HER2-mTOR signaling-driven breast cancer cells require ER-associated degradation to survive (Q38870753)

7 September 2017

HER2-mTOR signaling-driven breast cancer cells require ER-associated degradation to survive (English)

1 reference

7 September 2017

Navneet Singh

1

1 reference

PubMed ID

26012635

7 September 2017

Rashika Joshi

series ordinal

2

1 reference

PubMed ID

26012635

7 September 2017

Kakajan Komurov

series ordinal

3

1 reference

7 September 2017

26 May 2015

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7 September 2017

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7 September 2017

8

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7 September 2017

378

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7 September 2017

ra52

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Principles of cancer therapy: oncogene and non-oncogene addiction

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Non-oncogene addiction and the stress phenotype of cancer cells

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Exploiting cancer cell vulnerabilities to develop a combination therapy for ras-driven tumors.

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The GATA2 transcriptional network is requisite for RAS oncogene-driven non-small cell lung cancer

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β-Catenin-driven cancers require a YAP1 transcriptional complex for survival and tumorigenesis

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The Cancer Cell Line Encyclopedia enables predictive modelling of anticancer drug sensitivity

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Systematic identification of genomic markers of drug sensitivity in cancer cells

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Systematic investigation of genetic vulnerabilities across cancer cell lines reveals lineage-specific dependencies in ovarian cancer

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Inconsistency in large pharmacogenomic studies

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International network of cancer genome projects

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Hallmarks of Cancer: The Next Generation

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A comparative survey of functional footprints of EGFR pathway mutations in human cancers.

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Comprehensive molecular portraits of human breast tumours

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The genomic and transcriptomic architecture of 2,000 breast tumours reveals novel subgroups

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DNA damage response as a candidate anti-cancer barrier in early human tumorigenesis

21 January 2018

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Oncogene-induced senescence is part of the tumorigenesis barrier imposed by DNA damage checkpoints

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Oncogene-induced senescence as an initial barrier in lymphoma development

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Oncogenic ras provokes premature cell senescence associated with accumulation of p53 and p16INK4a

21 January 2018

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Dose-dependent oncogene-induced senescence in vivo and its evasion during mammary tumorigenesis.

21 January 2018

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Co-expression of HER2 and HER3 receptor tyrosine kinases enhances invasion of breast cells via stimulation of interleukin-8 autocrine secretion

21 January 2018

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NetWalker: a contextual network analysis tool for functional genomics

21 January 2018

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Use of data-biased random walks on graphs for the retrieval of context-specific networks from genomic data

21 January 2018

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The unfolded protein response: controlling cell fate decisions under ER stress and beyond

21 January 2018

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Cleaning up: ER-associated degradation to the rescue

21 January 2018

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Defining human ERAD networks through an integrative mapping strategy

21 January 2018

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Covalent and allosteric inhibitors of the ATPase VCP/p97 induce cancer cell death

21 January 2018

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Reversible inhibitor of p97, DBeQ, impairs both ubiquitin-dependent and autophagic protein clearance pathways

21 January 2018

1 reference

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Inhibition of p97-dependent protein degradation by Eeyarestatin I

21 January 2018

1 reference

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Quantitative cell-based protein degradation assays to identify and classify drugs that target the ubiquitin-proteasome system

21 January 2018

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The ERAD inhibitor Eeyarestatin I is a bifunctional compound with a membrane-binding domain and a p97/VCP inhibitory group

21 January 2018

1 reference

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HMG-CoA reductase inhibitors activate the unfolded protein response and induce cytoprotective GRP78 expression.

21 January 2018

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The CrebA/Creb3-like transcription factors are major and direct regulators of secretory capacity

21 January 2018

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Luman/CREB3 induces transcription of the endoplasmic reticulum (ER) stress response protein Herp through an ER stress response element

21 January 2018

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Dysregulated mTORC1 renders cells critically dependent on desaturated lipids for survival under tumor-like stress

21 January 2018

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Inhibition of mammalian target of rapamycin is required for optimal antitumor effect of HER2 inhibitors against HER2-overexpressing cancer cells

21 January 2018

1 reference

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Evaluation of statistical methods for normalization and differential expression in mRNA-Seq experiments

21 January 2018

1 reference

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ER stress-induced cell death mechanisms

21 January 2018

1 reference

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Mitogen-activated protein kinase (MAPK) phosphatase-3 (MKP-3) displays a p-JNK-MAPK substrate preference in astrocytes in vitro.

21 January 2018

1 reference

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The dual-specificity MAP kinase phosphatases: critical roles in development and cancer

21 January 2018

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Zebrafish chemical screening reveals an inhibitor of Dusp6 that expands cardiac cell lineages

21 January 2018

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Epidermal growth factor receptor targeting in cancer: a review of trends and strategies.

21 January 2018

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Predicting cancer-specific vulnerability via data-driven detection of synthetic lethality

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Passenger deletions generate therapeutic vulnerabilities in cancer

21 January 2018

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Cancer vulnerabilities unveiled by genomic loss

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RalB GTPase-mediated activation of the IkappaB family kinase TBK1 couples innate immune signaling to tumor cell survival

21 January 2018

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TAK1 inhibition promotes apoptosis in KRAS-dependent colon cancers.

21 January 2018

1 reference

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Anti-oncogenic role of the endoplasmic reticulum differentially activated by mutations in the MAPK pathway.

21 January 2018

1 reference

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The critical roles of endoplasmic reticulum chaperones and unfolded protein response in tumorigenesis and anticancer therapies

21 January 2018

1 reference

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The role of the unfolded protein response in tumour development: friend or foe?

21 January 2018

1 reference

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Targeting the unfolded protein response in disease.

21 January 2018

1 reference

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Control of tumor bioenergetics and survival stress signaling by mitochondrial HSP90s

21 January 2018

1 reference

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ER stress-mediated autophagy promotes Myc-dependent transformation and tumor growth

21 January 2018

1 reference

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The glucose-deprivation network counteracts lapatinib-induced toxicity in resistant ErbB2-positive breast cancer cells

21 January 2018

1 reference

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10.1126/SCISIGNAL.AAA6922

21 January 2018

Identifiers

DOI

1 reference

7 September 2017

1 reference

PubMed ID

26012635