Directed Evolution of RebH for Catalyst-Controlled Halogenation of Indole C-H Bonds (Q34532086)

2 August 2017

Directed Evolution of RebH for Catalyst-Controlled Halogenation of Indole C-H Bonds (English)

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2 August 2017

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Mary C Andorfer

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2 August 2017

Hyun June Park

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2

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2 August 2017

Jaylie Vergara-Coll

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2 August 2017

Jared C Lewis

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2 August 2017

19 February 2016

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2 August 2017

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2 August 2017

7

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2 August 2017

6

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2 August 2017

3720-3729

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Total Synthesis of Verruculogen and Fumitremorgin A Enabled by Ligand-Controlled C-H Borylation

2 August 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4917012

Directed evolution of RebH for site-selective halogenation of large biologically active molecules

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4917012

De novo production of the plant-derived alkaloid strictosidine in yeast

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4917012

Enzymatic halogenation of tryptophan on a gram scale

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4917012

Overcoming the limitations of directed C-H functionalizations of heterocycles

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4917012

Improving physical properties via C-H oxidation: chemical and enzymatic approaches

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4917012

Improving the Stability and Catalyst Lifetime of the Halogenase RebH By Directed Evolution

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4917012

Radical-based regioselective C-H functionalization of electron-deficient heteroarenes: scope, tunability, and predictability

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4917012

Regioselective arene halogenation using the FAD-dependent halogenase RebH.

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4917012

Combinatorial evolution of site- and enantioselective catalysts for polyene epoxidation

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4917012

Catalytic selective synthesis

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4917012

Beyond directing groups: transition-metal-catalyzed C-H activation of simple arenes

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4917012

Activation of remote meta-C-H bonds assisted by an end-on template

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4917012

C-H activation: a complementary tool in the total synthesis of complex natural products

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4917012

Engineering the third wave of biocatalysis

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4917012

Weak coordination as a powerful means for developing broadly useful C-H functionalization reactions

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4917012

Reengineering a tryptophan halogenase to preferentially chlorinate a direct alkaloid precursor

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4917012

LigPlot+: multiple ligand-protein interaction diagrams for drug discovery

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4917012

Changing the regioselectivity of the tryptophan 7-halogenase PrnA by site-directed mutagenesis

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4917012

Guiding principles for site selective and stereoselective intermolecular C-H functionalization by donor/acceptor rhodium carbenes.

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4917012

Palladium-catalyzed indole, pyrrole, and furan arylation by aryl chlorides

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4917012

Enzymatic functionalization of carbon-hydrogen bonds

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4917012

Attractive noncovalent interactions in asymmetric catalysis: links between enzymes and small molecule catalysts

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4917012

Halogen atoms in the modern medicinal chemistry: hints for the drug design.

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4917012

Palladium-Catalyzed Ligand-Directed C−H Functionalization Reactions

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4917012

Strain release in C-H bond activation?

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4917012

Exploring protein fitness landscapes by directed evolution

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4917012

Chemoenzymatic elaboration of monosaccharides using engineered cytochrome P450BM3 demethylases

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4917012

The unique role of halogen substituents in the design of modern agrochemicals

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4917012

Palladium(II)-catalyzed C-H activation/C-C cross-coupling reactions: versatility and practicality

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4917012

Automated comparative protein structure modeling with SWISS-MODEL and Swiss-PdbViewer: a historical perspective.

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4917012

Structural Insights into Regioselectivity in the Enzymatic Chlorination of Tryptophan

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4917012

AutoDock Vina: Improving the speed and accuracy of docking with a new scoring function, efficient optimization, and multithreading

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4917012

Rhodium-catalyzed C-C bond formation via heteroatom-directed C-H bond activation

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4917012

New Insights into the Mechanism of Enzymatic Chlorination of Tryptophan

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4917012

Direct functionalization of nitrogen heterocycles via Rh-catalyzed C-H bond activation

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4917012

The structure of flavin-dependent tryptophan 7-halogenase RebH

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4917012

Chlorination by a long-lived intermediate in the mechanism of flavin-dependent halogenases

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4917012

Flavin-dependent halogenases involved in secondary metabolism in bacteria

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4917012

Tryptophan 7-halogenase (PrnA) structure suggests a mechanism for regioselective chlorination

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4917012

Robust in vitro activity of RebF and RebH, a two-component reductase/halogenase, generating 7-chlorotryptophan during rebeccamycin biosynthesis

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4917012

Organometallic chemistry: C-H activation.

7 July 2018

1 reference

https://api.crossref.org/works/10.1039%2FC5SC04680G

Borylation and silylation of C-H bonds: a platform for diverse C-H bond functionalizations

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC5SC04680G

Catalyst-controlled aliphatic C-H oxidations with a predictive model for site-selectivity

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC5SC04680G

Tuning P450 Enzymes as Oxidation Catalysts

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC5SC04680G

Controlling the regiospecific oxidation of aromatics via active site engineering of toluene para-monooxygenase of Ralstonia pickettii PKO1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC5SC04680G

Extending the biocatalytic scope of regiocomplementary flavin-dependent halogenase enzymes.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC5SC04680G

Iridium-catalyzed, silyl-directed borylation of nitrogen-containing heterocycles

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC5SC04680G

Pd(II)-catalyzed meta-C-H olefination, arylation, and acetoxylation of indolines using a U-shaped template.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC5SC04680G

Gene expression enabling synthetic diversification of natural products: chemogenetic generation of pacidamycin analogs

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC5SC04680G

A new tool to guide halofunctionalization reactions: the halenium affinity (HalA) scale.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC5SC04680G

Ruthenium(II)-catalyzed C-H bond activation and functionalization

21 January 2018

1 reference

12 December 2020

A practical Lewis base catalyzed electrophilic chlorination of arenes and heterocycles

1 reference

12 December 2020

Efficient activation of aromatic C-H bonds for addition to C-C multiple bonds

1 reference

12 December 2020

Molecular recognition in the selective oxygenation of saturated C-H bonds by a dimanganese catalyst

1 reference

12 December 2020

Catalytic oxidations of steroid substrates by artificial cytochrome p-450 enzymes

1 reference

12 December 2020

Diversification of monoterpene indole alkaloid analogs through cross-coupling

1 reference

12 December 2020

Ir-catalyzed functionalization of 2-substituted indoles at the 7-position: nitrogen-directed aromatic borylation

1 reference

12 December 2020

Carboxylate-assisted transition-metal-catalyzed C-H bond functionalizations: mechanism and scope

1 reference

12 December 2020

High-throughput method for determining the enantioselectivity of enzyme-catalyzed hydroxylations based on mass spectrometry

1 reference

12 December 2020

Identifiers

DOI

10.1039/C5SC04680G

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2 August 2017

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2 August 2017

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