Thrombospondin-1 inhibits VEGF receptor-2 signaling by disrupting its association with CD47. (Q34385843)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20923780%20AND%20SRC:MED&resulttype=core&format=json

15 February 2020

title

Thrombospondin-1 inhibits VEGF receptor-2 signaling by disrupting its association with CD47 (English)

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15 February 2020

6

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15 February 2020

author name string

Sukhbir Kaur

1

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15 February 2020

Gema Martin-Manso

2

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15 February 2020

Michael L Pendrak

3

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15 February 2020

Susan H Garfield

4

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15 February 2020

Jeff S Isenberg

5

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15 February 2020

language of work or name

English

0 references

publication date

5 October 2010

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Journal of Biological Chemistry

15 February 2020

published in

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15 February 2020

volume

285

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15 February 2020

page(s)

38923-38932

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15 February 2020

issue

50

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Thrombospondin-1 supports blood pressure by limiting eNOS activation and endothelial-dependent vasorelaxation

15 February 2020

cites work

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Thrombospondin-1 is a critical effector of oncosuppressive activity of sst2 somatostatin receptor on pancreatic cancer

6 July 2018

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Thrombospondin-1 modulates vascular endothelial growth factor activity at the receptor level

6 July 2018

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Thrombospondin-1 modulates VEGF-A-mediated Akt signaling and capillary survival in the developing retina.

6 July 2018

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Cooperation between integrin alphavbeta3 and VEGFR2 in angiogenesis

6 July 2018

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Regulation of nitric oxide signalling by thrombospondin 1: implications for anti-angiogenic therapies

6 July 2018

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Differential interactions of thrombospondin-1, -2, and -4 with CD47 and effects on cGMP signaling and ischemic injury responses.

6 July 2018

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VEGF inhibition: insights from preclinical and clinical studies

6 July 2018

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Inhibition of vascular endothelial growth factor-a signaling induces hypertension: examining the effect of cediranib (recentin; AZD2171) treatment on blood pressure in rat and the use of concomitant antihypertensive therapy

6 July 2018

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Gene silencing of CD47 and antibody ligation of thrombospondin-1 enhance ischemic tissue survival in a porcine model: implications for human disease

6 July 2018

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Thrombospondin-1: a physiological regulator of nitric oxide signaling

6 July 2018

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Blockade of thrombospondin-1-CD47 interactions prevents necrosis of full thickness skin grafts

6 July 2018

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Thrombospondin-1 stimulates platelet aggregation by blocking the antithrombotic activity of nitric oxide/cGMP signaling

6 July 2018

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Autocrine VEGF signaling is required for vascular homeostasis

6 July 2018

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Thrombospondin-1 inhibits nitric oxide signaling via CD36 by inhibiting myristic acid uptake

6 July 2018

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Thrombospondin-1 inhibits VEGF levels in the ovary directly by binding and internalization via the low density lipoprotein receptor-related protein-1 (LRP-1).

6 July 2018

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Differential roles of vascular endothelial growth factor receptor-1 and receptor-2 in angiogenesis

6 July 2018

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Vascular endothelial cadherin controls VEGFR-2 internalization and signaling from intracellular compartments

6 July 2018

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CD47 is necessary for inhibition of nitric oxide-stimulated vascular cell responses by thrombospondin-1

6 July 2018

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Thrombospondin-1 inhibits endothelial cell responses to nitric oxide in a cGMP-dependent manner

6 July 2018

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Myristic acid stimulates endothelial nitric-oxide synthase in a CD36- and an AMP kinase-dependent manner

6 July 2018

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Inhibition of endothelial cell migration by thrombospondin-1 type-1 repeats is mediated by beta1 integrins

6 July 2018

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Endogenous angiogenesis inhibitors

6 July 2018

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Crystal structure of the TSP-1 type 1 repeats

6 July 2018

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Role of Akt signaling in vascular homeostasis and angiogenesis

6 July 2018

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Thrombospondin-1 as an endogenous inhibitor of angiogenesis and tumor growth.

6 July 2018

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A single autophosphorylation site on KDR/Flk-1 is essential for VEGF-A-dependent activation of PLC-gamma and DNA synthesis in vascular endothelial cells

6 July 2018

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Integrin-associated protein (CD47) and its ligands

6 July 2018

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Cell contact-dependent activation of alpha3beta1 integrin modulates endothelial cell responses to thrombospondin-1

6 July 2018

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Phosphorylation of the endothelial nitric oxide synthase at ser-1177 is required for VEGF-induced endothelial cell migration

6 July 2018

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Activation of nitric oxide synthase in endothelial cells by Akt-dependent phosphorylation

6 July 2018

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Quantitative fluorescence resonance energy transfer measurements using fluorescence microscopy

6 July 2018

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Nitric oxide production contributes to the angiogenic properties of vascular endothelial growth factor in human endothelial cells

6 July 2018

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CD36 mediates the In vitro inhibitory effects of thrombospondin-1 on endothelial cells

6 July 2018

1 reference

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A tumor suppressor-dependent inhibitor of angiogenesis is immunologically and functionally indistinguishable from a fragment of thrombospondin

6 July 2018

1 reference

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Platelet thrombospondin modulates endothelial cell adhesion, motility, and growth: a potential angiogenesis regulatory factor.

6 July 2018

1 reference

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Dual regulation of vascular endothelial growth factor bioavailability by genetic and proteolytic mechanisms

6 July 2018

1 reference

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Regulation of integrin function by CD47 ligands. Differential effects on alpha vbeta 3 and alpha 4beta1 integrin-mediated adhesion

6 July 2018

1 reference

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Physical characterization of the procollagen module of human thrombospondin 1 expressed in insect cells.

21 January 2018

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Phylogenetic divergence of CD47 interactions with human signal regulatory protein alpha reveals locus of species specificity. Implications for the binding site.

21 January 2018

1 reference

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Extracellular matrix‐bound vascular endothelial growth factor promotes endothelial cell adhesion, migration, and survival through integrin ligation

21 January 2018

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Thrombospondins function as regulators of angiogenesis

21 January 2018

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IQGAP1 mediates VE-cadherin-based cell-cell contacts and VEGF signaling at adherence junctions linked to angiogenesis.

21 January 2018

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Vascular endothelial growth factor induces EDRF-dependent relaxation in coronary arteries

21 January 2018

1 reference

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Integrin-Associated Protein Binding Domain of Thrombospondin-1 Enhances Insulin-Like Growth Factor-I Receptor Signaling in Vascular Smooth Muscle Cells

27 October 2018

1 reference

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Increasing Survival of Ischemic Tissue by Targeting CD47

21 January 2018

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Binding and displacement of vascular endothelial growth factor (VEGF) by thrombospondin: effect on human microvascular endothelial cell proliferation and angiogenesis

21 January 2018

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12 December 2020

Specific inhibition of endothelial cell proliferation by thrombospondin

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12 December 2020

Signals leading to apoptosis-dependent inhibition of neovascularization by thrombospondin-1

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12 December 2020

Alpha4beta1 integrin mediates selective endothelial cell responses to thrombospondins 1 and 2 in vitro and modulates angiogenesis in vivo

1 reference

12 December 2020

Identification of an alpha(3)beta(1) integrin recognition sequence in thrombospondin-1

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12 December 2020

Identifiers

DOI

10.1074/JBC.M110.172304

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20923780%20AND%20SRC:MED&resulttype=core&format=json

15 February 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20923780%20AND%20SRC:MED&resulttype=core&format=json

15 February 2020

1 reference