Tumor suppressor p16INK4a controls oncogenic K-Ras function in human pancreatic cancer cells (Q39448707)

12 September 2017

Tumor suppressor p16INK4a controls oncogenic K-Ras function in human pancreatic cancer cells (English)

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12 September 2017

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Bertram Wiedenmann

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author name string

Anja Rabien

1

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12 September 2017

Hugo Sanchez-Ruderisch

2

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12 September 2017

Petra Schulz

3

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12 September 2017

Noreen Otto

4

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12 September 2017

Anja Wimmel

5

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12 September 2017

Katharina M Detjen

7

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12 September 2017

15 December 2011

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103

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2

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169-175

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Core signaling pathways in human pancreatic cancers revealed by global genomic analyses

12 September 2017

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https://api.crossref.org/works/10.1111%2FJ.1349-7006.2011.02140.X

Pancreatic cancer biology and genetics

21 January 2018

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https://api.crossref.org/works/10.1111%2FJ.1349-7006.2011.02140.X

Precursor lesions in pancreatic cancer: morphological and molecular pathology.

21 January 2018

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https://api.crossref.org/works/10.1111%2FJ.1349-7006.2011.02140.X

The tumor suppressor protein p16INK4a.

21 January 2018

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https://api.crossref.org/works/10.1111%2FJ.1349-7006.2011.02140.X

p16(MTS-1/CDKN2/INK4a) in cancer progression

21 January 2018

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https://api.crossref.org/works/10.1111%2FJ.1349-7006.2011.02140.X

A novel function for the tumor suppressor p16(INK4a): induction of anoikis via upregulation of the alpha(5)beta(1) fibronectin receptor

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1349-7006.2011.02140.X

Stable suppression of tumorigenicity by virus-mediated RNA interference

21 January 2018

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https://api.crossref.org/works/10.1111%2FJ.1349-7006.2011.02140.X

Acquisition of anoikis resistance promotes the emergence of oncogenic K-ras mutations in colorectal cancer cells and stimulates their tumorigenicity in vivo

21 January 2018

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https://api.crossref.org/works/10.1111%2FJ.1349-7006.2011.02140.X

Ras oncogenes: split personalities

21 January 2018

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https://api.crossref.org/works/10.1111%2FJ.1349-7006.2011.02140.X

RAS oncogenes: the first 30 years.

21 January 2018

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https://api.crossref.org/works/10.1111%2FJ.1349-7006.2011.02140.X

The importance of being K-Ras

21 January 2018

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https://api.crossref.org/works/10.1111%2FJ.1349-7006.2011.02140.X

Nonconventional trafficking of Ras associated with Ras signal organization

21 January 2018

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https://api.crossref.org/works/10.1111%2FJ.1349-7006.2011.02140.X

Isoform-specific ras functions in development and cancer

21 January 2018

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https://api.crossref.org/works/10.1111%2FJ.1349-7006.2011.02140.X

Activated Kras and Ink4a/Arf deficiency cooperate to produce metastatic pancreatic ductal adenocarcinoma

21 January 2018

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https://api.crossref.org/works/10.1111%2FJ.1349-7006.2011.02140.X

Induction of senescence by oncogenic Ras.

21 January 2018

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https://api.crossref.org/works/10.1111%2FJ.1349-7006.2011.02140.X

Inhibition of ras-induced proliferation and cellular transformation by p16INK4.

21 January 2018

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https://api.crossref.org/works/10.1111%2FJ.1349-7006.2011.02140.X

Oncogenic ras provokes premature cell senescence associated with accumulation of p53 and p16INK4a

21 January 2018

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https://api.crossref.org/works/10.1111%2FJ.1349-7006.2011.02140.X

Oncogenic K-ras drives cell cycle progression and phenotypic conversion of primary pancreatic duct epithelial cells

21 January 2018

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https://api.crossref.org/works/10.1111%2FJ.1349-7006.2011.02140.X

Tumor induction by an endogenous K-ras oncogene is highly dependent on cellular context

21 January 2018

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https://api.crossref.org/works/10.1111%2FJ.1349-7006.2011.02140.X

Preinvasive and invasive ductal pancreatic cancer and its early detection in the mouse

21 January 2018

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https://api.crossref.org/works/10.1111%2FJ.1349-7006.2011.02140.X

Endogenous oncogenic K-ras(G12D) stimulates proliferation and widespread neoplastic and developmental defects.

21 January 2018

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https://api.crossref.org/works/10.1111%2FJ.1349-7006.2011.02140.X

Genetics and biology of pancreatic ductal adenocarcinoma.

21 January 2018

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https://api.crossref.org/works/10.1111%2FJ.1349-7006.2011.02140.X

Molecular genetics of pancreatic intraepithelial neoplasia

21 January 2018

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https://api.crossref.org/works/10.1111%2FJ.1349-7006.2011.02140.X

Oncogenic KRas suppresses inflammation-associated senescence of pancreatic ductal cells

21 January 2018

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https://api.crossref.org/works/10.1111%2FJ.1349-7006.2011.02140.X

Real-time in vivo imaging of p16Ink4a reveals cross talk with p53.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1349-7006.2011.02140.X

Inducible re-expression of p16 in an orthotopic mouse model of pancreatic cancer inhibits lymphangiogenesis and lymphatic metastasis

21 January 2018

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https://api.crossref.org/works/10.1111%2FJ.1349-7006.2011.02140.X

Direct evidence from siRNA-directed "knock down" that p16(INK4a) is required for human fibroblast senescence and for limiting ras-induced epithelial cell proliferation

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1349-7006.2011.02140.X

Galectin-3 augments K-Ras activation and triggers a Ras signal that attenuates ERK but not phosphoinositide 3-kinase activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1349-7006.2011.02140.X

Galectin-3 regulates a molecular switch from N-Ras to K-Ras usage in human breast carcinoma cells

21 January 2018

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https://api.crossref.org/works/10.1111%2FJ.1349-7006.2011.02140.X

K-ras nanoclustering is subverted by overexpression of the scaffold protein galectin-3.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1349-7006.2011.02140.X

Ankyrin repeat: a unique motif mediating protein-protein interactions.

21 January 2018

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https://api.crossref.org/works/10.1111%2FJ.1349-7006.2011.02140.X

Ras membrane orientation and nanodomain localization generate isoform diversity

21 January 2018

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https://api.crossref.org/works/10.1111%2FJ.1349-7006.2011.02140.X

Nucleophosmin and nucleolin regulate K-Ras plasma membrane interactions and MAPK signal transduction

21 January 2018

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https://api.crossref.org/works/10.1111%2FJ.1349-7006.2011.02140.X

H-Ras is degraded by Wnt/beta-catenin signaling via beta-TrCP-mediated polyubiquitylation

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1349-7006.2011.02140.X

Metabolic turnover of human c-rasH p21 protein of EJ bladder carcinoma and its normal cellular and viral homologs

21 January 2018

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https://api.crossref.org/works/10.1111%2FJ.1349-7006.2011.02140.X

Differential modification of Ras proteins by ubiquitination

21 January 2018

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https://api.crossref.org/works/10.1111%2FJ.1349-7006.2011.02140.X

PKC regulates a farnesyl-electrostatic switch on K-Ras that promotes its association with Bcl-XL on mitochondria and induces apoptosis.

21 January 2018

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https://api.crossref.org/works/10.1111%2FJ.1349-7006.2011.02140.X

Barriers to Ras transformation.

21 January 2018

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https://api.crossref.org/works/10.1111%2FJ.1349-7006.2011.02140.X

Dose-dependent oncogene-induced senescence in vivo and its evasion during mammary tumorigenesis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1349-7006.2011.02140.X

10.1111/J.1349-7006.2011.02140.X

21 January 2018

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12 September 2017

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