Directed evolution of RebH for site-selective halogenation of large biologically active molecules (Q34462524)

2 August 2017

Directed evolution of RebH for site-selective halogenation of large biologically active molecules (English)

1 reference

2 August 2017

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James T Payne

1

1 reference

2 August 2017

Catherine B Poor

series ordinal

2

1 reference

2 August 2017

Jared C Lewis

series ordinal

3

1 reference

2 August 2017

language of work or name

English

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publication date

9 February 2015

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Angewandte Chemie International Edition

2 August 2017

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volume

54

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2 August 2017

14

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2 August 2017

4226-4230

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Enzymatic halogenation of tryptophan on a gram scale

2 August 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4506780

Improving the Stability and Catalyst Lifetime of the Halogenase RebH By Directed Evolution

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4506780

Synthesis and antiviral and fungicidal activity evaluation of β-carboline, dihydro-β-carboline, tetrahydro-β-carboline alkaloids, and their derivatives

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4506780

Regioselective arene halogenation using the FAD-dependent halogenase RebH.

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4506780

Intercepting bacterial indole signaling with flustramine derivatives

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4506780

Reengineering a tryptophan halogenase to preferentially chlorinate a direct alkaloid precursor

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4506780

Changing the regioselectivity of the tryptophan 7-halogenase PrnA by site-directed mutagenesis

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4506780

Combinatorial alanine substitution enables rapid optimization of cytochrome P450BM3 for selective hydroxylation of large substrates

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4506780

Integrating carbon-halogen bond formation into medicinal plant metabolism.

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4506780

Biocatalytic asymmetric synthesis of chiral amines from ketones applied to sitagliptin manufacture

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4506780

Halogen atoms in the modern medicinal chemistry: hints for the drug design.

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4506780

Exploring protein fitness landscapes by directed evolution

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4506780

The unique role of halogen substituents in the design of modern agrochemicals

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4506780

Carvedilol in hypertension treatment

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4506780

Evolutionary history of a specialized p450 propane monooxygenase

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4506780

Discovery and structure-activity relationship of (1R)-8-chloro-2,3,4,5-tetrahydro-1-methyl-1H-3-benzazepine (Lorcaserin), a selective serotonin 5-HT2C receptor agonist for the treatment of obesity

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4506780

The structure of flavin-dependent tryptophan 7-halogenase RebH

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4506780

Gene splicing and mutagenesis by PCR-driven overlap extension

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4506780

Tryptophan 7-halogenase (PrnA) structure suggests a mechanism for regioselective chlorination

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4506780

New cytotoxic salinosporamides from the marine Actinomycete Salinispora tropica

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4506780

Robust in vitro activity of RebF and RebH, a two-component reductase/halogenase, generating 7-chlorotryptophan during rebeccamycin biosynthesis

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4506780

Combinatorial biosynthesis of antitumor indolocarbazole compounds

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4506780

Yohimbine: a clinical review

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4506780

Capsaicin-like anti-obese activities of evodiamine from fruits of Evodia rutaecarpa, a vanilloid receptor agonist

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4506780

A structural view of evolutionary divergence

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4506780

Behavioural effects of pinoline in the rat forced swimming, open field and elevated plus-maze tests.

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4506780

Pindolol-a beta-adrenoceptor blocking drug with partial agonist activity: clinical pharmacological considerations

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4506780

Carazolol, an extremely potent β-adrenergic blocker: Binding to β-receptors in brain membranes

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4506780

Systematic and pairwise analysis of the effects of aromatic halogenation and trifluoromethyl substitution on human liver microsomal clearance

6 July 2018

1 reference

https://api.crossref.org/works/10.1002%2FANIE.201411901

Gene expression enabling synthetic diversification of natural products: chemogenetic generation of pacidamycin analogs

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FANIE.201411901

Demonstration of the importance and usefulness of manipulating non-active-site residues in protein design

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FANIE.201411901

Engineered alkane-hydroxylating cytochrome P450(BM3) exhibiting nativelike catalytic properties

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FANIE.201411901

Änderung der Regioselektivität der Tryptophan-7-Halogenase PrnA durch ortsspezifische Mutagenese

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FANIE.201411901

Expanding the range of substrate acceptance of enzymes: combinatorial active-site saturation test

21 January 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/25678465

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1002/ANIE.201411901

1 reference

2 August 2017

1 reference

2 August 2017

1 reference