The role of enhancers in cancer (Q38882532)

7 September 2017

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title

The role of enhancers in cancer (English)

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7 September 2017

Inderpreet Sur

1

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7 September 2017

Jussi Taipale

series ordinal

2

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7 September 2017

language of work or name

English

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publication date

1 July 2016

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7 September 2017

Nature Reviews Cancer

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7 September 2017

16

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7 September 2017

8

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7 September 2017

483-493

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https://scigraph.springernature.com/pub.10.1038/nrc.2016.62

7 September 2017

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31 March 2020

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31 March 2020

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31 March 2020

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31 March 2020

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31 March 2020

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Epigenomic enhancer profiling defines a signature of colon cancer

31 March 2020

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DNA methylation of distal regulatory sites characterizes dysregulation of cancer genes

31 March 2020

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31 March 2020

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31 March 2020

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31 March 2020

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An 8q24 gene desert variant associated with prostate cancer risk confers differential in vivo activity to a MYC enhancer

31 March 2020

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8q24 prostate, breast, and colon cancer risk loci show tissue-specific long-range interaction with MYC.

31 March 2020

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The common colorectal cancer predisposition SNP rs6983267 at chromosome 8q24 confers potential to enhanced Wnt signaling.

31 March 2020

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The 8q24 cancer risk variant rs6983267 shows long-range interaction with MYC in colorectal cancer

31 March 2020

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https://api.crossref.org/works/10.1038%2FNRC.2016.62

The NHGRI GWAS Catalog, a curated resource of SNP-trait associations

31 March 2020

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Potential etiologic and functional implications of genome-wide association loci for human diseases and traits

31 March 2020

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https://api.crossref.org/works/10.1038%2FNRC.2016.62

Genomewide association studies and assessment of the risk of disease

31 March 2020

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https://api.crossref.org/works/10.1038%2FNRC.2016.62

Linking disease associations with regulatory information in the human genome

31 March 2020

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https://api.crossref.org/works/10.1038%2FNRC.2016.62

Systematic localization of common disease-associated variation in regulatory DNA

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2016.62

Trait-associated SNPs are more likely to be eQTLs: annotation to enhance discovery from GWAS

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2016.62

Enrichment of inflammatory bowel disease and colorectal cancer risk variants in colon expression quantitative trait loci

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2016.62

Integrative eQTL-based analyses reveal the biology of breast cancer risk loci

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2016.62

Systematic genetic analysis identifies Cis-eQTL target genes associated with glioblastoma patient survival

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2016.62

The role of regulatory variation in complex traits and disease

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2016.62

Multiple functional risk variants in a SMAD7 enhancer implicate a colorectal cancer risk haplotype

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2016.62

Genetic predisposition to neuroblastoma mediated by a LMO1 super-enhancer polymorphism.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2016.62

A prostate cancer susceptibility allele at 6q22 increases RFX6 expression by modulating HOXB13 chromatin binding.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2016.62

Multiple functional variants in long-range enhancer elements contribute to the risk of SNP rs965513 in thyroid cancer

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2016.62

Breast cancer risk variants at 6q25 display different phenotype associations and regulate ESR1, RMND1 and CCDC170.

31 March 2020

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https://api.crossref.org/works/10.1038%2FNRC.2016.62

A common variant associated with prostate cancer in European and African populations

31 March 2020

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https://api.crossref.org/works/10.1038%2FNRC.2016.62

Genome-wide association study identifies a second prostate cancer susceptibility variant at 8q24.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2016.62

Genome-wide association study of prostate cancer identifies a second risk locus at 8q24

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2016.62

Identification of a new prostate cancer susceptibility locus on chromosome 8q24.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2016.62

Multiple loci with different cancer specificities within the 8q24 gene desert

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2016.62

Common variants at 2q37.3, 8q24.21, 15q21.3 and 16q24.1 influence chronic lymphocytic leukemia risk

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2016.62

A genome-wide association scan of tag SNPs identifies a susceptibility variant for colorectal cancer at 8q24.21

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2016.62

Genome-wide association scan identifies a colorectal cancer susceptibility locus on chromosome 8q24.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2016.62

Genome-wide association studies in common cancers--what have we learnt?

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2016.62

The genetics of cancer risk

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2016.62

Lessons from functional analysis of genome-wide association studies

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2016.62

The landscape of somatic copy-number alteration across human cancers

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2016.62

Amplification of distant estrogen response elements deregulates target genes associated with tamoxifen resistance in breast cancer

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2016.62

Allelic Imbalance at rs6983267 Suggests Selection of the Risk Allele in Somatic Colorectal Tumor Evolution

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2016.62

Mice lacking a Myc enhancer that includes human SNP rs6983267 are resistant to intestinal tumors.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2016.62

Identification of focally amplified lineage-specific super-enhancers in human epithelial cancers

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2016.62

A NOTCH1-driven MYC enhancer promotes T cell development, transformation and acute lymphoblastic leukemia

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2016.62

Molecular cytogenetic study of 126 unselected T-ALL cases reveals high incidence of TCRbeta locus rearrangements and putative new T-cell oncogenes

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2016.62

Enhancer hijacking activates GFI1 family oncogenes in medulloblastoma

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2016.62

Activation of proto-oncogenes by disruption of chromosome neighborhoods.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2016.62

Signatures of mutational processes in human cancer

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2016.62

CTCF/cohesin-binding sites are frequently mutated in cancer

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2016.62

Mutational heterogeneity in cancer and the search for new cancer-associated genes

31 March 2020

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https://api.crossref.org/works/10.1038%2FNRC.2016.62

Non-coding recurrent mutations in chronic lymphocytic leukaemia

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2016.62

Chromatin organization is a major influence on regional mutation rates in human cancer cells.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2016.62

Reduced local mutation density in regulatory DNA of cancer genomes is linked to DNA repair

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2016.62

Cell-of-origin chromatin organization shapes the mutational landscape of cancer

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2016.62

TERT promoter mutations in familial and sporadic melanoma

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2016.62

Highly recurrent TERT promoter mutations in human melanoma

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2016.62

Recurrent somatic mutations in regulatory regions of human cancer genomes

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2016.62

Genome-wide analysis of noncoding regulatory mutations in cancer

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2016.62

TERT promoter mutations occur early in urothelial neoplasia and are biomarkers of early disease and disease recurrence in urine

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2016.62

High frequency of telomerase reverse-transcriptase promoter somatic mutations in hepatocellular carcinoma and preneoplastic lesions

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2016.62

The emerging complexity of gene fusions in cancer

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2016.62

The impact of translocations and gene fusions on cancer causation

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2016.62

The androgen receptor cistrome is extensively reprogrammed in human prostate tumorigenesis

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2016.62

Cohesin gene mutations in tumorigenesis: from discovery to clinical significance

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2016.62

Mutations in regulators of the epigenome and their connections to global chromatin patterns in cancer

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2016.62

Regulation of chromatin by histone modifications

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2016.62

Mediator and cohesin connect gene expression and chromatin architecture

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2016.62

Hdac3 is essential for the maintenance of chromatin structure and genome stability

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2016.62

Rad21-cohesin haploinsufficiency impedes DNA repair and enhances gastrointestinal radiosensitivity in mice

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2016.62

DNMT3A in haematological malignancies

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2016.62

Connections between TET proteins and aberrant DNA modification in cancer

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2016.62

Pan-cancer patterns of DNA methylation.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2016.62

IDH mutation impairs histone demethylation and results in a block to cell differentiation

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2016.62

IDH1 mutation is sufficient to establish the glioma hypermethylator phenotype

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2016.62

Leukemic IDH1 and IDH2 mutations result in a hypermethylation phenotype, disrupt TET2 function, and impair hematopoietic differentiation

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2016.62

Silencing of the VHL tumor-suppressor gene by DNA methylation in renal carcinoma

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2016.62

Promoter hypermethylation and BRCA1 inactivation in sporadic breast and ovarian tumors

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2016.62

Cross-talk between site-specific transcription factors and DNA methylation states

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2016.62

Insulator dysfunction and oncogene activation in IDH mutant gliomas

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2016.62

CpG island methylator phenotype in colorectal cancer

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2016.62

Enhancer-targeted genome editing selectively blocks innate resistance to oncokinase inhibition

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2016.62

Effects on the transcriptome upon deletion of a distal element cannot be predicted by the size of the H3K27Ac peak in human cells

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2016.62

Activity of a heptad of transcription factors is associated with stem cell programs and clinical outcome in acute myeloid leukemia

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2016.62

Identification of tissue-specific cell death using methylation patterns of circulating DNA

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2016.62

Plasma DNA tissue mapping by genome-wide methylation sequencing for noninvasive prenatal, cancer, and transplantation assessments

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2016.62

Cell-free DNA Comprises an In Vivo Nucleosome Footprint that Informs Its Tissues-Of-Origin

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2016.62

CDK7 inhibition suppresses super-enhancer-linked oncogenic transcription in MYCN-driven cancer.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2016.62

BET bromodomain inhibition as a therapeutic strategy to target c-Myc

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2016.62

Selective inhibition of BET bromodomains

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2016.62

New and emerging HDAC inhibitors for cancer treatment

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2016.62

Histone deacetylase inhibitor selectively induces p21WAF1 expression and gene-associated histone acetylation

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2016.62

Inhibitors of histone deacetylases induce tumor-selective apoptosis through activation of the death receptor pathway

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2016.62

Positive regulation of c-Myc by cohesin is direct, and evolutionarily conserved

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2016.62

Cohesin is required for activation of MYC by estradiol

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2016.62

Mediator kinase inhibition further activates super-enhancer-associated genes in AML

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2016.62

Tumor-selective action of HDAC inhibitors involves TRAIL induction in acute myeloid leukemia cells

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2016.62

Induction of polyploidy by histone deacetylase inhibitor: a pathway for antitumor effects

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2016.62

Histone deacetylase (HDAC) inhibitor activation of p21WAF1 involves changes in promoter-associated proteins, including HDAC1

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2016.62

Transcriptional plasticity promotes primary and acquired resistance to BET inhibition

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2016.62

GLI2-dependent c-MYC upregulation mediates resistance of pancreatic cancer cells to the BET bromodomain inhibitor JQ1.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2016.62

BET inhibitor resistance emerges from leukaemia stem cells

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2016.62

Cancer drug resistance: an evolving paradigm

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2016.62

Molecularly targeted cancer therapy: some lessons from the past decade

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2016.62

MYC: connecting selective transcriptional control to global RNA production.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2016.62

Inducible in vivo silencing of Brd4 identifies potential toxicities of sustained BET protein inhibition

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2016.62

A long-range Shh enhancer regulates expression in the developing limb and fin and is associated with preaxial polydactyly

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2016.62

An integrated encyclopedia of DNA elements in the human genome

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2016.62

Distinct and predictive chromatin signatures of transcriptional promoters and enhancers in the human genome

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2016.62

CTCF: an architectural protein bridging genome topology and function

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2016.62

Topological domains in mammalian genomes identified by analysis of chromatin interactions

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2016.62

Autoregulatory and gap gene response elements of the even-skipped promoter of Drosophila

31 March 2020

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/27364481

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1038/NRC.2016.62

1 reference

Dimensions Publication ID

7 September 2017

0 references

1 reference