Voltage-dependent gating of KCNH potassium channels lacking a covalent link between voltage-sensing and pore domains. (Q39372227)

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4 March 2020

title

Voltage-dependent gating of KCNH potassium channels lacking a covalent link between voltage-sensing and pore domains (English)

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4 March 2020

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3

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Jorge Fernández-Trillo

5

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Francisco Barros

8

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4 March 2020

Luis A. Pardo

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4 March 2020

author name string

Éva Lörinczi

1

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4 March 2020

Juan Camilo Gómez-Posada

2

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4 March 2020

Adam P Tomczak

4

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Ulrike Leipscher

6

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Walter Stühmer

7

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language of work or name

English

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publication date

30 March 2015

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4 March 2020

published in

Nature Communications

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volume

6

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page(s)

6672

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Creative Commons Attribution 4.0 International

4 March 2020

copyright license

start time

30 March 2015

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April 2022 Public Data File from Crossref

copyright status

copyrighted

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exact match

https://scigraph.springernature.com/pub.10.1038/ncomms7672

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cites work

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Crystal structure of a mammalian voltage-dependent Shaker family K+ channel

11 September 2017

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11 September 2017

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11 September 2017

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14 September 2017

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14 September 2017

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14 September 2017

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25 September 2017

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Blockade of permeation by potassium but normal gating of the G628S nonconducting hERG channel mutant

17 June 2018

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Kv channel gating requires a compatible S4-S5 linker and bottom part of S6, constrained by non-interacting residues

17 June 2018

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Activation gating of hERG potassium channels: S6 glycines are not required as gating hinges.

17 June 2018

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Mechanism of block of hEag1 K+ channels by imipramine and astemizole

17 June 2018

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The low-potency, voltage-dependent HERG blocker propafenone--molecular determinants and drug trapping.

17 June 2018

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Interactions between S4-S5 linker and S6 transmembrane domain modulate gating of HERG K+ channels

17 June 2018

1 reference

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A quantitative analysis of the activation and inactivation kinetics of HERG expressed in Xenopus oocytes

17 June 2018

1 reference

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Regional flexibility in the S4-S5 linker regulates hERG channel closed-state stabilization

17 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4389246

Participation of HERG channel cytoplasmic structures on regulation by the G protein-coupled TRH receptor.

21 August 2018

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Thermodynamic and kinetic properties of amino-terminal and S4-S5 loop HERG channel mutants under steady-state conditions.

21 August 2018

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Functional interactions at the interface between voltage-sensing and pore domains in the Shaker K(v) channel.

21 August 2018

1 reference

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Structural determinants of M-type KCNQ (Kv7) K+ channel assembly.

21 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4389246

The S4-S5 linker directly couples voltage sensor movement to the activation gate in the human ether-a'-go-go-related gene (hERG) K+ channel.

21 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4389246

Glycosylation of Eag1 (Kv10.1) potassium channels: intracellular trafficking and functional consequences

21 August 2018

1 reference

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Dissociation of E-4031 from the HERG channel caused by mutations of an amino acid results in greater block at high stimulation frequency

21 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4389246

Long QT syndrome-associated mutations in the Per-Arnt-Sim (PAS) domain of HERG potassium channels accelerate channel deactivation.

21 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4389246

Mutations of the S4-S5 linker alter activation properties of HERG potassium channels expressed in Xenopus oocytes.

21 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4389246

Extracellular Mg2+ regulates activation of rat eag potassium channel.

21 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4389246

Different relevance of inactivation and F468 residue in the mechanisms of hEag1 channel blockage by astemizole, imipramine and dofetilide

21 August 2018

1 reference

Crossref

https://api.crossref.org/works/10.1038%2FNCOMMS7672

Blocker protection in the pore of a voltage-gated K+ channel and its structural implications

21 January 2018

1 reference

12 December 2020

Energetics of pore opening in a voltage-gated K(+) channel

1 reference

12 December 2020

Investigation by ion channel domain transplantation of rat glutamate receptor subunits, orphan receptors and a putative NMDA receptor subunit

1 reference

12 December 2020

4'-[(4-Piperidyl)carbonyl]methanesulfonanilides as potent, selective, bioavailable class III antiarrhythmic agents

1 reference

12 December 2020

Identifiers

DOI

10.1038/NCOMMS7672

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25818916%20AND%20SRC:MED&resulttype=core&format=json

4 March 2020

0 references

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25818916%20AND%20SRC:MED&resulttype=core&format=json

4 March 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25818916%20AND%20SRC:MED&resulttype=core&format=json