Biocatalytic asymmetric synthesis of chiral amines from ketones applied to sitagliptin manufacture (Q34121402)

31 July 2017

Biocatalytic asymmetric synthesis of chiral amines from ketones applied to sitagliptin manufacture (English)

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31 July 2017

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Christopher K Savile

1

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31 July 2017

Jacob M Janey

2

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31 July 2017

Emily C Mundorff

3

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31 July 2017

Jeffrey C Moore

4

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31 July 2017

Sarena Tam

5

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31 July 2017

William R Jarvis

6

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31 July 2017

Jeffrey C Colbeck

7

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31 July 2017

Anke Krebber

8

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31 July 2017

Fred J Fleitz

9

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31 July 2017

Jos Brands

10

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31 July 2017

Paul N Devine

11

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31 July 2017

Gjalt W Huisman

12

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31 July 2017

Gregory J Hughes

13

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31 July 2017

language of work or name

English

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publication date

17 June 2010

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31 July 2017

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31 July 2017

329

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31 July 2017

5989

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31 July 2017

305-309

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Industrial-scale synthesis and applications of asymmetric hydrogenation catalysts

31 July 2017

1 reference

https://api.crossref.org/works/10.1126%2FSCIENCE.1188934

Clinical application of incretin-based therapy: therapeutic potential, patient selection and clinical use.

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCIENCE.1188934

Safety and tolerability of sitagliptin in patients with type 2 diabetes: a pooled analysis

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCIENCE.1188934

Highly efficient asymmetric synthesis of sitagliptin

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCIENCE.1188934

Exploring the active site of amine:pyruvate aminotransferase on the basis of the substrate structure-reactivity relationship: how the enzyme controls substrate specificity and stereoselectivity

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCIENCE.1188934

Redesigning the substrate specificity of omega-aminotransferase for the kinetic resolution of aliphatic chiral amines.

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCIENCE.1188934

Efficient Asymmetric Synthesis of Chiral Amines by Combining Transaminase and Pyruvate Decarboxylase

21 January 2018

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https://api.crossref.org/works/10.1126%2FSCIENCE.1188934

Rapid screening and scale-up of transaminase catalysed reactions

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCIENCE.1188934

Microbial synthesis of chiral amines by (R)-specific transamination with Arthrobacter sp. KNK168.

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCIENCE.1188934

Rapid creation of a novel protein function by in vitro coevolution

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCIENCE.1188934

Looking forward in pharmaceutical process chemistry.

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCIENCE.1188934

Improving catalytic function by ProSAR-driven enzyme evolution

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCIENCE.1188934

Directed evolution of a fucosidase from a galactosidase by DNA shuffling and screening

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCIENCE.1188934

Semi-synthetic DNA shuffling of aveC leads to improved industrial scale production of doramectin by Streptomyces avermitilis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCIENCE.1188934

Engineering proteinase K using machine learning and synthetic genes

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCIENCE.1188934

Rational engineering of enzyme stability

21 January 2018

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https://api.crossref.org/works/10.1126%2FSCIENCE.1188934

Biocatalytic reductions: from lab curiosity to "first choice".

21 January 2018

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https://api.crossref.org/works/10.1126%2FSCIENCE.1188934

Advances in the enzymatic reduction of ketones

21 January 2018

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https://api.crossref.org/works/10.1126%2FSCIENCE.1188934

Practical chiral alcohol manufacture using ketoreductases

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCIENCE.1188934

21 January 2018

Identifiers

DOI

10.1126/SCIENCE.1188934

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31 July 2017

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