Direct evidence from siRNA-directed "knock down" that p16(INK4a) is required for human fibroblast senescence and for limiting ras-induced epithelial cell proliferation (Q24304496)

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English	Direct evidence from siRNA-directed "knock down" that p16(INK4a) is required for human fibroblast senescence and for limiting ras-induced epithelial cell proliferation	scientific article

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17 November 2019

Direct evidence from siRNA-directed "knock down" that p16(INK4a) is required for human fibroblast senescence and for limiting ras-induced epithelial cell proliferation (English)

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17 November 2019

cyclin dependent kinase inhibitor 2A

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GOA release 2020-03-11

replicative senescence

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GOA release 2020-03-11

human fibroblast

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based on heuristic

inferred from title

Christopher J Jones

2

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17 November 2019

author name string

Jane Bond

1

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17 November 2019

Michele Haughton

3

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17 November 2019

Catherine DeMicco

4

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17 November 2019

David Kipling

5

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17 November 2019

David Wynford-Thomas

6

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publication date

1 January 2004

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17 November 2019

Experimental Cell Research

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17 November 2019

292

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17 November 2019

151-156

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17 November 2019

1

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17 November 2019

Origin and progression of thyroid epithelial tumours: cellular and molecular mechanisms

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEXCR.2003.09.021

7 January 2021

Oncogenic ras provokes premature cell senescence associated with accumulation of p53 and p16INK4a

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEXCR.2003.09.021

7 January 2021

Evidence for a telomere-independent "clock" limiting RAS oncogene-driven proliferation of human thyroid epithelial cells

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEXCR.2003.09.021

7 January 2021

Control of replicative life span in human cells: barriers to clonal expansion intermediate between M1 senescence and M2 crisis

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEXCR.2003.09.021

7 January 2021

Immortalisation and transformation revisited

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEXCR.2003.09.021

7 January 2021

Duplexes of 21-nucleotide RNAs mediate RNA interference in cultured mammalian cells

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEXCR.2003.09.021

7 January 2021

Characterisation of human thyroid epithelial cells immortalised in vitro by simian virus 40 DNA transfection

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEXCR.2003.09.021

7 January 2021

Telomerase prevents the accelerated cell ageing of Werner syndrome fibroblasts

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEXCR.2003.09.021

7 January 2021

Differential roles for cyclin-dependent kinase inhibitors p21 and p16 in the mechanisms of senescence and differentiation in human fibroblasts

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEXCR.2003.09.021

7 January 2021

Bypass of senescence after disruption of p21CIP1/WAF1 gene in normal diploid human fibroblasts

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEXCR.2003.09.021

7 January 2021

Sequential extension of proliferative lifespan in human fibroblasts induced by over-expression of CDK4 or 6 and loss of p53 function.

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEXCR.2003.09.021

7 January 2021

INK4a-deficient human diploid fibroblasts are resistant to RAS-induced senescence

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEXCR.2003.09.021

7 January 2021

p16INK4A and p19ARF act in overlapping pathways in cellular immortalization

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEXCR.2003.09.021

7 January 2021

Abolition of cyclin-dependent kinase inhibitor p16Ink4a and p21Cip1/Waf1 functions permits Ras-induced anchorage-independent growth in telomerase-immortalized human fibroblasts

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEXCR.2003.09.021

7 January 2021

Putative telomere-independent mechanisms of replicative aging reflect inadequate growth conditions

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEXCR.2003.09.021

7 January 2021

Frequent inactivation of p16INK4a in oral premalignant lesions

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEXCR.2003.09.021

7 January 2021

Identifiers

10.1016/J.YEXCR.2003.09.021

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Europe PubMed Central

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17 November 2019

1 reference

Europe PubMed Central

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17 November 2019

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