Regional flexibility in the S4-S5 linker regulates hERG channel closed-state stabilization (Q45841783)

16 December 2017

title

Regional flexibility in the S4-S5 linker regulates hERG channel closed-state stabilization (English)

1 reference

16 December 2017

author

Tom W Claydon

4

1 reference

16 December 2017

author name string

Christina M Hull

1

1 reference

16 December 2017

Stanislav Sokolov

2

1 reference

16 December 2017

Aaron C Van Slyke

3

1 reference

16 December 2017

publication date

10 January 2014

1 reference

16 December 2017

published in

Pfluegers Archiv

1 reference

16 December 2017

volume

466

1 reference

16 December 2017

issue

10

1 reference

16 December 2017

page(s)

1911-1919

1 reference

16 December 2017

https://scigraph.springernature.com/pub.10.1007/s00424-013-1431-9

exact match

0 references

cites work

Dual effect of phosphatidylinositol (4,5)-bisphosphate PIP(2) on Shaker K(+) [corrected] channels

1 reference

https://api.crossref.org/works/10.1007%2FS00424-013-1431-9

Thermodynamic and kinetic properties of amino-terminal and S4-S5 loop HERG channel mutants under steady-state conditions.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00424-013-1431-9

Ion channel voltage sensors: structure, function, and pathophysiology

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00424-013-1431-9

A common pathway for charge transport through voltage-sensing domains

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00424-013-1431-9

Structure of the full-length Shaker potassium channel Kv1.2 by normal-mode-based X-ray crystallographic refinement

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00424-013-1431-9

Functional interactions of voltage sensor charges with an S2 hydrophobic plug in hERG channels

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00424-013-1431-9

Demonstration of physical proximity between the N terminus and the S4-S5 linker of the human ether-a-go-go-related gene (hERG) potassium channel

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00424-013-1431-9

Molecular determinants of interactions between the N-terminal domain and the transmembrane core that modulate hERG K+ channel gating

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00424-013-1431-9

The S4-S5 linker directly couples voltage sensor movement to the activation gate in the human ether-a'-go-go-related gene (hERG) K+ channel.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00424-013-1431-9

Tracking a complete voltage-sensor cycle with metal-ion bridges

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00424-013-1431-9

Kv channel gating requires a compatible S4-S5 linker and bottom part of S6, constrained by non-interacting residues

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00424-013-1431-9

NMR solution structure of the N-terminal domain of hERG and its interaction with the S4-S5 linker

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00424-013-1431-9

Voltage sensor of Kv1.2: structural basis of electromechanical coupling

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00424-013-1431-9

Coupling between voltage sensors and activation gate in voltage-gated K+ channels

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00424-013-1431-9

The S4–S5 Linker Acts as a Signal Integrator for hERG K+ Channel Activation and Deactivation Gating

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00424-013-1431-9

Gating currents associated with intramembrane charge displacement in HERG potassium channels

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00424-013-1431-9

Phosphatidylinositol-4,5-bisphosphate (PIP(2)) stabilizes the open pore conformation of the Kv11.1 (hERG) channel

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00424-013-1431-9

A mechanistic link between an inherited and an acquired cardiac arrhythmia: HERG encodes the IKr potassium channel

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00424-013-1431-9

hERG potassium channels and cardiac arrhythmia

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00424-013-1431-9

Mutations of the S4-S5 linker alter activation properties of HERG potassium channels expressed in Xenopus oocytes.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00424-013-1431-9

Molecular determinants for activation and inactivation of HERG, a human inward rectifier potassium channel.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00424-013-1431-9

Voltage-sensing domain mode shift is coupled to the activation gate by the N-terminal tail of hERG channels

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00424-013-1431-9

A Gating Charge Transfer Center in Voltage Sensors

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00424-013-1431-9

Interactions between S4-S5 linker and S6 transmembrane domain modulate gating of HERG K+ channels

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00424-013-1431-9

HERG, a Human Inward Rectifier in the Voltage-Gated Potassium Channel Family

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00424-013-1431-9

Mutations within the S4-S5 linker alter voltage sensor constraints in hERG K+ channels

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00424-013-1431-9

S4-based voltage sensors have three major conformations

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00424-013-1431-9

Regulation of deactivation by an amino terminal domain in human ether-à-go-go-related gene potassium channels

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00424-013-1431-9

A family of potassium channel genes related to eag in Drosophila and mammals

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00424-013-1431-9

10.1007/S00424-013-1431-9

21 January 2018

Identifiers

DOI

1 reference

16 December 2017

Dimensions Publication ID

0 references

1 reference

16 December 2017