271.32.19385

High-resolution mapping of human chromosome 11 by in situ hybridization with cosmid clones

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.271.32.19385

The ubiquitin-proteasome proteolytic pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.271.32.19385

Selective protein degradation: a journey's end within the proteasome

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.271.32.19385

The E6 oncoprotein encoded by human papillomavirus types 16 and 18 promotes the degradation of p53

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.271.32.19385

Ubiquitin-mediated processing of NF-kappa B transcriptional activator precursor p105. Reconstitution of a cell-free system and identification of the ubiquitin-carrier protein, E2, and a novel ubiquitin-protein ligase, E3, involved in conjugation

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.271.32.19385

Role of the ubiquitin-proteasome pathway in regulating abundance of the cyclin-dependent kinase inhibitor p27

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.271.32.19385

Degradation of CFTR by the ubiquitin-proteasome pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.271.32.19385

Coordinated induction of the ubiquitin conjugation pathway accompanies the developmentally programmed death of insect skeletal muscle

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.271.32.19385

Cerebral soluble ubiquitin is increased in patients with Alzheimer's disease.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.271.32.19385

Ubiquitin-reactive neurites in cerebral cortex of subjects with Huntington's chorea: a pathological correlate of dementia?

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.271.32.19385

Protein ubiquitination involving an E1-E2-E3 enzyme ubiquitin thioester cascade

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.271.32.19385

Localization of the E6-AP regions that direct human papillomavirus E6 binding, association with p53, and ubiquitination of associated proteins

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.271.32.19385

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.271.32.19385

Familial Alzheimer's disease in kindreds with missense mutations in a gene on chromosome 1 related to the Alzheimer's disease type 3 gene

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.271.32.19385

Cloning of a gene bearing missense mutations in early-onset familial Alzheimer's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.271.32.19385

A huntingtin-associated protein enriched in brain with implications for pathology

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.271.32.19385

UBC1 encodes a novel member of an essential subfamily of yeast ubiquitin-conjugating enzymes involved in protein degradation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.271.32.19385

7 January 2021

Modes of DAPI banding and simultaneous in situ hybridization

1 reference

https://api.crossref.org/works/10.1074%2FJBC.271.32.19385

7 January 2021

Murine erythroleukemia cells possess an active ubiquitin- and ATP-dependent proteolytic pathway

1 reference

https://api.crossref.org/works/10.1074%2FJBC.271.32.19385

7 January 2021

Isolation of RNA using guanidinium salts

1 reference

https://api.crossref.org/works/10.1074%2FJBC.271.32.19385

7 January 2021

The two-hybrid system: an assay for protein-protein interactions

1 reference

https://api.crossref.org/works/10.1074%2FJBC.271.32.19385

7 January 2021

Ubiquitinated dystrophic neurites suggest corticospinal derangement in patients with amyotrophic lateral sclerosis

1 reference

https://api.crossref.org/works/10.1074%2FJBC.271.32.19385

7 January 2021

Rapid physical mapping of cloned DNA on banded mouse chromosomes by fluorescence in situ hybridization

1 reference

https://api.crossref.org/works/10.1074%2FJBC.271.32.19385

7 January 2021

Make it or break it: the role of ubiquitin-dependent proteolysis in cellular regulation

1 reference

https://api.crossref.org/works/10.1074%2FJBC.271.32.19385

7 January 2021

Dynamic mutations hit double figures

1 reference

https://api.crossref.org/works/10.1074%2FJBC.271.32.19385

7 January 2021

Molecular cloning, expression and characterization of a ubiquitin conjugation enzyme (E2(17)kB) highly expressed in rat testis

1 reference

https://api.crossref.org/works/10.1074%2FJBC.271.32.19385

7 January 2021

Dynamics of ubiquitin conjugation during erythroid differentiation in vitro

1 reference

https://api.crossref.org/works/10.1074%2FJBC.271.32.19385

7 January 2021

Somatic mosaicism of CAG repeat in dentatorubral-pallidoluysian atrophy (DRPLA)

1 reference

https://api.crossref.org/works/10.1074%2FJBC.271.32.19385

7 January 2021

Quantitation and immunocytochemical localization of ubiquitin conjugates within rat red and white skeletal muscles

1 reference

https://api.crossref.org/works/10.1074%2FJBC.271.32.19385

7 January 2021