PYK2 sustains endosomal-derived receptor signalling and enhances epithelial-to-mesenchymal transition. (Q38913313)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25648557%20AND%20SRC:MED&resulttype=core&format=json

29 February 2020

title

PYK2 sustains endosomal-derived receptor signalling and enhances epithelial-to-mesenchymal transition (English)

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25648557%20AND%20SRC:MED&resulttype=core&format=json

29 February 2020

4

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25648557%20AND%20SRC:MED&resulttype=core&format=json

29 February 2020

Sima Lev

6

0 references

Martin Filipits

object named as

Martin Filipits

5

0 references

author name string

Nandini Verma

1

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25648557%20AND%20SRC:MED&resulttype=core&format=json

29 February 2020

Omer Keinan

2

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25648557%20AND%20SRC:MED&resulttype=core&format=json

29 February 2020

Michael Selitrennik

3

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25648557%20AND%20SRC:MED&resulttype=core&format=json

29 February 2020

language of work or name

English

0 references

publication date

4 February 2015

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25648557%20AND%20SRC:MED&resulttype=core&format=json

29 February 2020

published in

Nature Communications

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25648557%20AND%20SRC:MED&resulttype=core&format=json

29 February 2020

volume

6

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25648557%20AND%20SRC:MED&resulttype=core&format=json

29 February 2020

page(s)

6064

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25648557%20AND%20SRC:MED&resulttype=core&format=json

https://scigraph.springernature.com/pub.10.1038/ncomms7064

29 February 2020

exact match

0 references

cites work

Signaling specificity: the RTK/RAS/MAP kinase pathway in metazoans

1 reference

https://api.crossref.org/works/10.1038%2FNCOMMS7064

Specificity of receptor tyrosine kinase signaling: transient versus sustained extracellular signal-regulated kinase activation

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCOMMS7064

Quantitative analysis of transient and sustained transforming growth factor-β signaling dynamics.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCOMMS7064

Endocytosis and signalling: intertwining molecular networks

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCOMMS7064

Transforming growth factor beta depletion is the primary determinant of Smad signaling kinetics

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCOMMS7064

Robust, tunable biological oscillations from interlinked positive and negative feedback loops.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCOMMS7064

TMEPAI, a transmembrane TGF-beta-inducible protein, sequesters Smad proteins from active participation in TGF-beta signaling

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCOMMS7064

The IkappaB-NF-kappaB signaling module: temporal control and selective gene activation

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCOMMS7064

Activation of an inducible c-FosER fusion protein causes loss of epithelial polarity and triggers epithelial-fibroblastoid cell conversion

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCOMMS7064

Epithelial-mesenchymal transition in cancer development and its clinical significance

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCOMMS7064

The basics of epithelial-mesenchymal transition

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCOMMS7064

Epithelial-mesenchymal transition and cancer stem cells: a dangerously dynamic duo in breast cancer progression

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCOMMS7064

The Snail genes as inducers of cell movement and survival: implications in development and cancer.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCOMMS7064

Epithelial-mesenchymal transition: at the crossroads of development and tumor metastasis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCOMMS7064

Sustained TGF beta exposure suppresses Smad and non-Smad signalling in mammary epithelial cells, leading to EMT and inhibition of growth arrest and apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCOMMS7064

Temporal and spatial cooperation of Snail1 and Twist1 during epithelial-mesenchymal transition predicts for human breast cancer recurrence

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCOMMS7064

Cellular functions of FAK kinases: insight into molecular mechanisms and novel functions

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCOMMS7064

Focal adhesion kinase-related proline-rich tyrosine kinase 2 and focal adhesion kinase are co-overexpressed in early-stage and invasive ErbB-2-positive breast cancer and cooperate for breast cancer cell tumorigenesis and invasiveness

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCOMMS7064

Proline-rich tyrosine kinase 2 (Pyk2) promotes proliferation and invasiveness of hepatocellular carcinoma cells through c-Src/ERK activation

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCOMMS7064

Proline-rich tyrosine kinase 2 (Pyk2) promotes cell motility of hepatocellular carcinoma through induction of epithelial to mesenchymal transition

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCOMMS7064

Protein tyrosine kinase PYK2 involved in Ca(2+)-induced regulation of ion channel and MAP kinase functions

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCOMMS7064

Targeting of PYK2 to focal adhesions as a cellular mechanism for convergence between integrins and G protein-coupled receptor signaling cascades

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCOMMS7064

Targeting Pyk2 for therapeutic intervention

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCOMMS7064

Up-regulation of proline-rich tyrosine kinase 2 in non-small cell lung cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCOMMS7064

TGF-β stimulates Pyk2 expression as part of an epithelial-mesenchymal transition program required for metastatic outgrowth of breast cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCOMMS7064

Hic-5 promotes invadopodia formation and invasion during TGF-β-induced epithelial-mesenchymal transition.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCOMMS7064

Non-stimulated, agonist-stimulated and store-operated Ca2+ influx in MDA-MB-468 breast cancer cells and the effect of EGF-induced EMT on calcium entry

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCOMMS7064

Identification of human triple-negative breast cancer subtypes and preclinical models for selection of targeted therapies

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCOMMS7064

Lysosomal targeting of E-cadherin: a unique mechanism for the down-regulation of cell-cell adhesion during epithelial to mesenchymal transitions

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCOMMS7064

Regulation of E-cadherin/Catenin association by tyrosine phosphorylation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCOMMS7064

Disassembling adherens junctions: breaking up is hard to do.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCOMMS7064

Epithelial-mesenchymal transition and its implications for fibrosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCOMMS7064

New insights into the regulation of epithelial-mesenchymal transition and tissue fibrosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCOMMS7064

Snail, Zeb and bHLH factors in tumour progression: an alliance against the epithelial phenotype?

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCOMMS7064

Twist is a transcriptional repressor of E-cadherin gene expression in breast cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCOMMS7064

Molecular mechanisms of epithelial-mesenchymal transition

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCOMMS7064

Increased expression of Slug and Vimentin as novel predictive biomarkers for lymph node metastasis and poor prognosis in colorectal cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCOMMS7064

Correlation of Snail expression with histological grade and lymph node status in breast carcinomas

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCOMMS7064

HGF-independent potentiation of EGFR action by c-Met

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCOMMS7064

Targeting MET in cancer: rationale and progress

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCOMMS7064

ErbB/EGF signaling and EMT in mammary development and breast cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCOMMS7064

Stattic: a small-molecule inhibitor of STAT3 activation and dimerization

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCOMMS7064

Surgery-induced wound response promotes stem-like and tumor-initiating features of breast cancer cells, via STAT3 signaling

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCOMMS7064

Spacing of palindromic half sites as a determinant of selective STAT (signal transducers and activators of transcription) DNA binding and transcriptional activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCOMMS7064

STAT3 inhibition in prostate and pancreatic cancer lines by STAT3 binding sequence oligonucleotides: differential activity between 5' and 3' ends

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCOMMS7064

Nuclear interaction of EGFR and STAT3 in the activation of the iNOS/NO pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCOMMS7064

Met induces mammary tumors with diverse histologies and is associated with poor outcome and human basal breast cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCOMMS7064

High MET expression is an adverse prognostic factor in patients with triple-negative breast cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCOMMS7064

The Met oncogene and basal-like breast cancer: another culprit to watch out for?

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCOMMS7064

Activation of the c-Met receptor complex in fibroblasts drives invasive cell behavior by signaling through transcription factor STAT3.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCOMMS7064

Requirement of Stat3 signaling for HGF/SF-Met mediated tumorigenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCOMMS7064

Lymphatic vessels in cancer metastasis: bridging the gaps

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCOMMS7064

Src-dependent tyrosine phosphorylation regulates dynamin self-assembly and ligand-induced endocytosis of the epidermal growth factor receptor

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCOMMS7064

Cross-talk between epidermal growth factor receptor and c-Met signal pathways in transformed cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCOMMS7064

Src promotes destruction of c-Cbl: implications for oncogenic synergy between Src and growth factor receptors

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCOMMS7064

Epidermal growth factor receptor cooperates with signal transducer and activator of transcription 3 to induce epithelial-mesenchymal transition in cancer cells via up-regulation of TWIST gene expression

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCOMMS7064

An overview of the c-MET signaling pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCOMMS7064

MET is a potential target for use in combination therapy with EGFR inhibition in triple-negative/basal-like breast cancer.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCOMMS7064

The phosphatidylinositol-transfer protein Nir2 binds phosphatidic acid and positively regulates phosphoinositide signalling

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCOMMS7064

Subcellular distribution of p210(BCR-ABL) in CML cell lines and primary CD34+ CML cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCOMMS7064

The tyrosine kinase pyk2 promotes migration and invasion of glioma cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCOMMS7064

Structural requirements for VAP-B oligomerization and their implication in amyotrophic lateral sclerosis-associated VAP-B(P56S) neurotoxicity.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCOMMS7064

The lipid-transfer protein Nir2 enhances epithelial-mesenchymal transition and facilitates breast cancer metastasis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCOMMS7064

Chemical genetic analysis of the time course of signal transduction by JNK

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCOMMS7064

7 January 2021

Endocytosis of receptor tyrosine kinases

1 reference

https://api.crossref.org/works/10.1038%2FNCOMMS7064

7 January 2021

Crosstalk and signaling switches in mitogen-activated protein kinase cascades

1 reference

https://api.crossref.org/works/10.1038%2FNCOMMS7064

7 January 2021

ICAM-1-mediated, Src- and Pyk2-dependent vascular endothelial cadherin tyrosine phosphorylation is required for leukocyte transendothelial migration

1 reference

https://api.crossref.org/works/10.1038%2FNCOMMS7064

7 January 2021

Identifiers

DOI

10.1038/NCOMMS7064

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25648557%20AND%20SRC:MED&resulttype=core&format=json

Dimensions Publication ID

29 February 2020

ADS bibcode

2015NatCo...6.6064V

0 references

0 references

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25648557%20AND%20SRC:MED&resulttype=core&format=json