Ras modulates Myc activity to repress thrombospondin-1 expression and increase tumor angiogenesis (Q40658383)

22 September 2017

14 January 2013

3 references

Dataset for "Continued use of retracted papers: Temporal trends in citations and (lack of) awareness of retractions shown in citation contexts in biomedicine"

Continued use of retracted papers: Temporal trends in citations and (lack of) awareness of retractions shown in citation contexts in biomedicine

19 August 2025

Ras modulates Myc activity to repress thrombospondin-1 expression and increase tumor angiogenesis (English)

1 reference

22 September 2017

1 reference

Randolph S Watnick

1

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22 September 2017

Yi-Ning Cheng

2

1 reference

22 September 2017

Annapoorni Rangarajan

3

1 reference

22 September 2017

Tan A Ince

4

1 reference

22 September 2017

Robert A Weinberg

5

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22 September 2017

publication date

1 March 2003

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22 September 2017

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22 September 2017

volume

3

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22 September 2017

issue

3

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22 September 2017

page(s)

219-231

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Phosphorylation and activation of myosin by Rho-associated kinase (Rho-kinase)

22 September 2017

cites work

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Mice without telomerase: what can they teach us about human cancer?

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Vascular permeability factor (vascular endothelial growth factor) gene is expressed differentially in normal tissues, macrophages, and tumors

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Max: a helix-loop-helix zipper protein that forms a sequence-specific DNA-binding complex with Myc

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Telomerase beyond telomeres

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Extension of life-span by introduction of telomerase into normal human cells

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Antisense-mediated reduction in thrombospondin reverses the malignant phenotype of a human squamous carcinoma

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Molecular mechanisms of tumor angiogenesis and tumor progression

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7 January 2021

Essential role for oncogenic Ras in tumour maintenance

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7 January 2021

Genomic analysis of metastasis reveals an essential role for RhoC

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Inflammatory mast cells up-regulate angiogenesis during squamous epithelial carcinogenesis

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CD36 Mediates the In Vitro Inhibitory Effects of Thrombospondin-1 on Endothelial Cells

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Human breast cancer cells generated by oncogenic transformation of primary mammary epithelial cells.

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Genetic alteration of the c-myc protooncogene (MYC) in human primary breast carcinomas

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Identification of a Novel Inhibitor of Mitogen-activated Protein Kinase Kinase

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The protein kinase encoded by the Akt proto-oncogene is a target of the PDGF-activated phosphatidylinositol 3-kinase

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7 January 2021

A tumor suppressor-dependent inhibitor of angiogenesis is immunologically and functionally indistinguishable from a fragment of thrombospondin

1 reference

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7 January 2021

Transactivation of gene expression by Myc is inhibited by mutation at the phosphorylation sites Thr-58 and Ser-62.

1 reference

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7 January 2021

Creation of human tumour cells with defined genetic elements

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Patterns and emerging mechanisms of the angiogenic switch during tumorigenesis

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The Hallmarks of Cancer

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Transgenic mouse models of tumour angiogenesis: the angiogenic switch, its molecular controls, and prospects for preclinical therapeutic models

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7 January 2021

Dormancy of micrometastases: Balanced proliferation and apoptosis in the presence of angiogenesis suppression

1 reference

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Signal transduction in T lymphocytes using a conditional allele of Sos

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Cooperative and redundant effects of STAT5 and Ras signaling in BCR/ABL transformed hematopoietic cells

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Angiogenin promotes invasiveness of cultured endothelial cells by stimulation of cell-associated proteolytic activities

1 reference

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7 January 2021

Phosphorylation of myosin-binding subunit (MBS) of myosin phosphatase by Rho-kinase in vivo

1 reference

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7 January 2021

Both Rb/p16INK4a inactivation and telomerase activity are required to immortalize human epithelial cells.

1 reference

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7 January 2021

The human c-Kirsten ras gene is activated by a novel mutation in codon 13 in the breast carcinoma cell line MDA-MB231.

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Tumorigenic conversion of primary embryo fibroblasts requires at least two cooperating oncogenes

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Vascular endothelial growth factor is a secreted angiogenic mitogen

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The p160 RhoA-binding kinase ROK alpha is a member of a kinase family and is involved in the reorganization of the cytoskeleton

1 reference

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7 January 2021

c-Myc represses transcription in vivo by a novel mechanism dependent on the initiator element and Myc box II

1 reference

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Methylation and silencing of the Thrombospondin-1 promoter in human cancer

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Amplification and expression of the c-myc oncogene in human lung cancer cell lines

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A modified oestrogen receptor ligand-binding domain as an improved switch for the regulation of heterologous proteins

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Hierarchical phosphorylation at N-terminal transformation-sensitive sites in c-Myc protein is regulated by mitogens and in mitosis

1 reference

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Contributions of tumor and stromal matrix metalloproteinases to tumor progression, invasion and metastasis

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7 January 2021

Dominant negative mutants of Myc inhibit cooperation of both Myc and adenovirus serotype-5 E1a with Ras

1 reference

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7 January 2021

Rho-associated kinase, a novel serine/threonine kinase, as a putative target for small GTP binding protein Rho

1 reference

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Elevated levels of an angiogenic peptide, basic fibroblast growth factor, in the urine of patients with a wide spectrum of cancers

1 reference

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Regulation of c-Myc through phosphorylation at Ser-62 and Ser-71 by c-Jun N-terminal kinase

1 reference

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An Essential Role for Rho, Rac, and Cdc42 GTPases in Cell Cycle Progression Through G 1

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Angiostatin induces and sustains dormancy of human primary tumors in mice

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Endostatin: an endogenous inhibitor of angiogenesis and tumor growth

1 reference

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Suppression of Myc-induced apoptosis in beta cells exposes multiple oncogenic properties of Myc and triggers carcinogenic progression.

1 reference

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Regulation of G1 progression by the PTEN tumor suppressor protein is linked to inhibition of the phosphatidylinositol 3-kinase/Akt pathway

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Determination of GTP loading on Rho

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Human neuroblastoma cells produce extracellular matrix-degrading enzymes, induce endothelial cell proliferation and are angiogenicin vivo

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The GTP-binding protein Rho

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Thrombospondin-1 suppresses spontaneous tumor growth and inhibits activation of matrix metalloproteinase-9 and mobilization of vascular endothelial growth factor

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ROCK and Dia have opposing effects on adherens junctions downstream of Rho

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Transformation mediated by RhoA requires activity of ROCK kinases

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Multiple Ras-dependent phosphorylation pathways regulate Myc protein stability.

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The significance of oncogene amplification in primary breast cancer

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Coordinated increase in activities of the signal transduction enzymes PI kinase and PIP kinase in human cancer cells

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Angiogenin supports endothelial and fibroblast cell adhesion

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Repression of p15INK4b expression by Myc through association with Miz-1

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Viral Myc oncoproteins in infected fibroblasts down-modulate thrombospondin-1, a possible tumor suppressor gene

1 reference

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Evidence for rearrangement, amplification, and expression of c-myc in a human glioblastoma

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Calcium sensitization of smooth muscle mediated by a Rho-associated protein kinase in hypertension

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Id1 regulates angiogenesis through transcriptional repression of thrombospondin-1

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PTEN controls tumor-induced angiogenesis

1 reference

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7 January 2021

Multiple Ras functions can contribute to mammalian cell transformation

1 reference

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Amplification, Expression and Rearrangement of c-myc and N-myc Oncogenes in Human Lung Cancer

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Measurement of oxygen diffusion distance in tumor cubes using a fluorescent hypoxia probe

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Identifiers

DOI

10.1016/S1535-6108(03)00030-8

1 reference

22 September 2017

1 reference