Proline scan of the HERG channel S6 helix reveals the location of the intracellular pore gate. (Q33634079)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24606930%20AND%20SRC:MED&resulttype=core&format=json

9 March 2020

title

Proline scan of the HERG channel S6 helix reveals the location of the intracellular pore gate (English)

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9 March 2020

6

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9 March 2020

author name string

Samrat Thouta

1

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9 March 2020

Stanislav Sokolov

2

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9 March 2020

Yuki Abe

3

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9 March 2020

Sheldon J Clark

4

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9 March 2020

Yen M Cheng

5

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9 March 2020

language of work or name

English

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publication date

1 March 2014

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9 March 2020

number of pages

13

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inferred from page(s)

published in

Biophysical Journal

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9 March 2020

volume

106

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9 March 2020

issue

5

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9 March 2020

page(s)

1057-1069

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Gating charge movement precedes ionic current activation in hERG channels

9 March 2020

cites work

1 reference

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Components of gating charge movement and S4 voltage-sensor exposure during activation of hERG channels

21 June 2018

1 reference

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Voltage-sensing domain mode shift is coupled to the activation gate by the N-terminal tail of hERG channels

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4026777

Mutations within the S4-S5 linker alter voltage sensor constraints in hERG K+ channels

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4026777

Modification of hERG1 channel gating by Cd2+.

21 June 2018

1 reference

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Fluorescence-tracking of activation gating in human ERG channels reveals rapid S4 movement and slow pore opening

21 June 2018

1 reference

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hERG gating microdomains defined by S6 mutagenesis and molecular modeling.

21 June 2018

1 reference

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Crystal structure of a mammalian voltage-dependent Shaker family K+ channel

21 June 2018

1 reference

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The cooperative voltage sensor motion that gates a potassium channel

21 June 2018

1 reference

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Reversed voltage-dependent gating of a bacterial sodium channel with proline substitutions in the S6 transmembrane segment

21 June 2018

1 reference

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Stabilizing the closed S6 gate in the Shaker Kv channel through modification of a hydrophobic seal.

21 June 2018

1 reference

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Gating currents associated with intramembrane charge displacement in HERG potassium channels

21 June 2018

1 reference

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The (beta)gamma subunits of G proteins gate a K(+) channel by pivoted bending of a transmembrane segment

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4026777

Structural and functional role of the extracellular s5-p linker in the HERG potassium channel

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4026777

The open pore conformation of potassium channels

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4026777

Scanning the intracellular S6 activation gate in the shaker K+ channel

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4026777

Fast and slow voltage sensor movements in HERG potassium channels

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4026777

Interactions between S4-S5 linker and S6 transmembrane domain modulate gating of HERG K+ channels

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4026777

Tight steric closure at the intracellular activation gate of a voltage-gated K(+) channel

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4026777

Time course of TEA(+)-induced anomalous rectification in squid giant axons

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4026777

Trapping of a methanesulfonanilide by closure of the HERG potassium channel activation gate.

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4026777

Mutations in the S4 region isolate the final voltage-dependent cooperative step in potassium channel activation

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4026777

Cut-open oocyte voltage-clamp technique

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4026777

The Structure of the Potassium Channel: Molecular Basis of K+ Conduction and Selectivity

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4026777

Uncharged S4 residues and cooperativity in voltage-dependent potassium channel activation

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4026777

Role of the S4 in cooperativity of voltage-dependent potassium channel activation

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4026777

Trapping of organic blockers by closing of voltage-dependent K+ channels: evidence for a trap door mechanism of activation gating.

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4026777

Spectrum of HERG K+-channel dysfunction in an inherited cardiac arrhythmia

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4026777

A molecular basis for cardiac arrhythmia: HERG mutations cause long QT syndrome

21 June 2018

1 reference

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A mechanistic link between an inherited and an acquired cardiac arrhythmia: HERG encodes the IKr potassium channel

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4026777

HERG, a Human Inward Rectifier in the Voltage-Gated Potassium Channel Family

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4026777

Interaction of Tetraethylammonium Ion Derivatives with the Potassium Channels of Giant Axons

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4026777

The inner quaternary ammonium ion receptor in potassium channels of the node of Ranvier

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4026777

Helix geometry in proteins

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4026777

Proline kinks in transmembrane alpha-helices

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4026777

Influence of proline residues on protein conformation

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4026777

The S4-S5 linker directly couples voltage sensor movement to the activation gate in the human ether-a'-go-go-related gene (hERG) K+ channel.

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4026777

Voltage sensor of Kv1.2: structural basis of electromechanical coupling

30 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4026777

Regional specificity of human ether-a'-go-go-related gene channel activation and inactivation gating.

30 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4026777

Physicochemical features of the HERG channel drug binding site

30 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4026777

Structure of the HERG K+ channel S5P extracellular linker: role of an amphipathic alpha-helix in C-type inactivation

30 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4026777

Proline-induced distortions of transmembrane helices.

30 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4026777

Molecular determinants of inactivation and dofetilide block in ether a-go-go (EAG) channels and EAG-related K(+) channels

30 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4026777

Mutations of the S4-S5 linker alter activation properties of HERG potassium channels expressed in Xenopus oocytes.

30 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4026777

Effect of S5P alpha-helix charge mutants on inactivation of hERG K+ channels

30 October 2018

1 reference

12 December 2020

Mapping the sequence of conformational changes underlying selectivity filter gating in the K(v)11.1 potassium channel

1 reference

12 December 2020

Structure-guided topographic mapping and mutagenesis to elucidate binding sites for the human ether-a-go-go-related gene 1 potassium channel (KCNH2) activator NS1643

1 reference

12 December 2020

Gated access to the pore of a voltage-dependent K+ channel

1 reference

12 December 2020

10.1016/J.BPJ.2014.01.035

Identifiers

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24606930%20AND%20SRC:MED&resulttype=core&format=json

9 March 2020

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9 March 2020

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