Autocrine stimulation of clear-cell renal carcinoma cell migration in hypoxia via HIF-independent suppression of thrombospondin-1. (Q39246000)

10 September 2017

Autocrine stimulation of clear-cell renal carcinoma cell migration in hypoxia via HIF-independent suppression of thrombospondin-1. (English)

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10 September 2017

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Raquel Bienes-Martínez

1

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10 September 2017

Angel Ordóñez

2

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10 September 2017

Mónica Feijoo-Cuaresma

3

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10 September 2017

María Corral-Escariz

4

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10 September 2017

Gloria Mateo

5

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10 September 2017

Olga Stenina

6

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10 September 2017

Benilde Jiménez

7

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10 September 2017

María J Calzada

8

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10 September 2017

language of work or name

English

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publication date

9 November 2012

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10 September 2017

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10 September 2017

2

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10 September 2017

788

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https://scigraph.springernature.com/pub.10.1038/srep00788

10 September 2017

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cites work

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Akt2 regulates all Akt isoforms and promotes resistance to hypoxia through induction of miR-21 upon oxygen deprivation

10 September 2017

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MiR-21 induced angiogenesis through AKT and ERK activation and HIF-1α expression

10 September 2017

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Regulation of thrombospondin-1 expression through AU-rich elements in the 3'UTR of the mRNA.

10 September 2017

1 reference

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Thrombospondin-1 inhibits VEGF receptor-2 signaling by disrupting its association with CD47.

10 September 2017

1 reference

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Hypoxia-regulated angiogenic inhibitors

10 September 2017

1 reference

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Intermittent and sustained hypoxia induce a similar gene expression profile in human aortic endothelial cells

10 September 2017

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The role of HIF prolyl hydroxylases in tumour growth.

10 September 2017

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Hypoxic tumor cell modulates its microenvironment to enhance angiogenic and metastatic potential by secretion of proteins and exosomes

10 September 2017

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Genome-wide identification of hypoxia-inducible factor binding sites and target genes by a probabilistic model integrating transcription-profiling data and in silico binding site prediction

10 September 2017

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Genome-wide association of hypoxia-inducible factor (HIF)-1alpha and HIF-2alpha DNA binding with expression profiling of hypoxia-inducible transcripts

10 September 2017

1 reference

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Thrombospondin 1 promotes tumor macrophage recruitment and enhances tumor cell cytotoxicity of differentiated U937 cells

10 September 2017

1 reference

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Thrombospondin 1 and vasoactive agents indirectly alter tumor blood flow.

10 September 2017

1 reference

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Cell type-specific post-transcriptional regulation of production of the potent antiangiogenic and proatherogenic protein thrombospondin-1 by high glucose

10 September 2017

1 reference

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Hypoxia-inducible factors and cancer.

10 September 2017

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Augmentation of tumor angiogenesis by a Myc-activated microRNA cluster

10 September 2017

1 reference

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Akt1 regulates pathological angiogenesis, vascular maturation and permeability in vivo

10 September 2017

1 reference

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Transcriptional repression of human cad gene by hypoxia inducible factor-1alpha

10 September 2017

1 reference

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The thrombospondin type 1 repeat superfamily

10 September 2017

1 reference

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Id1 regulates angiogenesis through transcriptional repression of thrombospondin-1

10 September 2017

1 reference

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Thrombospondin-1 as an endogenous inhibitor of angiogenesis and tumor growth.

10 September 2017

1 reference

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A conserved family of prolyl-4-hydroxylases that modify HIF

10 September 2017

1 reference

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C. elegans EGL-9 and mammalian homologs define a family of dioxygenases that regulate HIF by prolyl hydroxylation

10 September 2017

1 reference

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HIF-1, O(2), and the 3 PHDs: how animal cells signal hypoxia to the nucleus

10 September 2017

1 reference

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Thrombospondins as matricellular modulators of cell function

10 September 2017

1 reference

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HIFalpha targeted for VHL-mediated destruction by proline hydroxylation: implications for O2 sensing

10 September 2017

1 reference

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Targeting of HIF-alpha to the von Hippel-Lindau ubiquitylation complex by O2-regulated prolyl hydroxylation

10 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3494377

PTEN controls tumor-induced angiogenesis

10 September 2017

1 reference

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Activation of the myc oncoprotein leads to increased turnover of thrombospondin-1 mRNA

10 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3494377

Thrombospondin-1 is downregulated by anoxia and suppresses tumorigenicity of human glioblastoma cells

10 September 2017

1 reference

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The tumour suppressor protein VHL targets hypoxia-inducible factors for oxygen-dependent proteolysis

10 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3494377

SPARC and thrombospondin genes are repressed by the c-jun oncogene in rat embryo fibroblasts.

10 September 2017

1 reference

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Biological activities of peptides and peptide analogues derived from common sequences present in thrombospondin, properdin, and malarial proteins

10 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3494377

A tumor suppressor-dependent inhibitor of angiogenesis is immunologically and functionally indistinguishable from a fragment of thrombospondin

10 September 2017

1 reference

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Suppression of cyclin D1 by hypoxia-inducible factor-1 via direct mechanism inhibits the proliferation and 5-fluorouracil-induced apoptosis of A549 cells

10 September 2017

1 reference

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Transient potential receptor channel 4 controls thrombospondin-1 secretion and angiogenesis in renal cell carcinoma.

14 September 2017

1 reference

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The proangiogenic phenotype of human tumor-derived endothelial cells depends on thrombospondin-1 downregulation via phosphatidylinositol 3-kinase/Akt pathway

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3494377

Ras modulates Myc activity to repress thrombospondin-1 expression and increase tumor angiogenesis

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3494377

Antisense-mediated reduction in thrombospondin reverses the malignant phenotype of a human squamous carcinoma

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3494377

Transformation by v-src causes transient induction followed by repression of mouse thrombospondin-1.

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3494377

Opposing effects of hypoxia on expression of the angiogenic inhibitor thrombospondin 1 and the angiogenic inducer vascular endothelial growth factor.

25 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3494377

The p53 tumor suppressor gene inhibits angiogenesis by stimulating the production of thrombospondin.

17 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3494377

Hypoxia stimulates the autocrine regulation of migration of vascular smooth muscle cells via HIF-1alpha-dependent expression of thrombospondin-1.

17 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3494377

HER2 signaling modulates the equilibrium between pro- and antiangiogenic factors via distinct pathways: implications for HER2-targeted antibody therapy.

21 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3494377

Promoter region methylation and reduced expression of thrombospondin-1 after oxygen-glucose deprivation in murine cerebral endothelial cells.

21 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3494377

Inhibition of Tie-2 signaling induces endothelial cell apoptosis, decreases Akt signaling, and induces endothelial cell expression of the endogenous anti-angiogenic molecule, thrombospondin-1.

21 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3494377

Hypoxia induces the activation of the phosphatidylinositol 3-kinase/Akt cell survival pathway in PC12 cells: protective role in apoptosis

21 August 2018

1 reference

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Methylation and silencing of the Thrombospondin-1 promoter in human cancer.

21 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3494377

21 August 2018

1 reference

https://api.crossref.org/works/10.1038%2FSREP00788

Thrombospondin, a potentiator of tumor cell metastasis

21 January 2018

1 reference

12 December 2020

Hypoxia increases thrombospondin-1 transcript and protein in cultured endothelial cells

1 reference

12 December 2020

Signal transduction of MEK/ERK and PI3K/Akt activation by hypoxia/reoxygenation in renal epithelial cells

1 reference

12 December 2020

Plasma level and tissue expression of vascular endothelial growth factor in renal cell carcinoma: a prospective study of 50 cases

1 reference

12 December 2020

Hypoxia-induced increase in the production of extracellular matrix proteins in systemic sclerosis

1 reference

12 December 2020

The expression of thrombospondin-1 and p53 in clear cell renal cell carcinoma: its relationship to angiogenesis, cell proliferation and cancer specific survival

1 reference

12 December 2020

Identifiers

DOI

10.1038/SREP00788

1 reference

release_fc75con5fvfijmdraaza7dcyoy

10 September 2017

1 reference

Fatcat

https://api.fatcat.wiki/v0/release/fc75con5fvfijmdraaza7dcyoy

24 November 2022

mapped directly with Wikidata item

1 reference

10 September 2017

1 reference