Isoform-specific ras functions in development and cancer (Q37401355)

20 August 2017

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title

Isoform-specific ras functions in development and cancer (English)

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20 August 2017

Margaret P Quinlan

1

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PubMed ID

19243303

20 August 2017

Jeffrey Settleman

series ordinal

2

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PubMed ID

19243303

20 August 2017

language of work or name

English

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publication date

1 February 2009

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20 August 2017

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20 August 2017

5

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20 August 2017

105-116

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20 August 2017

1

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Oncogenic Ras in tumour progression and metastasis

20 August 2017

1 reference

https://api.crossref.org/works/10.2217%2F14796694.5.1.105

RAS oncogenes: the first 30 years.

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14796694.5.1.105

Ras oncogenes and their downstream targets

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14796694.5.1.105

Blocking oncogenic Ras signaling for cancer therapy

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14796694.5.1.105

Targeting RAS signalling pathways in cancer therapy

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14796694.5.1.105

Evolutionary grouping of the RAS-protein family

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14796694.5.1.105

Small GTPases and the evolution of the eukaryotic cell

21 January 2018

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https://api.crossref.org/works/10.2217%2F14796694.5.1.105

Comparative and evolutionary analysis of genes encoding small GTPases and their activating proteins in eukaryotic genomes.

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14796694.5.1.105

Ras proteins in the control of the cell cycle and cell differentiation

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14796694.5.1.105

Ras-effector interactions: after one decade

21 January 2018

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https://api.crossref.org/works/10.2217%2F14796694.5.1.105

Cancer targets in the Ras pathway

21 January 2018

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https://api.crossref.org/works/10.2217%2F14796694.5.1.105

Structure and biological activity of v-raf, a unique oncogene transduced by a retrovirus

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14796694.5.1.105

Roles of the Raf/MEK/ERK pathway in cell growth, malignant transformation and drug resistance

21 January 2018

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https://api.crossref.org/works/10.2217%2F14796694.5.1.105

The importance of being K-Ras

21 January 2018

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https://api.crossref.org/works/10.2217%2F14796694.5.1.105

Mapping the nucleotide and isoform-dependent structural and dynamical features of Ras proteins

21 January 2018

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https://api.crossref.org/works/10.2217%2F14796694.5.1.105

Ras proteins: different signals from different locations

21 January 2018

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https://api.crossref.org/works/10.2217%2F14796694.5.1.105

Palmitoylation and localisation of RAS isoforms are modulated by the hypervariable linker domain.

21 January 2018

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https://api.crossref.org/works/10.2217%2F14796694.5.1.105

Ras signaling from plasma membrane and endomembrane microdomains

21 January 2018

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https://api.crossref.org/works/10.2217%2F14796694.5.1.105

Ras plasma membrane signalling platforms

21 January 2018

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https://api.crossref.org/works/10.2217%2F14796694.5.1.105

Lipid rafts and plasma membrane microorganization: insights from Ras.

21 January 2018

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https://api.crossref.org/works/10.2217%2F14796694.5.1.105

Compartmentalized Ras/MAPK signaling

21 January 2018

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https://api.crossref.org/works/10.2217%2F14796694.5.1.105

Thematic review series: lipid posttranslational modifications. CAAX modification and membrane targeting of Ras.

21 January 2018

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https://api.crossref.org/works/10.2217%2F14796694.5.1.105

Ras signaling on the Golgi

21 January 2018

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https://api.crossref.org/works/10.2217%2F14796694.5.1.105

Compartmentalized signalling of Ras.

21 January 2018

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https://api.crossref.org/works/10.2217%2F14796694.5.1.105

Mapping cellular routes of Ras: a ubiquitin trail.

21 January 2018

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https://api.crossref.org/works/10.2217%2F14796694.5.1.105

Microarray analysis of the differential transformation mediated by Kirsten and Harvey Ras oncogenes in a human colorectal adenocarcinoma cell line.

21 January 2018

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https://api.crossref.org/works/10.2217%2F14796694.5.1.105

A genome-wide survey of RAS transformation targets

21 January 2018

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https://api.crossref.org/works/10.2217%2F14796694.5.1.105

Postprenylation CAAX processing is required for proper localization of Ras but not Rho GTPases

21 January 2018

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https://api.crossref.org/works/10.2217%2F14796694.5.1.105

H-ras but not K-ras traffics to the plasma membrane through the exocytic pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14796694.5.1.105

Endomembrane trafficking of ras: the CAAX motif targets proteins to the ER and Golgi

21 January 2018

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https://api.crossref.org/works/10.2217%2F14796694.5.1.105

Green fluorescent protein-tagged Ras proteins for intracellular localization

21 January 2018

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https://api.crossref.org/works/10.2217%2F14796694.5.1.105

H-Ras dynamically interacts with recycling endosomes in CHO-K1 cells: involvement of Rab5 and Rab11 in the trafficking of H-Ras to this pericentriolar endocytic compartment.

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14796694.5.1.105

Ras diffusion is sensitive to plasma membrane viscosity

21 January 2018

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https://api.crossref.org/works/10.2217%2F14796694.5.1.105

An acylation cycle regulates localization and activity of palmitoylated Ras isoforms

21 January 2018

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https://api.crossref.org/works/10.2217%2F14796694.5.1.105

Ras and its signals diffuse through the cell on randomly moving nanoparticles.

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14796694.5.1.105

Prenylation-dependent association of Ki-Ras with microtubules. Evidence for a role in subcellular trafficking

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14796694.5.1.105

PKC regulates a farnesyl-electrostatic switch on K-Ras that promotes its association with Bcl-XL on mitochondria and induces apoptosis.

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14796694.5.1.105

Reversible intracellular translocation of KRas but not HRas in hippocampal neurons regulated by Ca2+/calmodulin.

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14796694.5.1.105

GTP-dependent segregation of H-ras from lipid rafts is required for biological activity

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14796694.5.1.105

Differential modification of Ras proteins by ubiquitination.

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14796694.5.1.105

Sustained activation of the mitogen-activated protein (MAP) kinase cascade may be required for differentiation of PC12 cells. Comparison of the effects of nerve growth factor and epidermal growth factor

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14796694.5.1.105

Targeted genomic disruption of H-ras and N-ras, individually or in combination, reveals the dispensability of both loci for mouse growth and development

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14796694.5.1.105

K-ras is an essential gene in the mouse with partial functional overlap with N-ras

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14796694.5.1.105

The murine N-ras gene is not essential for growth and development

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14796694.5.1.105

Germline mutations in HRAS proto-oncogene cause Costello syndrome

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14796694.5.1.105

The RAS/MAPK syndromes: novel roles of the RAS pathway in human genetic disorders

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14796694.5.1.105

Stops along the RAS pathway in human genetic disease

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14796694.5.1.105

Genotype-phenotype correlation in Costello syndrome: HRAS mutation analysis in 43 cases.

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14796694.5.1.105

Germline mutations in components of the Ras signaling pathway in Noonan syndrome and related disorders.

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14796694.5.1.105

Phenotypic and genotypic characterisation of Noonan-like/multiple giant cell lesion syndrome

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14796694.5.1.105

Germline KRAS and BRAF mutations in cardio-facio-cutaneous syndrome

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14796694.5.1.105

The cardiofaciocutaneous syndrome

21 January 2018

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https://api.crossref.org/works/10.2217%2F14796694.5.1.105

Germline mutations in genes within the MAPK pathway cause cardio-facio-cutaneous syndrome

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14796694.5.1.105

Germline KRAS mutations cause Noonan syndrome

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14796694.5.1.105

Noonan syndrome and related disorders: genetics and pathogenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14796694.5.1.105

NRAS mutation causes a human autoimmune lymphoproliferative syndrome.

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14796694.5.1.105

Differentiation of 3T3-L1 fibroblasts to adipocytes induced by transfection of ras oncogenes

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14796694.5.1.105

Understanding urothelial carcinoma through cancer pathways

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14796694.5.1.105

Detection of preferential NRAS mutations in human male germ cell tumors by the polymerase chain reaction

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14796694.5.1.105

Oncogenic NRAS rapidly and efficiently induces CMML- and AML-like diseases in mice

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14796694.5.1.105

Activated Kras, but not Hras or Nras, may initiate tumors of endodermal origin via stem cell expansion

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14796694.5.1.105

Explaining the preponderance of Kras mutations in human cancer: An isoform-specific function in stem cell expansion

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14796694.5.1.105

The Ras/Erk pathway induces primitive endoderm but prevents parietal endoderm differentiation of F9 embryonal carcinoma cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14796694.5.1.105

Differentiation of F9 embryonal carcinoma cells induced by the c-jun and activated c-Ha-ras oncogenes

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14796694.5.1.105

Identification of bronchioalveolar stem cells in normal lung and lung cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14796694.5.1.105

Differential effects of oncogenic K-Ras and N-Ras on proliferation, differentiation and tumor progression in the colon

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14796694.5.1.105

Stem cell gene expression changes induced specifically by mutated K-ras.

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14796694.5.1.105

Role of ERas in promoting tumour-like properties in mouse embryonic stem cells

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14796694.5.1.105

Expression of activated M-Ras in hemopoietic stem cells initiates leukemogenic transformation, immortalization and preferential generation of mast cells

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14796694.5.1.105

21 January 2018

Identifiers

DOI

10.2217/14796694.5.1.105

1 reference

20 August 2017

1 reference

PubMed ID

19243303