Akt1 regulates pathological angiogenesis, vascular maturation and permeability in vivo (Q24648140)

2

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Olga Razorenova

3

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William S Chen

4

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Nissim Hay

5

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Paul Bornstein

6

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Tatiana V Byzova

Thrombospondin 2 inhibits microvascular endothelial cell proliferation by a caspase-independent mechanism

7

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language of work or name

English

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publication date

November 2005

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published in

Nature Medicine

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volume

11

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page(s)

1188-96

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issue

11

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cites work

1 reference

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Growth retardation and increased apoptosis in mice with homozygous disruption of the Akt1 gene

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Leakage-resistant blood vessels in mice transgenically overexpressing angiopoietin-1

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Mechanisms of angiogenesis

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Angiogenesis in cancer, vascular, rheumatoid and other disease

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Angiogenesis in health and disease

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Matrix metalloproteinases and tissue inhibitors of metalloproteinases: structure, function, and biochemistry

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Akt1 in the cardiovascular system: friend or foe?

7 April 2017

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Endothelial nitric oxide synthase is critical for ischemic remodeling, mural cell recruitment, and blood flow reserve

28 September 2017

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PI3K rescues the detrimental effects of chronic Akt activation in the heart during ischemia/reperfusion injury

28 September 2017

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VEGF-integrin interplay controls tumor growth and vascularization.

28 September 2017

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Thrombospondin-1 up-regulates expression of cell adhesion molecules and promotes monocyte binding to endothelium

28 September 2017

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The tumor suppressor PTEN inhibits EGF-induced TSP-1 and TIMP-1 expression in FTC-133 thyroid carcinoma cells.

28 September 2017

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The biology of vascular endothelial growth factors.

28 September 2017

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Microvascular patterning is controlled by fine-tuning the Akt signal

28 September 2017

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p21-activated kinase regulates endothelial permeability through modulation of contractility.

28 September 2017

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Akt and hypoxia-inducible factor-1 independently enhance tumor growth and angiogenesis.

28 September 2017

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Enhanced growth of pancreatic tumors in SPARC-null mice is associated with decreased deposition of extracellular matrix and reduced tumor cell apoptosis

28 September 2017

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Impaired platelet responses to thrombin and collagen in AKT-1-deficient mice

28 September 2017

1 reference

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The role of thrombospondins 1 and 2 in the regulation of cell-matrix interactions, collagen fibril formation, and the response to injury

28 September 2017

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Molecular pathway for cancer metastasis to bone

28 September 2017

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Dwarfism, impaired skin development, skeletal muscle atrophy, delayed bone development, and impeded adipogenesis in mice lacking Akt1 and Akt2.

28 September 2017

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The lack of thrombospondin-1 (TSP1) dictates the course of wound healing in double-TSP1/TSP2-null mice

28 September 2017

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Role of Akt signaling in vascular homeostasis and angiogenesis

28 September 2017

1 reference

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Increased vascular permeability in C1 inhibitor-deficient mice mediated by the bradykinin type 2 receptor

28 September 2017

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Thrombospondin-1 suppresses spontaneous tumor growth and inhibits activation of matrix metalloproteinase-9 and mobilization of vascular endothelial growth factor

28 September 2017

1 reference

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Role of fibrin matrix in angiogenesis.

28 September 2017

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Thrombospondins as matricellular modulators of cell function

28 September 2017

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Phosphatidylinositol 3-kinase signaling mediates angiogenesis and expression of vascular endothelial growth factor in endothelial cells

28 September 2017

1 reference

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Activation of integrin alpha(V)beta(3) regulates cell adhesion and migration to bone sialoprotein

28 September 2017

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The regulation and activities of the multifunctional serine/threonine kinase Akt/PKB.

28 September 2017

1 reference

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Integrins and vascular extracellular matrix assembly

28 September 2017

1 reference

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Akt1/protein kinase Balpha is critical for ischemic and VEGF-mediated angiogenesis

28 September 2017

1 reference

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Disruption of coordinated cardiac hypertrophy and angiogenesis contributes to the transition to heart failure

30 May 2018

1 reference

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Membrane type I matrix metalloproteinase usurps tumor growth control imposed by the three-dimensional extracellular matrix.

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2277080

Adenovirus encoding vascular endothelial growth factor-D induces tissue-specific vascular patterns in vivo.

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2277080

Increased and prolonged inflammation and angiogenesis in delayed-type hypersensitivity reactions elicited in the skin of thrombospondin-2--deficient mice

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2277080

Synergism between vascular endothelial growth factor and placental growth factor contributes to angiogenesis and plasma extravasation in pathological conditions.

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2277080

Induction of vascular endothelial growth factor by hypoxia is modulated by a phosphatidylinositol 3-kinase/Akt signaling pathway in Ha-ras-transformed cells through a hypoxia inducible factor-1 transcriptional element

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2277080

A mechanism for modulation of cellular responses to VEGF: activation of the integrins

28 November 2018

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12 December 2020

Enhanced pathological angiogenesis in mice lacking β3 integrin or β3 and β5 integrins

1 reference

12 December 2020

Essential role of endothelial nitric oxide synthase for mobilization of stem and progenitor cells

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12 December 2020

A general strategy for isolation of endothelial cells from murine tissues. Characterization of two endothelial cell lines from the murine lung and subcutaneous sponge implants

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12 December 2020

Ischemia- and cytokine-induced mobilization of bone marrow-derived endothelial progenitor cells for neovascularization

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12 December 2020

Identifiers

DOI

10.1038/NM1307

1 reference

Dimensions Publication ID

702558

1005195476

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702558

1 reference

1 reference

1 reference