Enzymatic Halogenation: A Timely Strategy for Regioselective C-H Activation (Q39278644)

10 September 2017

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title

Enzymatic Halogenation: A Timely Strategy for Regioselective C-H Activation (English)

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10 September 2017

1

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28464370%20AND%20SRC:MED&resulttype=core&format=json

8 June 2020

Norbert Sewald

series ordinal

2

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28464370%20AND%20SRC:MED&resulttype=core&format=json

8 June 2020

author name string

Christian Schnepel

series ordinal

1

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10 September 2017

Norbert Sewald

series ordinal

2

1 reference

10 September 2017

language of work or name

English

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publication date

2 May 2017

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Chemistry—A European Journal

10 September 2017

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28464370%20AND%20SRC:MED&resulttype=core&format=json

8 June 2020

volume

23

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28464370%20AND%20SRC:MED&resulttype=core&format=json

8 June 2020

issue

50

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28464370%20AND%20SRC:MED&resulttype=core&format=json

8 June 2020

page(s)

12064-12086

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28464370%20AND%20SRC:MED&resulttype=core&format=json

Industrial biocatalysis today and tomorrow

8 June 2020

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Purification and Partial Characterization of Tryptophan 7-Halogenase (PrnA) from Pseudomonas fluorescens This work was supported by the Deutsche Forschungsgemeinschaft (DFG) through the Graduiertenkolleg "Struktur-Eigenschafts-Beziehungen bei Hetero

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Robust in vitro activity of RebF and RebH, a two-component reductase/halogenase, generating 7-chlorotryptophan during rebeccamycin biosynthesis

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The biosynthetic gene cluster for the antitumor rebeccamycin: characterization and generation of indolocarbazole derivatives

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Enzymatic assembly of the bis-indole core of rebeccamycin

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A regioselective tryptophan 5-halogenase is involved in pyrroindomycin biosynthesis in Streptomyces rugosporus LL-42D005.

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Tandem action of the O2- and FADH2-dependent halogenases KtzQ and KtzR produce 6,7-dichlorotryptophan for kutzneride assembly

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Characterization of a tryptophan 6-halogenase from Streptomyces toxytricini

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Microbisporicin gene cluster reveals unusual features of lantibiotic biosynthesis in actinomycetes

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Two Flavoenzymes Catalyze the Post-Translational Generation of 5-Chlorotryptophan and 2-Aminovinyl-Cysteine during NAI-107 Biosynthesis.

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Structure and biocatalytic scope of thermophilic flavin-dependent halogenase and flavin reductase enzymes

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Crystallization and X-ray diffraction of a halogenating enzyme, tryptophan 7-halogenase, from Pseudomonas fluorescens

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Tryptophan 7-halogenase (PrnA) structure suggests a mechanism for regioselective chlorination

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The structure of flavin-dependent tryptophan 7-halogenase RebH

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Flavin dependent monooxygenases

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Flavin redox chemistry precedes substrate chlorination during the reaction of the flavin-dependent halogenase RebH.

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Chlorination by a long-lived intermediate in the mechanism of flavin-dependent halogenases

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New Insights into the Mechanism of Enzymatic Chlorination of Tryptophan

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Structural Insights into Regioselectivity in the Enzymatic Chlorination of Tryptophan

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A Structure-Guided Switch in the Regioselectivity of a Tryptophan Halogenase

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Structure and action of the myxobacterial chondrochloren halogenase CndH: a new variant of FAD-dependent halogenases

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Chloramphenicol biosynthesis: the structure of CmlS, a flavin-dependent halogenase showing a covalent flavin-aspartate bond

21 January 2018

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Regiospecific chlorination of (S)-beta-tyrosyl-S-carrier protein catalyzed by SgcC3 in the biosynthesis of the enediyne antitumor antibiotic C-1027

21 January 2018

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Molecular and biochemical studies of chondramide formation-highly cytotoxic natural products from Chondromyces crocatus Cm c5.

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Regioselective arene halogenation using the FAD-dependent halogenase RebH.

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Enzyme immobilisation in biocatalysis: why, what and how.

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Enzymatic halogenation of tryptophan on a gram scale

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Integrated catalysis opens new arylation pathways via regiodivergent enzymatic C-H activation.

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Extending the biocatalytic scope of regiocomplementary flavin-dependent halogenase enzymes.

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Understanding Flavin-Dependent Halogenase Reactivity via Substrate Activity Profiling

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Directed Evolution of RebH for Catalyst-Controlled Halogenation of Indole C-H Bonds

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A High-Throughput Fluorescence Assay to Determine the Activity of Tryptophan Halogenases

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Protein stability promotes evolvability

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Use of a halogenase of hormaomycin biosynthesis for formation of new clorobiocin analogues with 5-chloropyrrole moieties

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Engineering fluorometabolite production: fluorinase expression in Salinispora tropica Yields Fluorosalinosporamide.

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Chemistry and biology of monoterpene indole alkaloid biosynthesis

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Directed biosynthesis of alkaloid analogs in the medicinal plant Catharanthus roseus

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Rapid identification of enzyme variants for reengineered alkaloid biosynthesis in periwinkle

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Integrating carbon-halogen bond formation into medicinal plant metabolism.

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Reengineering a tryptophan halogenase to preferentially chlorinate a direct alkaloid precursor

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Combining the 'two worlds' of chemocatalysis and biocatalysis towards multi-step one-pot processes in aqueous media

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Modular chemoenzymatic one-pot syntheses in aqueous media: combination of a palladium-catalyzed cross-coupling with an asymmetric biotransformation

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Late-Stage Diversification of Biologically Active Molecules via Chemoenzymatic C-H Functionalization

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A flavin-dependent tryptophan 6-halogenase and its use in modification of pyrrolnitrin biosynthesis

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Änderung der Regioselektivität der Tryptophan-7-Halogenase PrnA durch ortsspezifische Mutagenese

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Crystal structure of the non-haem iron halogenase SyrB2 in syringomycin biosynthesis

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